Skip to main content

Table 3 The Response shift effect for the QLQ-BR23 questionnaire after three and six months for all patients and three main categories of the anchor

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

  After 3 months After 6 months
Between T0 and T1 Between T1 and T2
QLQ-BR23 N RS (SD) 95%CI P-value ES N RS (SD) 95%CI P-value ES
Body image 232 6.50 (20.73)   0.01 0.37 232 −7.18 (22.33)   0.01 −0.23
 Little worse 70 5.04 (17.89) (1, 9) 0.11 0.32 47 −11.17 (21.1) (−16, −6) 0.03 −0.37
 No change 41 3.25 (14.54) (−1, 7) 0.11 0.20 46 −3.62 (12.25) (−7, −1) 0.28 −0.19
 Little better 49 9.98 (23) (4, 15) 0.11 0.62 65 −2.74 (24.7) (−8, 2) 0.63 −0.09
Sexual functioning 198 0.76 (15.06)   0.77 0.03 198 4.29 (18.88)   0.10 0.19
 Little worse 56 0.60 (15.56) (−3, 4) 0.90 0.02 38 10.96 (19.86) (6, 16) 0.07 0.52
 No change 34 1.96 (15.77) (−3, 7) 0.73 0.08 41 0.41 (18.44) (−4, 5) 0.90 0.01
 Little better 43 −1.94 (12.71) (−5, 1) 0.77 −0.08 56 0.89 (16.02) (−3, 4) 0.88 0.05
Sexual enjoyment 74 −4.05 (20.74)   0.26 −0.16 74 3.15 (23.49)   0.21 0.13
 Little worse 23 −2.90 (24.44) (−12, 6) 0.59 −0.16 16 2.08 (30.96) (−11, 16) 0.55 0.10
 No change 16 −6.25 (13.44) (−12, 0) 0.51 −0.23 23 1.45 (25.58) (−8, 11) 0.69 0.06
 Little better 11 −3.03 (23.35) (−16, 10) 0.80 −0.10 16 2.08 (14.75) (−4, 9) 0.83 0.08
Future perspectives 236 −7.91 (30.3)   0.01 −0.27 236 1.27 (30.77)   0.64 0.04
 Little worse 68 −16.18 (27.31) (−22, −11) 0 −0.56 48 −4.17 (31.98) (−12, 4) 0.49 −0.13
 No change 43 −13.18 (29.22) (−21, −6) 0.04 −0.47 49 4.76 (34.69) (−4, 13) 0.47 0.18
 Little better 48 −6.94 (32.95) (−15, 1) 0.22 −0.28 63 7.41 (25.71) (2, 13) 0.18 0.23
Systemic therapy side effects 252 0.42 (12.32)   0.73 0.03 252 8.16 (16.76)   0 0.42
 Little worse 72 0.96 (12.49) (−1, 3) 0.78 0.07 53 13.76 (19.15) (9, 18) 0 0.73
 No change 45 −0.56 (8.12) (−3, 1) 0.90 −0.04 52 2.22 (8.64) (0, 4) 0.53 0.19
 Little better 54 0 (12.64) (−3, 3) 0.47 0 65 8.13 (19.39) (4, 12) 0 0.45
Breast symptoms 212 −2.59 (19.13)   0.69 −0.18 212 8.54 (20.19)   0 0.35
 Little worse 57 4 (17.94) (0, 8) 0.09 0.24 47 10.76 (19.94) (6, 16) 0.01 0.4
 No change 36 −0.62 (11.35) (−4, 3) 0.68 −0.07 42 7.34 (16.22) (3, 12) 0.02 0.47
 Little better 53 −9.49 (21.49) (−14, −5) 0.12 −0.76 59 5.84 (14.8) (3, 9) 0.17 0.23
Arm symptoms 235 −1.94 (16.33)   0.50 −0.14 235 3.81 (19.17)   0.02 0.21
 Little worse 67 0.66 (18) (−3, 4) 0.55 0.05 48 10.19 (20.06) (5, 15) 0 0.47
 No change 41 1.36 (7.93) (−1, 3) 0.31 0.16 50 4 (10.88) (1, 7) 0.01 0.36
 Little better 55 −3.13 (18.07) (−7, 1) 0.45 −0.18 64 0 (17.51) (−4, 4) 0.71 0
  1. RS response shift, SD standard deviation, CI confidence interval, ES effect size