Health-related quality of life in Hodgkin lymphoma: a systematic review

Linendoll, Nadine; Saunders, Tully; Burns, Rebecca; Nyce, Jonathan D.; Wendell, Kristen B.; Evens, Andrew M.; Parsons, Susan K.

doi:10.1186/s12955-016-0515-6

Table 2 Studies assessing HRQL in Hodgkin lymphoma patients (N = 65)

Primary Author	Year	Design	Study Type	Timepoints (as reported)	N (HL Specific)	Age (HL specific)	Tx Status	Measures	Domains Assessed	Quality Score
Fobair P [26]	1986	Cohort	Cross-sectional	Median 9 years post treatment	403	36.3 mean	Off	CES-D, Study-specific questionnaire	Domain, Symptom	6
Kornblith AB [22]	1990	Cohort	Cross-sectional	6.3 years mean post treatment	273	37 mean	Off	PAIS-SR, BSI, POMS, IES, Global Sexual Satisfaction Index	Domain	5
Chao NJ [37]	1992	Cohort	Longitudinal	<1 year post treatment	24	N/S	Off	Study-specific questionnaire	MultiD	2
Kornblith AB [23]	1992	Cohort	Cross-sectional	Mean 6.3 years post treatment	273	37 mean	Off	PAIS-SR, BSI, POMS, Global Sexual Satisfaction Index	Domain	6
Kornblith [48] AB	1992	Cohort	Cross-sectional	Mean 2.2 years post treatment	93	35 median	Off	PAIS-SR, BSI, POMS, IES	Domain	4
Bloom JR [49]	1993	Comparator: Cohort	Cross-sectional	1 or more years post treatment	85	32.3 mean	Off	POMS, CES-D, Social Activity Scale	Domain	6
van Tulder MW [30]	1994	Comparator: Cohort	Cross-sectional	Mean 14 years since diagnosis	81	43.6 mean	Off	SF-36, Maudsley Martital Questionnaire	MultiD, Other	6
Joly F [38]	1996	Comparator: Case Control	Cross-sectional	Mean 10 years since diagnosis	93	42 mean	Off	EORTC QLQ-C30, Study-specific questionnaire	MultiD, Other	6
Norum J [50]	1996	Cohort	Cross-sectional	Median 48 months since diagnosis	42	38 median	Off	IES, VAS	Domain, Other	4
Norum J [51]	1996	Cohort	Cross-sectional	Median 48 months since diagnosis	42	38 median	Off	EuroQol	MultiD	4
Norum J [52]	1996	Cohort	Cross-sectional	Median 48 months since diagnosis	42	38 median	Off	EORTC QLQ-C30	MultiD	3
Abrahamsen AF [29]	1998	Cohort	Cross-sectional	Mean 12 years since diagnosis	459	44 median	Off	Study-specific questionnaire	Domain	6
Kornblith AB [24]	1998	Comparator: Cohort	Cross-sectional	Mean 5.9 years post treatment	273	37 median	Off	PAIS-SR, BSI, POMS, IES	Domain	6
Greil R [13]	1999	Cohort	Cross-sectional	Mean 10.5 years since diagnosis	126	36.9 mean	Off	EORTC QLQ-C30	MultiD	6
Kaasa S [53]	1999	Comparator: Cohort	Cross-sectional	3–20 years post treatment	459	44 mean	Off	SF-36, FQ	MultiD, Symptoms	5
Loge JH [54]	1999	Cohort	Cross-sectional	Mean 12.2 years since diagnosis	459	44 mean	Off	HADS, FQ	Domain, Symptom	6
Loge JH [55]	1999	Cohort	Cross-sectional	Mean 12.2 years since diagnosis	459	44 mean	Off	SF-36	MultiD	6
Van Schaik CS [56]	1999	Cohort	Cross-sectional	Median 21.9 years since diagnosis	33	21.9 median	Off	HUI2, HUI3	MultiD	3
Loge JH [32]	2000	Cohort	Cross-sectional	3–23 years post treatment	421	19–74 years	Off	FQ, HADS, Study-specific questionnaire	Domain. Symptom	6
Barr RD [57]	2001	Comparator: Cohort	Cross-sectional	Completed treatment at least 2 years prior	19	N/S	Off	HUI	MultiD	2
Cameron CL [58]	2001	Cohort	Cross-sectional	Median 7 years since diagnosis	272	37 mean	Off	PAIS-SR, Symptom Report	Domain, Symptom	4
Knobel H [35]	2001	Cohort	Cross-sectional	Mean 9 years since diagnosis	92	37 mean	Off	FQ	Symptom	6
Zabora J [59]	2001	Cohort	Cross-sectional	58 % diagnosed within 90 days from study	135	N/S	Both	BSI	Domain	3
Zebrack BJ [43]	2002	Comparator: Cohort	Cross-sectional	Mean 16.2 years since diagnosis	1843	30.8 mean	Off	BSI	Domain	5
Ganz PA [10]	2003	Comparator: RCT	Longitudinal	Trial registration (since diagnosis)	244	31.4 STLI, 33.7 CMT median	Both	SF-36, CARES-SF, SDS	MultiD, Symptom	4
Gil-Fernández JJ [27]	2003	Cohort	Cross-sectional	Median 7.6 years since diagnosis	46	43 mean	Off	EORTC QLQ-C30, HADS	MultiD, Other	5
Oldervoll LM [36]	2003	Cohort	Longitudinal	Mean post treatment: 6.6 years fatigued patients; 4.9 years non-fatigued patients	53	41 fatigue, 40 non-fatigued mean	Off	SF-36, FQ	MultiD, Symptom	5
Rüffer JU [33]	2003	Comparator: Case Control	Cross-sectional	Median 5.2 years since diagnosis	818	31 median	Off	EORTC QLQ-C30, MFI, Life Situation Questionnaire	MultiD, Symptom	5
Wettergren L [60]	2003	Cohort	Cross-sectional	Mean 14 years since diagnosis	121	47 mean	Off	SEIQol-DW	MultiD	5
Adams MJ [16]	2004	Cohort	Cross-sectional	Median 14.3 years since diagnosis	48	31.9 median	Off	SF-36, Study-specific questionnaire	MultiD	4
Wettergren L [28]	2004	Cohort	Cross-sectional	Mean 13 years since diagnosis	121	47 median	Off	SF-12, SEIQoL-DW, HADS	MultiD, Domain	6
Hjermstad MJ [61]	2005	Cohort	Cross-sectional	Median 16.3 years since diagnosis	496	46 median	Off	FQ	Symptom	6
