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Table 2 The Response shift effect for the QLQ-C30 questionnaire after three and six months for all patients and three main categories of the anchor

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

QLQ-C30 After 3 months After 6 months
Between T0 and T1 Between T1 and T2
N RS (SD) 95%CI P-value ES N RS (SD) 95% CI P-value ES
GHS 251 3.82 (17.85)   0.02 0.20 251 −0.03 (21.04)   0.97 0
 Little worse 71 3.87 (15.86) (1, 7) 0.24 0.25 51 −8.33 (19.22) (−13, −4) 0.03 −0.42
 No change 43 6.78 (15.67) (3, 11) 0.08 0.40 50 8 (19.04) (3, 13) 0.03 0.42
 Little better 58 1.29 (17.51) (−3, 5) 0.67 0.08 67 −0.25 (21.61) (−5, 4) 0.80 −0.01
Physical functioning 255 1.54 (12.95)   0.30 0.11 255 −5.2 (12.86)   0 −0.32
 Little worse 73 −0.53 (11.11) (−3, 2) 0.49 −0.05 53 −9.56 (10.42) (−12, −7) 0 −0.52
 No change 46 1.30 (13.67) (−2, 5) 0.17 0.09 51 −2.29 (8.5) (−4, 0) 0.13 −0.26
 Little better 57 3.83 (14.47) (1, 7) 0.45 0.28 69 −3.94 (14.71) (−7, −1) 0.04 −0.25
Role functioning 253 6.06 (21.71)   0 0.32 253 −8.17 (27.07)   0 −0.29
 Little worse 73 6.62 (19.98) (3, 11) 0.04 0.46 51 −15.69 (28.95) (−22, −9) 0 −0.52
 No change 46 3.26 (16.34) (−1, 7) 0.07 0.19 51 −1.96 (18.45) (−6, 2) 0.67 −0.11
 Little better 55 10 (26.57) (4, 16) 0.05 0.45 68 −5.88 (26.67) (−11, 0) 0.24 −0.21
Emotional functioning 254 −7.56 (21.03)   0 −0.29 254 2.20 (22.68)   0.20 0.09
 Little worse 72 −9.34 (20.97) (−13, −5) 0 −0.38 52 −5.66 (19.77) (−10, −1) 0.16 −0.24
 No change 44 −8.52 (17.14) (−13, −4) 0.03 −0.42 50 8.94 (21.58) (4, 14) 0.04 0.47
 Little better 59 −11.11 (23.15) (−16, −6) 0.01 −0.43 69 5.68 (21.83) (1, 10) 0.10 0.23
Cognitive functioning 254 −3.94 (16.85)   0.01 −0.19 254 −3.08 (20.03)   0.04 −0.15
 Little worse 73 −5.48 (20.04) (−9, −2) 0.08 −0.26 52 −10.58 (21.9) (−16, −5) 0.02 −0.42
 No change 44 −1.52 (10.67) (−4, 1) 0.69 −0.11 50 −2.33 (16.5) (−6, 2) 0.35 −0.16
 Little better 57 −5.85 (19.29) (−10, −2) 0.08 −0.27 69 0.97 (18.28) (−3, 5) 0.98 0.05
Social functioning 249 5.09 (19.43)   0 0.28 249 −5.96 (24.47)   0.01 −0.23
 Little worse 72 5.32 (19.94) (1, 9) 0.05 0.39 52 −10.90 (25.54) (−17, −5) 0.02 −0.40
 No change 42 3.17 (14.37) (−1, 7) 0.08 0.24 49 −4.76 (16.67) (−9, −1) 0.40 −0.22
 Little better 59 3.67 (20.55) (−1, 8) 0.59 0.18 68 −1.23 (24.32) (−6, 4) 0.91 −0.05
Financial difficulties 240 −1.11 (15.32)   0.30 −0.08 240 2.50 (16.26)   0.22 0.12
 Little worse 69 −1.45 (12.04) (−4, 1) 0.58 −0.14 49 8.16 (24.09) (2, 14) 0.13 0.30
 No change 41 −1.63 (7.27) (−4, 0) 0.31 −0.31 47 −0.71 (4.86) (−2, 0) 0.57 −0.15
 Little better 58 0.57 (15.91) (−3, 4) 0.86 0.03 66 −1.01 (16.51) (−4, 2) 0.82 −0.05
