Table 4 Observed and adjusted changes of the QLQ–C30 questionnaire after three and six months
QLQ-C30 | After 3Â months | After 6Â months | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Between T0 and T1 | Between T1 and T2 | |||||||||
| Â | Observed changes | Adjusted changes | Â | Observed changes | Adjusted changes | |||||
(post-test - pre-test) | (post-test - then-test) | (post-test - pre-test) | (post-test - then-test) | |||||||
N | Mean (SD) | 95% CI | Mean (SD) | 95% CI | N | Mean (SD) | 95% CI | Mean (SD) | 95% CI | |
GHS | 251 | Â | Â | Â | Â | 251 | Â | Â | Â | Â |
 Little worse | 71 | −16.31 (16.99) | (−20, −13) | −12.44 (16.78) | (−16, −9) | 51 | 0.49 (15.4) | (−3, 4) | −7.84 (15.22) | (−11, −4) |
 No change | 43 | −2.13 (16.17) | (−6, 2) | 4.65 (17.85) | (0, 9) | 50 | −1 (16.12) | (−5, 3) | 7 (14.71) | (4, 10) |
 Little better | 58 | 0.29 (18.4) | (−4, 4) | 1.58 (14.93) | (−2, 5) | 67 | 7.21 (17.22) | (4, 11) | 6.97 (16.70) | (4, 10) |
Physical functioning | 255 | Â | Â | Â | Â | 255 | Â | Â | Â | Â |
 Little worse | 73 | −11.76 (10.99) | (−14, −10) | −12.28 (12.71) | (−15, −10) | 53 | 0.38 (11.43) | (−2, 3) | −9.18 (12.83) | (−12, −6) |
 No change | 46 | −3.99 (10.17) | (−7, −1) | -2.68 (12.76) | (−6, 0) | 51 | 0.72 (6.97) | (−1, 2) | −1.57 (6.34) | (−3, 0) |
 Little better | 57 | −4.53 (12.89) | (−7, −2) | -0.70 (11.86) | (−3, 2) | 69 | 0.85 (13.02) | (−2, 3) | −3.09 (14.03) | (−6, 0) |
Role functioning | 253 | Â | Â | Â | Â | 253 | Â | Â | Â | Â |
 Little worse | 73 | −25.57 (21.71) | (−30, −21) | -18.95 (23.78) | (−24, −14) | 51 | −1.96 (29.18) | (−9, 5) | −17.65 (29.14) | (−24, −11) |
 No change | 46 | −2.90 (19.66) | (−8, 2) | 0.36 (21.80) | (−5, 6) | 51 | 3.92 (15.49) | (0, 8) | 1.96 (19.05) | (−3, 6) |
 Little better | 55 | −9.09 (20.74) | (−14, −4) | 0.91 (24.72) | (−5, 6) | 68 | 5.88 (21.89) | (1, 1) | 0 (23.92) | (−5,5) |
Emotional functioning | 254 | Â | Â | Â | Â | 254 | Â | Â | Â | Â |
 Little worse | 72 | 3.05 (24.09) | (−2, 8) | -6.29 (22.02) | (−11, −2) | 52 | −0.53 (20.19) | (−5, 4) | −6.20 (16.43) | (−10, −2) |
 No change | 44 | 19.44 (18.31) | (15, 24) | 10.92 (18.26) | (6, 16) | 50 | −0.78 (15.55) | (−4, 3) | 8.17 (21.26) | (3, 13) |
 Little better | 59 | 15.07 (26.33) | (9, 21) | 3.95 (19.51) | (0, 8) | 69 | 1.53 (20.05) | (−2, 6) | 7.21 (19.13) | (3, 11) |
Cognitive functioning | 254 | Â | Â | Â | Â | 254 | Â | Â | Â | Â |
