How useful is the EQ-5D in assessing the impact of caring for people with Alzheimer’s disease?

Table 2 Caregiver HRQoL (EQ-5D) and burden scores at baseline

Measure	n	Mean (SD)	Median (Q1, Q3)	P value^a
EQ-5D index score^b	1483	0.84 (0.20)	0.89 (0.79, 1.00)
Mild AD dementia	560	0.86 (0.18)	0.89 (0.79, 1.00)	0.043
Moderate AD dementia	469	0.85 (0.19)	0.89 (0.79, 1.00)
MS/S AD dementia	454	0.82 (0.23)	0.89 (0.73, 1.00)
EQ-5D VAS score^c	1483	75.1 (17.5)	80.0 (65.0, 90.0)
Mild AD dementia	560	75.8 (16.6)	80.0 (69.0, 89.0)	0.013
Moderate AD dementia	469	76.3 (16.5)	80.0 (69.0, 90.0)
MS/S AD dementia	454	72.9 (19.2)	79.0 (60.0, 89.0)
ZBI total score^d	1485	29.0 (15.1)	28.0 (17.0, 40.0)
Mild AD dementia	560	24.6 (14.2)	22.0 (14.0, 33.0)	<0.001
Moderate AD dementia	471	29.4 (14.8)	29.0 (18.0, 39.0)
MS/S AD dementia	454	34.1 (14.8)	33.0 (22.0, 45.0)
T-IADL (hours/month)	1493	79.3 (89.5)	60.0 (20.0, 120.0)
Mild AD dementia	565	61.0 (83.1)	36.0 (8.0, 90.0)	<0.001
Moderate AD dementia	472	77.5 (79.2)	60.0 (24.0, 120.0)
MS/S AD dementia	456	103.8 (101.1)	90.0 (40.0, 120.8)

AD Alzheimer’s disease; EQ-5D EuroQol-5 dimension questionnaire; HRQoL health-related quality of life; MS/S moderately severe/severe; Q1, Q3 interquartile range; SD standard deviation; T-IADL time spent on instrumental activities of daily living; VAS visual analog scale; ZBI Zarit Burden Interview
Missing data (overall): EQ-5D, n = 12; ZBI, n = 10; T-IADL, n = 2
^aComparisons between AD severity groups used analysis of variance (ANOVA) with country and baseline Mini-Mental State Examination (MMSE) severity as independent factors
^bCountry-specific health status index score; range 0 to 1.0, higher scores indicate better health-related quality of life
^cEQ-5D VAS score range = 0–100, higher scores indicate better health-related quality of life
^dZBI total score range = 0–88, higher scores indicate greater burden

ISSN: 1477-7525