Fatigue 254 −1.20 (19.42)   0.51 −0.06 254 10.83 (23.93)   0 0.41
 Little worse 73 −4.57 (21.36) (−9, 0) 0.31 −0.33 53 19.92 (23.23) (15, 25) 0 0.85
 No change 46 −2.17 (15.29) (−6, 2) 0.62 −0.12 51 3.70 (20.08) (−1, 8) 0.32 0.20
 Little better 57 −4.58 (21.29) (−9, 0) 0.35 −0.23 68 9.97 (23.76) (5, 15) 0.01 0.44
Nausea and vomiting 255 −1.37 (13.59)   0.26 −0.13 255 3.59 (17.65)   0 0.19
 Little worse 74 −0.45 (15.35) (−3, 3) 0.71 −0.05 53 4.09 (14.58) (1, 7) 0.09 0.26
 No change 46 0.72 (9.91) (−2, 3) 1 0.04 51 0.98 (10.23) (−1, 3) 0.10 0.10
 Little better 57 −5.26 (15.16) (−9, −2) 0.05 −0.87 70 6.67 (25.44) (2, 12) 0.05 29
Pain 260 −3.33 (22.51)   0.14 −0.16 260 5.83 (22.2)   0 0.23
 Little worse 75 −4.67 (21.32) (−9, −1) 0.29 −0.24 54 15.43 (26.27) (9, 21) 0 0.56
 No change 46 1.45 (18.2) (−3, 6) 0.83 0.09 52 2.24 (13.21) (−1, 5) 0.30 0.18
 Little better 57 −7.31 (23.57) (−13, −2) 0.16 −0.35 70 −0.24 (23.14) (−5, 4) 0.80 −0.01
Dyspnea 251 1.20 (15.16)   0.59 0.06 251 3.98 (22.4)   0.03 0.17
 Little worse 73 2.28 (15.04) (−1, 5) 0.38 0.11 52 3.85 (27.74) (−3, 10) 0.14 0.17
 No change 45 0 (12.31) (−3, 3) 0.77 0 51 0.65 (10.52) (−2, 3) 0.79 0.05
 Little better 55 0.61 (17.56) (−3, 5) 0.77 0.03 67 3.98 (22.11) (−1, 8) 0.51 0.17
Insomnia 249 6.83 (30.64)   0.01 0.22 249 3.08 (30.41)   0.30 0.10
 Little worse 69 2.42 (29.33) (−3, 8) 0.49 0.08 52 10.9 (37.18) (2, 2) 0.07 0.33
 No change 46 7.25 (26.21) (1, 14) 0.27 0.25 50 3.33 (25.42) (−3, 9) 0.24 0.18
 Little better 55 7.88 (37.93) (−1, 16) 0.11 0.27 67 −1.49 (29.83) (−8, 5) 0.74 −0.05
Appetite loss 249 2.28 (21.05)   0.23 0.11 249 4.69 (22.2)   0.03 0.19
 Little worse 73 0.91 (20.77) (−3, 5) 0.55 0.06 53 13.84 (24.84) (8, 20) 0 0.51
 No change 46 4.35 (13.35) (1, 8) 0.19 0.22 50 0.67 (15.78) (−3, 4) 0.98 0.03
 Little better 54 1.85 (22.82) (−3, 7) 0.79 0.09 68 1.96 (21.46) (−2, 6) 0.74 0.09
Constipation 247 0 (22.61)   0.87 0 247 4.18 (25.89)   0.05 0.16
 Little worse 68 −4.90 (18.45) (−9, −1) 0.19 −0.26 48 4.17 (25.38) (−2, 10) 0.29 0.16
 No change 42 2.38 (18.61) (−2, 7) 0.42 0.11 48 2.08 (14.43) (−1, 6) 0.43 0.15
 Little better 58 0 (27.22) (−6, 6) 0.87 0 70 2.86 (35.32) (−4, 10) 0.71 0.10
Diarrhea 248 2.42 (14.99)   0.09 0.15 248 0.94 (20.28)   0.42 0.06
 Little worse 71 3.29 (16.09) (0, 6) 0.28 0.18 48 3.47 (14.16) (0, 7) 0.22 0.23
 No change 43 1.55 (12.50) (−2, 5) 0.54 0.13 48 −0.69 (14.57) (−4, 3) 0.98 −0.07
 Little better 56 2.98 (17.15) (−1, 7) 0.34 0.16 69 0 (26.81) (−5, 5) 0.86 0
  1. GHS global health status, RS response shift, SD standard deviation, CI confidence interval, ES effect size