 Little worse | 73 | −5.48 (19.46) | (−9, −2) | -10.96 (18.26) | (−15, −7) | 52 | 0.96 (17.9) | (−3, 5) | −9.62 (19.06) | (−14, −5) |
 No change | 44 | 0.76 (13.43) | (−3, 4) | -0.76 (12.43) | (−4, 2) | 50 | 2.67 (12.31) | (0, 6) | 0.33 (15.97) | (−3, 4) |
 Little better | 57 | 5.26 (21.4) | (1, 1) | -0.58 (17.24) | (−4, 3) | 69 | 3.62 (13.37) | (1, 6) | 4.59 (17.82) | (1, 8) |
Social functioning | 249 | Â | Â | Â | Â | 249 | Â | Â | Â | Â |
 Little worse | 72 | −20.37 (21.34) | (−25, −16) | -15.05 (14.84) | (−18, −12) | 52 | 0.64 (24.47) | (−5, 6) | −10.26 (20.39) | (−15, −6) |
 No change | 42 | −3.97 (21.08) | (−9, 2) | -0.79 (17.25) | (−5, 4) | 49 | 4.42 (19.18) | (0, 9) | −0.34 (12.50) | (−3, 3) |
 Little better | 59 | −6.78 (19.6) | (−11, −3) | -3.11 (18.95) | (−7, 1) | 68 | 3.43 (20.68) | (−1, 8) | 2.21 (21.34) | (−2, 7) |
Fatigue | 254 | Â | Â | Â | Â | 254 | Â | Â | Â | Â |
 Little worse | 73 | 27.32 (21.87) | (23, 32) | 22.75 (22.38) | (18, 27) | 53 | 0.21 (16.34) | (−4, 4) | 20.13 (24.17) | (15, 26) |
 No change | 46 | 7.73 (18.42) | (3, 12) | 5.56 (19.42) | (1, 10) | 51 | −1.53 (19.5) | (−6, 3) | 2.18 (19.75) | (−2, 7) |
 Little better | 57 | 7.89 (19.47) | (4, 12) | 3.31 (17.97) | (−1, 7) | 68 | −7.68 (18.24) | (−11, −4) | 2.29 (22.92) | (−2, 7) |
Nausea and vomiting | 255 | Â | Â | Â | Â | 255 | Â | Â | Â | Â |
 Little worse | 74 | 8.78 (19.35) | (5, 13) | 8.33 (15.67) | (5, 11) | 53 | −3.14 (21.7) | (−8, 2) | 0.94 (17.73) | (−3, 5) |
 No change | 46 | −0.72 (12.65) | (−4, 2) | 0 (8.61) | (−2, 2) | 51 | −2.29 (10.01) | (−5, 0) | −1.31 (12.40) | (−4, 2) |
 Little better | 57 | 9.06 (21.38) | (4, 14) | 3.80 (17.82) | (0, 8) | 70 | −6.67 (23.98) | (−11, −2) | 0 (13.31) | (−3, 3) |
Pain | 260 | Â | Â | Â | Â | 260 | Â | Â | Â | Â |
 Little worse | 75 | 13.78 (24.87) | (9, 19) | 9.11 (23.14) | (5, 14) | 54 | 1.85 (22.35) | (−3, 7) | 17.28 (25.89) | (11, 23) |
 No change | 46 | 3.99 (14.57) | (0, 8) | 5.43 (17.23) | (1, 10) | 52 | 3.21 (14.02) | (0, 6) | 5.45 (17.06) | (1, 9) |
 Little better | 57 | 9.94 (20.62) | (5, 15) | 2.63 (21.08) | (−2, 7) | 70 | 2.14 (20.05) | (−2, 6) | 1.90 (22.97) | (−3, 6) |
Dyspnea | 251 | Â | Â | Â | Â | 251 | Â | Â | Â | Â |
 Little worse | 73 | 8.68 (24.86) | (4, 14) | 10.96 (23.61) | (6, 16) | 52 | 3.85 (26.94) | (−2, 10) | 7.69 (18.22) | (3, 12) |