Ng AK [34]	2005	Comparator: Cohort	Cross-sectional	Median 15 years since diagnosis	511	44 median	Off	FACIT-Fatigue	Symptom	6
Wettergren L [62]	2005	Cohort	Cross-sectional	Median 14 years since diagnosis	121	NS	Off	SF-12, SEIQoL-DW	MultiD	2
Hjermstad MJ [63]	2006	Cohort	Cross-sectional	Median 16.3 years since diagnosis	479	46 mean	Off	SF-36, FQ	MultiD, Symptom	5
Mols F [21]	2006	Cohort	Cross-sectional	5–15 years since diagnosis	132	NS	Off	SF-36, QoL-CS	MultiD	6
Absolom K [64]	2007	Cohort	Cross-sectional	15.7 years mean since diagnosis	50	39.7 mean	Off	SF-12, HADS	MultiD, Domain	5
Aksnes LH [65]	2007	Comparator: Cohort	Cross-sectional	Mean since diagnosis: 14 years for males, 11 years for females	89	35 mean	Off	SF-36, HADS, FQ	MultiD, Domain, Symptom	4
Oldervoll LM [66]	2007	Cohort	Cross-sectional	Mean 17 years since diagnosis	476	46 mean	Off	FQ	Symptom	5
Goodman KA [19]	2008	Cohort	Cross-sectional	Median 12 years post treatment	60	43 median	Off	EORTC QLQ-C30	MultiD	6
Mulrooney DA [67]	2008	Comparator: Cohort	Cross-sectional	At least 15 years since diagnosis	995	NS	Off	FACIT-Fatigue, Pittsburgh Slee Quality Index, Epworth Sleepiness Scale	Symptoms	4
Shimoda S [68]	2008	Cohort	Cross-sectional	Mean 16.5 years since diagnosis	15	NS	Off	HUI3	MultiD	2
Kiserud CE [14]	2009	Cohort	Cross-sectional	Mean 15.2 follow up years	138	45.7 mean	Off	BSFI, Fatigue questionnaire, HADS, SF-36	MultiD, Symptom, Domain	6
Heutte N [11]	2009	Comparator: RCT	Longitudinal	Mean 7.5 years since diagnosis	935	31 median	Off	EORTC QLQ-C30, MFI, Sexual Function Scale	MultiD, Symptoms	6
Brandt J [69]	2010	Cohort	Cross-sectional	Median since diagnosis: HDCT 11 years, conventional chemotherapy 3.5 years	98	46 HDCT, 41 conventional median	Off	EORTC QLQ-C30, EQ-5D	MultiD	6
Klaassen RJ [40]	2010	Cohort	Longitudinal	2 weeks after first course of chemotherapy	49	14.7 mean	Both	PedsQL, HUI2, HUI3, EuroQol, Lanksy Play-Performance Score	MultiD, Other	4
Klaassen RJ [41]	2010	Comparator: Cohort	Longitudinal	2 weeks after first course of chemotherapy	49	14.7 mean	Both	PedsQL, HUI2, HUI3, EuroQol, Lanksy Play-Performance Score	MultiD, Other	2
Miltényi Z [17]	2010	Cohort	Cross-sectional	Mean 9.8 years since diagnosis	168	43.11 median	Off	EORTC QLQ-C30	MultiD	6
Baptista RLR [70]	2012	Cohort	Cross-sectional	Median 7 years since diagnosis	200	29 median	Off	MFI	Symptom	4
Khimani N [18]	2013	Cohort	Longitudinal	Median 24 years since diagnosis	273	52 median	Off	SF-36, FACIT-Fatigue	MultiD, Symptom	5
Minn AY [20]	2012	Cohort	Cross-sectional	Median 10.2 years post treatment	71	26 median	Off	EORTC QLQ-C30	MultiD	5
Behringer K [12]	2013	Comparator: RCT	Longitudinal	At diagnosis	3208	36.4 mean	Both	EORTC QLQ-C30, MFI, Sexual Health Scale	MultiD, Symptoms	6
Greaves P [39]	2014	Comparator: Cohort	Cross-sectional	Mean 20.3 years since diagnosis	280	53.1 mean	Off	FACT-BMT, IOC, Study-specific questionnaire	MultiD, Other	5
Hamre H [44]	2013	Comparator: Cohort	Cross-sectional	Median 21.5 years since diagnosis	68	35 median	Off	FQ	Symptom	5
Kim S [71]	2014	Cohort	Cross-sectional	Mean 6.7 years since diagnosis	58	43.3 mean	Off	EORTC QLQ-C30, HADS	MultiD, Domain	6
Roper K [72]	2013	Cohort	Longitudinal	At completion of planned therapy	40	30.9 mean	Off	SF-12, HADS, SDS, IOC	MultiD, Domain, Other	4
Soares A [45]	2013	Cohort	Cross-sectional	Median 7 years since diagnosis	200	29 median	Off	SF-12, QOL-CS, MOS-SSS, MFI	MultiD, Symptom	4
Vissers PAJ [15]	2013	Cohort	Cross-sectional	Mean 5 years since diagnosis	150	47 mean	Off	EORTC QLQ-C30	MultiD	6
Calaminus G [46]	2014	Cohort	Cross-sectional	Mean 15.3 years since diagnosis	725	28.44 mean	Off	EORTC QLQ-C30	MultiD	6
Daniels LA [31]	2014	Cohort	Cross-sectional	Mean 4.6 years since diagnosis	180	46 mean	Off	EORTC QLQ-C30, Fatigue Assessment Scale, Study-specific questionnaire	MultiD, Symtom, Domain	6
Daniels LA [73]	2014	Cohort	Longitudinal	Mean 21 years since diagnosis	43	47 mean	Off	EORTC QLQ-C30, Fatigue Assessment Scale, HADS	MultiD, Domain, Symptom	4
Oerlemans S [25]	2014	Comparator: Case Control	Longitudinal	Mean 4.7 years since diagnosis	180	46.1 mean	Off	EORTC QLQ-C30, HADS	MultiD, Domain	6
Vermaete N [47]	2014	Comparator: Cohort	Longitudinal	Before the start of chemotherapy	12	47 mean	Both	EORTC QLQ-C30, Distress Barometer	MultiD, Domain	5
Kiserud CE [74]	2015	Cohort	Cross-sectional	Median 16 years since diagnosis	131	46 median	Off	Fatigue questionnaire, HADS, SF36,	Symptom, MultiD	5
Husson O [42]	2015	Comparator: Cohort	Cross-sectional	Mean 5.3 years since diagnosis	150	46.6 mean	Off	Fatigue assessment scale	Symptom	4

