| After 3 months | After 6 months | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Between T0 and T1 | Between T1 and T2 | |||||||||
QLQ-BR23 | N | RS (SD) | 95%CI | P-value | ES | N | RS (SD) | 95%CI | P-value | ES |
Body image | 232 | 6.50 (20.73) |  | 0.01 | 0.37 | 232 | −7.18 (22.33) |  | 0.01 | −0.23 |
 Little worse | 70 | 5.04 (17.89) | (1, 9) | 0.11 | 0.32 | 47 | −11.17 (21.1) | (−16, −6) | 0.03 | −0.37 |
 No change | 41 | 3.25 (14.54) | (−1, 7) | 0.11 | 0.20 | 46 | −3.62 (12.25) | (−7, −1) | 0.28 | −0.19 |
 Little better | 49 | 9.98 (23) | (4, 15) | 0.11 | 0.62 | 65 | −2.74 (24.7) | (−8, 2) | 0.63 | −0.09 |
Sexual functioning | 198 | 0.76 (15.06) | Â | 0.77 | 0.03 | 198 | 4.29 (18.88) | Â | 0.10 | 0.19 |
 Little worse | 56 | 0.60 (15.56) | (−3, 4) | 0.90 | 0.02 | 38 | 10.96 (19.86) | (6, 16) | 0.07 | 0.52 |
 No change | 34 | 1.96 (15.77) | (−3, 7) | 0.73 | 0.08 | 41 | 0.41 (18.44) | (−4, 5) | 0.90 | 0.01 |
 Little better | 43 | −1.94 (12.71) | (−5, 1) | 0.77 | −0.08 | 56 | 0.89 (16.02) | (−3, 4) | 0.88 | 0.05 |
Sexual enjoyment | 74 | −4.05 (20.74) |  | 0.26 | −0.16 | 74 | 3.15 (23.49) |  | 0.21 | 0.13 |
 Little worse | 23 | −2.90 (24.44) | (−12, 6) | 0.59 | −0.16 | 16 | 2.08 (30.96) | (−11, 16) | 0.55 | 0.10 |
 No change | 16 | −6.25 (13.44) | (−12, 0) | 0.51 | −0.23 | 23 | 1.45 (25.58) | (−8, 11) | 0.69 | 0.06 |
 Little better | 11 | −3.03 (23.35) | (−16, 10) | 0.80 | −0.10 | 16 | 2.08 (14.75) | (−4, 9) | 0.83 | 0.08 |
Future perspectives | 236 | −7.91 (30.3) |  | 0.01 | −0.27 | 236 | 1.27 (30.77) |  | 0.64 | 0.04 |
 Little worse | 68 | −16.18 (27.31) | (−22, −11) | 0 | −0.56 | 48 | −4.17 (31.98) | (−12, 4) | 0.49 | −0.13 |
 No change | 43 | −13.18 (29.22) | (−21, −6) | 0.04 | −0.47 | 49 | 4.76 (34.69) | (−4, 13) | 0.47 | 0.18 |
 Little better | 48 | −6.94 (32.95) | (−15, 1) | 0.22 | −0.28 | 63 | 7.41 (25.71) | (2, 13) | 0.18 | 0.23 |
Systemic therapy side effects | 252 | 0.42 (12.32) | Â | 0.73 | 0.03 | 252 | 8.16 (16.76) | Â | 0 | 0.42 |
 Little worse | 72 | 0.96 (12.49) | (−1, 3) | 0.78 | 0.07 | 53 | 13.76 (19.15) | (9, 18) | 0 | 0.73 |
 No change | 45 | −0.56 (8.12) | (−3, 1) | 0.90 | −0.04 | 52 | 2.22 (8.64) | (0, 4) | 0.53 | 0.19 |
 Little better | 54 | 0 (12.64) | (−3, 3) | 0.47 | 0 | 65 | 8.13 (19.39) | (4, 12) | 0 | 0.45 |
Breast symptoms | 212 | −2.59 (19.13) |  | 0.69 | −0.18 | 212 | 8.54 (20.19) |  | 0 | 0.35 |
 Little worse | 57 | 4 (17.94) | (0, 8) | 0.09 | 0.24 | 47 | 10.76 (19.94) | (6, 16) | 0.01 | 0.4 |
 No change | 36 | −0.62 (11.35) | (−4, 3) | 0.68 | −0.07 | 42 | 7.34 (16.22) | (3, 12) | 0.02 | 0.47 |
 Little better | 53 | −9.49 (21.49) | (−14, −5) | 0.12 | −0.76 | 59 | 5.84 (14.8) | (3, 9) | 0.17 | 0.23 |
Arm symptoms | 235 | −1.94 (16.33) |  | 0.50 | −0.14 | 235 | 3.81 (19.17) |  | 0.02 | 0.21 |
 Little worse | 67 | 0.66 (18) | (−3, 4) | 0.55 | 0.05 | 48 | 10.19 (20.06) | (5, 15) | 0 | 0.47 |
 No change | 41 | 1.36 (7.93) | (−1, 3) | 0.31 | 0.16 | 50 | 4 (10.88) | (1, 7) | 0.01 | 0.36 |
 Little better | 55 | −3.13 (18.07) | (−7, 1) | 0.45 | −0.18 | 64 | 0 (17.51) | (−4, 4) | 0.71 | 0 |