 No change | 45 | 0.74 (19.45) | (−4, 6) | 0.74 (18.10) | (−4, 5) | 51 | −0.65 (12.45) | (−4, 2) | 0 (11.55) | (−3, 3) |
 Little better | 55 | 1.21 (19.21) | (−3, 6) | 1.82 (16.25) | (−2, 5) | 67 | 3.48 (22.57) | (−1, 8) | 7.46 (23.08) | (3, 12) |
Insomnia | 249 | Â | Â | Â | Â | 249 | Â | Â | Â | Â |
 Little worse | 69 | 5.80 (35.22) | (−1, 13) | 8.21 (28.24) | (3, 14) | 52 | 4.49 (30.98) | (−3, 12) | 15.38 (24.22) | (10, 21) |
 No change | 46 | −10.14 (35.04) | (−19, −1) | −2.90 (25.17) | (−9, 3) | 50 | −1.33 (21.25) | (−6, 4) | 2 (28.89) | (−5, 9) |
 Little better | 55 | −7.27 (34.95) | (−15, 1) | 0.61 (25.25) | (−5, 6) | 67 | 1 (30.13) | (−5, 7) | −0.50 (22.09) | (−5, 4) |
Appetite loss | 249 | Â | Â | Â | Â | 249 | Â | Â | Â | Â |
 Little worse | 73 | 10.05 (28.16) | (5, 16) | 10.96 (27.25) | (6, 16) | 53 | −10.06 (25.8) | (−16, −4) | 3.77 (20.32) | (−1, 8) |
 No change | 46 | −2.90 (20.88) | (−8, 2) | 1.45 (17.15) | (−3, 6) | 50 | −2.67 (9.13) | (−5, −1) | −2 (12.44) | (−5, 1) |
 Little better | 54 | 1.85 (22.82) | (−3, 7) | 3.70 (15.41) | (0, 7) | 68 | −2.45 (20.21) | (−7, 2) | −0.49 (14.67) | (−3, 2) |
Constipation | 247 | Â | Â | Â | Â | 247 | Â | Â | Â | Â |
 Little worse | 68 | 15.20 (30.16) | (9, 21) | 10.29 (27.77) | (5, 16) | 48 | −1.39 (24.75) | (−7, 5) | 2.78 (21.56) | (−2, 8) |
 No change | 42 | 0 (19.48) | (−5, 5) | 2.38 (18.61) | (−2, 7) | 48 | −3.47 (12.38) | (−6, 0) | −1.39 (9.62) | (−4, 1) |
 Little better | 58 | 0 (26.49) | (−6, 6) | 0 (16.52) | (−4, 4) | 70 | −2.86 (30.95) | (−9, 3) | 0 (26.62) | (−5, 5) |
Diarrhea | 248 | Â | Â | Â | Â | 248 | Â | Â | Â | Â |
 Little worse | 71 | 0 (21.08) | (−4, 4) | 3.29 (18.07) | (0, 6) | 48 | 0.69 (14.57) | (−3, 4) | 4.17 (13.09) | (1, 7) |
 No change | 43 | −2.33 (15.25) | (−6, 2) | -0.78 (11.47) | (−4, 2) | 48 | −1.39 (9.62) | (−4, 1) | −2.08 (10.67) | (−5, 0) |
 Little better | 56 | −0.6 (21.55) | (−5, 4) | 2.38 (20.94) | (−2, 7) | 69 | −1.93 (17.97) | (−6, 2) | −1.93 (20.52) | (−6, 2) |
Financial difficulties | 240 | Â | Â | Â | Â | 240 | Â | Â | Â | Â |
 Little worse | 69 | 9.66 (22.94) | (5, 14) | 8.21 (22.44) | (4, 13) | 49 | −3.40 (20.69) | (−8, 2) | 4.76 (21.52) | (0, 1) |
 No change | 41 | 4.07 (13.32) | (1, 8) | 2.44 (8.79) | (0, 5) | 47 | 0 (0) | (NA) | −0.71 (4.86) | (−2, 0) |
 Little better | 58 | 1.15 (22.48) | (−4, 6) | 1.72 (15.82) | (−2, 5) | 66 | 1.52 (9.12) | (0, 3) | 0.51 (16) | (−3, 4) |