Table 2 The Response shift effect for the QLQ-C30 questionnaire after three and six months for all patients and three main categories of the anchor

GHS

251

3.82 (17.85)

0.02

0.20

251

−0.03 (21.04)

0.97

0

 Little worse

71

3.87 (15.86)

(1, 7)

0.24

0.25

51

−8.33 (19.22)

(−13, −4)

0.03

−0.42

 No change

43

6.78 (15.67)

(3, 11)

0.08

0.40

50

8 (19.04)

(3, 13)

0.03

0.42

 Little better

58

1.29 (17.51)

(−3, 5)

0.67

0.08

67

−0.25 (21.61)

(−5, 4)

0.80

−0.01

Physical functioning

255

1.54 (12.95)

0.30

0.11

255

−5.2 (12.86)

0

−0.32

 Little worse

73

−0.53 (11.11)

(−3, 2)

0.49

−0.05

53

−9.56 (10.42)

(−12, −7)

0

−0.52

 No change

46

1.30 (13.67)

(−2, 5)

0.17

0.09

51

−2.29 (8.5)

(−4, 0)

0.13

−0.26

 Little better

57

3.83 (14.47)

(1, 7)

0.45

0.28

69

−3.94 (14.71)

(−7, −1)

0.04

−0.25

Role functioning

253

6.06 (21.71)

0

0.32

253

−8.17 (27.07)

0

−0.29

 Little worse

73

6.62 (19.98)

(3, 11)

0.04

0.46

51

−15.69 (28.95)

(−22, −9)

0

−0.52

 No change

46

3.26 (16.34)

(−1, 7)

0.07

0.19

51

−1.96 (18.45)

(−6, 2)

0.67

−0.11

 Little better

55

10 (26.57)

(4, 16)

0.05

0.45

68

−5.88 (26.67)

(−11, 0)

0.24

−0.21

Emotional functioning

254

−7.56 (21.03)

0

−0.29

254

2.20 (22.68)

0.20

0.09

 Little worse

72

−9.34 (20.97)

(−13, −5)

0

−0.38

52

−5.66 (19.77)

(−10, −1)

0.16

−0.24

 No change

44

−8.52 (17.14)

(−13, −4)

0.03

−0.42

50

8.94 (21.58)

(4, 14)

0.04

0.47

 Little better

59

−11.11 (23.15)

(−16, −6)

0.01

−0.43

69

5.68 (21.83)

(1, 10)

0.10

0.23

Cognitive functioning

254

−3.94 (16.85)

0.01

−0.19

254

−3.08 (20.03)

0.04

−0.15

 Little worse

73

−5.48 (20.04)

(−9, −2)

0.08

−0.26

52

−10.58 (21.9)

(−16, −5)

0.02

−0.42

 No change

44

−1.52 (10.67)

(−4, 1)

0.69

−0.11

50

−2.33 (16.5)

(−6, 2)

0.35

−0.16

 Little better

57

−5.85 (19.29)

(−10, −2)

0.08

−0.27

69

0.97 (18.28)

(−3, 5)

0.98

0.05

Social functioning

249

5.09 (19.43)

0

0.28

249

−5.96 (24.47)

0.01

−0.23

 Little worse

72

5.32 (19.94)

(1, 9)

0.05

0.39

52

−10.90 (25.54)

(−17, −5)

0.02

−0.40

 No change

42

3.17 (14.37)

(−1, 7)

0.08

0.24

49

−4.76 (16.67)

(−9, −1)

0.40

−0.22

 Little better

59

3.67 (20.55)

(−1, 8)

0.59

0.18

68

−1.23 (24.32)

(−6, 4)

0.91

−0.05

Financial difficulties

240

−1.11 (15.32)

0.30

−0.08

240

2.50 (16.26)

0.22

0.12

 Little worse

69

−1.45 (12.04)

(−4, 1)

0.58

−0.14

49

8.16 (24.09)

(2, 14)

0.13

0.30

 No change

41

−1.63 (7.27)

(−4, 0)

0.31

−0.31

47

−0.71 (4.86)

(−2, 0)

0.57

−0.15

 Little better

58

0.57 (15.91)

(−3, 4)

0.86

0.03

66

−1.01 (16.51)

(−4, 2)

0.82

−0.05

Fatigue

254

−1.20 (19.42)

0.51

−0.06

254

10.83 (23.93)

0

0.41

 Little worse

73

−4.57 (21.36)