Abbreviations: Tx treatment, MultiD multidimensional, HL Hodgkin’s Lymphoma, RCT randomized controlled trial, EORTC QLQ-C30 European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, SF-36/SF-12 Short Form, HUI Health Utilities Index, QOL-CS Quality of Life-Cancer Survivors, CES-D Center for Epidemiologic Studies Depression Scale, GSSI Global Sexual Satisfaction Index, IES Impact of Event Scale, VAS Visual Analogue Scale, CARES-SF Cancer Rehabilitation Evaluation System-Short Form, SDS Symptom Distress Scale, SEIQol-DW Schedule for the Evaluation of the Individual Quality of Life-Direct Weighting, PedsQL Pediatric Quality of Life Inventory, MOS-SSS Medical Outcomes Study-Social Support Survey, FACT-BMT Functional Assessment of Cancer Therapy—Bone Marrow Transplant, FQ Fatigue Questionnaire, MFI Multi-Dimensional Fatigue Inventory, FACIT-Fatigue Functional Assessment of Chronic Illness Therapy-Fatigue, HADS Hospital Anxiety and Depression Scale, BSI Brief Symptom Inventory, POMS Profile of Mood States, PAIS Psychosocial Adjustment to Illness Scale, HDCT high dose chemotherapy, STLI subtotal lymphoid irradiation, CMT combined modality treatment, NS not stated

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