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Table 2 Baseline disease parameters overall and by Work Time Loss Category

From: Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies

Variable Work Time Loss Category Overallb p-value
Work Time Lossa No Work Time Loss
Total n, % 247 (57.7) 147 (34.3) 428 -
Time from HZ onset, days
n 247 147 427  
 Mean (SD) 124.2 (458.3) 79.6 (284.2) 128.6 (476.6) <0.001
Time from HZ onset - categorical, n (%)
 Incident 74 (30.0) 65 (44.2) 154 (36.0)  
 Prevalent 173 (70.0) 82 (55.8) 273 (63.8) 0.004
 Not available 0 (0.0) 0 (0.0) 1 (0.2)  
Pain before rash appearance, n (%)
 Yes 156 (63.2) 89 (60.5) 260 (60.7)  
 No 79 (32.0) 52 (35.4) 146 (34.1) 0.520
 Not available 12 (4.9) 6 (4.1) 22 (5.1)  
Average pain score before rash appearancec
n 155 88 258  
 Mean (SD) 4.9 (2.6) 4.4 (2.5) 4.7 (2.6) 0.148
Worst pain before rash appearancec
n 154 86 255  
 Mean (SD) 6.4 (2.6) 5.8 (2.5) 6.2 (2.6) 0.057
Pain since rash appearance, n (%)
 Yes 222 (89.9) 130 (88.4) 376 (87.9)  
 No 14 (5.7) 12 (8.2) 33 (7.7) 0.349
 Not available 11 (4.5) 5 (3.4) 19 (4.4)  
Average pain since rash appearancec
n 222 129 375  
 Mean (SD) 5.6 (2.3) 4.7 (2.2) 5.3 (2.3) 0.002
Worst pain since rash appearancec
n 221 128 373  
 Mean (SD) 7.6 (2.3) 6.5 (2.5) 7.2 (2.5) <0.001
Pain in the last 24 hs
 Yes 224 (90.7) 126 (85.7) 380 (88.8)  
 No 23 (9.3) 20 (13.6) 47 (11.0) 0.178
 Not available 0 (0.0) 1 (0.7) 1 (0.2)  
Average pain in last 24 hc
n 224 126 380  
 Mean (SD) 4.5 (2.5) 4.0 (2.3) 4.3 (2.4) 0.062
Worst pain in last 24 hc
n 220 124 372  
 Mean (SD) 6.2 (2.6) 5.4 (2.6) 5.9 (2.6) 0.004
Worst pain score category, n (%)d
 Mild 43 (17.4) 35 (23.8) 83 (19.4)  
 Moderate 91 (36.8) 55 (37.4) 161 (37.6) 0.041
 Severe 86 (34.8) 33 (22.4) 127 (29.7)  
 Not available 27 (10.9) 24 (16.3) 57 (13.3)  
Severity of rash (number of lesions), n (%)
 No rash 56 (22.7) 18 (12.2) 84 (19.6)  
 Mild (1–20) 107 (43.3) 86 (58.5) 207 (48.4)  
 Moderate (21–50) 49 (19.8) 24 (16.3) 77 (18.0) 0.014
 Severe (>50) 35 (14.2) 18 (12.2) 59 (13.8)  
 Not available 0 (0.0) 1 (0.7) 1 (0.2)  
Impaired immune statuse
 Yes 18 (7.3) 9 (6.1) 29 (6.8)  
 No 229 (92.7) 138 (93.9) 399 (93.2) 0.658
Presence of HZ complication
 Yes 80 (32.4) 40 (27.2) 136 (31.8)  
 No 166 (67.2) 107 (72.8) 291 (68.0) 0.269
 Not available 1 (0.4) 0 (0.0) 1 (0.2)  
Medication for HZ
 Yes 23 (9.3) 24 (16.3) 51 (11.9)  
 No 224 (90.7) 123 (83.7) 377 (88.1) 0.038
  1. SD standard deviation, HZ Herpes Zoster, CIS carcinoma in situ, HIV human immunodeficiency virus, AIDS acquired immune deficiency syndrome
  2. aPatients with Work Time Loss were defined as those who reported missing work due to their shingles episode (entire day or part of a day) at baseline, as assessed by the WPQ
  3. b34 patients did not have information on Work Time Loss Category
  4. cMeasured on an 11 point Likert scale which ranges from “no pain” (0) to “pain as bad as you can imagine” (11)
  5. dWorst pain score categories are based on the ZPBI “worst pain in the last 24 h” scores: mild worst pain = ZBPI scores 0- ≤ 3; moderate worst pain = ZBPI scores 4- ≤ 7; severe worst pain = ZBPI score ≥8
  6. eDefined as: use of high dose oral corticosteroids, invasive cancers (with the exception of CIS and non-melanoma skin cancer), HIV infection/ AIDS, immune deficiency, chemotherapy for cancer, prior or concurrent immunosuppressive therapy, and therapy for organ transplant