(−9, 0)

0.31

−0.33

53

19.92 (23.23)

(15, 25)

0

0.85

 No change

46

−2.17 (15.29)

(−6, 2)

0.62

−0.12

51

3.70 (20.08)

(−1, 8)

0.32

0.20

 Little better

57

−4.58 (21.29)

(−9, 0)

0.35

−0.23

68

9.97 (23.76)

(5, 15)

0.01

0.44

Nausea and vomiting

255

−1.37 (13.59)

0.26

−0.13

255

3.59 (17.65)

0

0.19

 Little worse

74

−0.45 (15.35)

(−3, 3)

0.71

−0.05

53

4.09 (14.58)

(1, 7)

0.09

0.26

 No change

46

0.72 (9.91)

(−2, 3)

1

0.04

51

0.98 (10.23)

(−1, 3)

0.10

0.10

 Little better

57

−5.26 (15.16)

(−9, −2)

0.05

−0.87

70

6.67 (25.44)

(2, 12)

0.05

29

Pain

260

−3.33 (22.51)

0.14

−0.16

260

5.83 (22.2)

0

0.23

 Little worse

75

−4.67 (21.32)

(−9, −1)

0.29

−0.24

54

15.43 (26.27)

(9, 21)

0

0.56

 No change

46

1.45 (18.2)

(−3, 6)

0.83

0.09

52

2.24 (13.21)

(−1, 5)

0.30

0.18

 Little better

57

−7.31 (23.57)

(−13, −2)

0.16

−0.35

70

−0.24 (23.14)

(−5, 4)

0.80

−0.01

Dyspnea

251

1.20 (15.16)

0.59

0.06

251

3.98 (22.4)

0.03

0.17

 Little worse

73

2.28 (15.04)

(−1, 5)

0.38

0.11

52

3.85 (27.74)

(−3, 10)

0.14

0.17

 No change

45

0 (12.31)

(−3, 3)

0.77

0

51

0.65 (10.52)

(−2, 3)

0.79

0.05

 Little better

55

0.61 (17.56)

(−3, 5)

0.77

0.03

67

3.98 (22.11)

(−1, 8)

0.51

0.17

Insomnia

249

6.83 (30.64)

0.01

0.22

249

3.08 (30.41)

0.30

0.10

 Little worse

69

2.42 (29.33)

(−3, 8)

0.49

0.08

52

10.9 (37.18)

(2, 2)

0.07

0.33

 No change

46

7.25 (26.21)

(1, 14)

0.27

0.25

50

3.33 (25.42)

(−3, 9)

0.24

0.18

 Little better

55

7.88 (37.93)

(−1, 16)

0.11

0.27

67

−1.49 (29.83)

(−8, 5)

0.74

−0.05

Appetite loss

249

2.28 (21.05)

0.23

0.11

249

4.69 (22.2)

0.03

0.19

 Little worse

73

0.91 (20.77)

(−3, 5)

0.55

0.06

53

13.84 (24.84)

(8, 20)

0

0.51

 No change

46

4.35 (13.35)

(1, 8)

0.19

0.22

50

0.67 (15.78)

(−3, 4)

0.98

0.03

 Little better

54

1.85 (22.82)

(−3, 7)

0.79

0.09

68

1.96 (21.46)

(−2, 6)

0.74

0.09

Constipation

247

0 (22.61)

0.87

0

247

4.18 (25.89)

0.05

0.16

 Little worse

68

−4.90 (18.45)

(−9, −1)

0.19

−0.26

48

4.17 (25.38)

(−2, 10)

0.29

0.16

 No change

42

2.38 (18.61)

(−2, 7)

0.42

0.11

48

2.08 (14.43)

(−1, 6)

0.43

0.15

 Little better

58

0 (27.22)

(−6, 6)

0.87

0

70

2.86 (35.32)

(−4, 10)

0.71

0.10

Diarrhea

248

2.42 (14.99)

0.09

0.15

248

0.94 (20.28)

0.42

0.06

 Little worse

71

3.29 (16.09)

(0, 6)

0.28

0.18

48

3.47 (14.16)

(0, 7)

0.22

0.23

 No change

43

1.55 (12.50)

(−2, 5)

0.54

0.13

48

−0.69 (14.57)

(−4, 3)

0.98

−0.07

 Little better

56

2.98 (17.15)

(−1, 7)

0.34

0.16

69

0 (26.81)

(−5, 5)

0.86

0