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Table 3 The Response shift effect for the QLQ-BR23 questionnaire after three and six months for all patients and three main categories of the anchor

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

 

After 3 months

After 6 months

Between T0 and T1

Between T1 and T2

QLQ-BR23

N

RS (SD)

95%CI

P-value

ES

N

RS (SD)

95%CI

P-value

ES

Body image

232

6.50 (20.73)

 

0.01

0.37

232

−7.18 (22.33)

 

0.01

−0.23

 Little worse

70

5.04 (17.89)

(1, 9)

0.11

0.32

47

−11.17 (21.1)

(−16, −6)

0.03

−0.37

 No change

41

3.25 (14.54)

(−1, 7)

0.11

0.20

46

−3.62 (12.25)

(−7, −1)

0.28

−0.19

 Little better

49

9.98 (23)

(4, 15)

0.11

0.62

65

−2.74 (24.7)

(−8, 2)

0.63

−0.09

Sexual functioning

198

0.76 (15.06)

 

0.77

0.03

198

4.29 (18.88)

 

0.10

0.19

 Little worse

56

0.60 (15.56)

(−3, 4)

0.90

0.02

38

10.96 (19.86)

(6, 16)

0.07

0.52

 No change

34

1.96 (15.77)

(−3, 7)

0.73

0.08

41

0.41 (18.44)

(−4, 5)

0.90

0.01

 Little better

43

−1.94 (12.71)

(−5, 1)

0.77

−0.08

56

0.89 (16.02)

(−3, 4)

0.88

0.05

Sexual enjoyment

74

−4.05 (20.74)

 

0.26

−0.16

74

3.15 (23.49)

 

0.21

0.13

 Little worse

23

−2.90 (24.44)

(−12, 6)

0.59

−0.16

16

2.08 (30.96)

(−11, 16)

0.55

0.10

 No change

16

−6.25 (13.44)

(−12, 0)

0.51

−0.23

23

1.45 (25.58)

(−8, 11)

0.69

0.06

 Little better

11

−3.03 (23.35)

(−16, 10)

0.80

−0.10

16

2.08 (14.75)

(−4, 9)

0.83

0.08

Future perspectives

236

−7.91 (30.3)

 

0.01

−0.27

236

1.27 (30.77)

 

0.64

0.04

 Little worse

68

−16.18 (27.31)

(−22, −11)

0

−0.56

48

−4.17 (31.98)

(−12, 4)

0.49

−0.13

 No change

43

−13.18 (29.22)

(−21, −6)

0.04

−0.47

49

4.76 (34.69)

(−4, 13)

0.47

0.18

 Little better

48

−6.94 (32.95)

(−15, 1)

0.22

−0.28

63

7.41 (25.71)

(2, 13)

0.18

0.23

Systemic therapy side effects

252

0.42 (12.32)

 

0.73

0.03

252

8.16 (16.76)

 

0

0.42

 Little worse

72

0.96 (12.49)

(−1, 3)

0.78

0.07

53

13.76 (19.15)

(9, 18)

0

0.73

 No change

45

−0.56 (8.12)

(−3, 1)

0.90

−0.04

52

2.22 (8.64)

(0, 4)

0.53

0.19

 Little better

54

0 (12.64)

(−3, 3)

0.47

0

65

8.13 (19.39)

(4, 12)

0

0.45

Breast symptoms

212

−2.59 (19.13)

 

0.69

−0.18

212

8.54 (20.19)

 

0

0.35

 Little worse

57

4 (17.94)

(0, 8)

0.09

0.24

47

10.76 (19.94)

(6, 16)

0.01

0.4

 No change

36

−0.62 (11.35)

(−4, 3)

0.68

−0.07

42

7.34 (16.22)

(3, 12)

0.02

0.47

 Little better

53

−9.49 (21.49)

(−14, −5)

0.12

−0.76

59

5.84 (14.8)

(3, 9)

0.17

0.23

Arm symptoms

235

−1.94 (16.33)

 

0.50

−0.14

235

3.81 (19.17)

 

0.02

0.21

 Little worse

67

0.66 (18)

(−3, 4)

0.55

0.05

48

10.19 (20.06)

(5, 15)

0

0.47

 No change

41

1.36 (7.93)

(−1, 3)

0.31

0.16

50

4 (10.88)

(1, 7)

0.01

0.36

 Little better

55

−3.13 (18.07)

(−7, 1)

0.45

−0.18

64

0 (17.51)

(−4, 4)

0.71

0

  1. RS response shift, SD standard deviation, CI confidence interval, ES effect size