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Table 3 Mean OPAQ-PF total scores at baseline, change scores, and effect sizes at weeks 2 (no recent fracture patients and 12 (recent fracture patients) by patient global ratings of change at weeks 2 and 12

From: Interpreting change from patient reported outcome (PRO) endpoints: patient global ratings of concept versus patient global ratings of change, a case study among osteoporosis patients

 

No recent fracture patients (N = 105)

Recent fracture patients (N = 34)

Rating of change

 

Baseline

2 weeks

Effect sizea for OPAQ-PF change

 

Baseline

12 weeks

Effect sizea for OPAQ-PF change

N

OPAQ-PF total score

mean (SD)

OPAQ-PF mean change (SD)

N

OPAQ-PF total score

mean (SD)

OPAQ-PF mean change (SD)

Mobility

 Much better

4

91.3 (7.96)

−0.67 (4.93)

−0.08

12

70.4 (25.8)

19.9 (27.9)

0.77

 Moderately better

5

89.6 (11.2)

−4.53 (5.47)

−0.40

6

42.7 (20.4)

29.1 (19.4)

1.43

 A little better

4

89.7 (9.70)

−8.00 (13.5)

−0.82

3

61.3 (26.0)

−1.78 (47.2)

−0.07

 No change

79

82.5 (22.1)

−0.38 (9.23)

−0.02

8

51.3 (27.5)

6.83 (10.7)

0.25

 A little worse

10

77.3 (14.0)

−10.7 (14.4)

−0.76

3

64.9 (21.6)

−4.89 (16.0)

−0.23

 Moderately worse

2

38.7 (17.0)

−1.33 (11.3)

−0.08

2

56.0 (3.8)

12.7 (23.6)

3.34

 Much worse

1

22.7 (−)

−14.7 (−)

-

-

-

-

-

 

K-W test p-value

0.148

   

0.24

 
 

Linear trend p-value

(departures from linear trend)

0.33 (0.033)

   

0.086 (0.49)

 
 

rs

(p-value)

−0.082 (0.405)

   

0.322 (0.064)

 

Physical Positions

 Much better

3

92.0 (9.61)

1.33 (3.53)

0.14

12

70.6 (25.6)

21.9 (28.7)

0.86

 Moderately better

3

89.8 (14.4)

−5.78 (6.84)

−0.40

3

38.2 (6.30)

38.7 (16.2)

6.14

 A little better

6

91.6 (6.29)

−8.44 (8.95)

−1.34

4

39.3 (17.7)

19.7 (11.4)

1.11

 No change

81

82.7 (21.6)

−0.87 (9.58)

−0.04

8

52.5 (28.5)

8.67 (8.58)

0.30

 A little worse

8

77.3 (12.6)

−7.83 (16.0)

−0.62

7

66.3 (16.6)

−7.62 (26.2)

−0.46

 Moderately worse

3

40.9 (12.6)

0 (8.33)

0.0

-

-

-

-

 Much worse

1

22.7 (−)

−14.7 (−)

-

-

-

-

-

 

K-W test p-value

0.224

   

0.033

 
 

Linear trend p-value

(departures from linear trend)

0.631 (0.131)

   

0.007 (0.310)

 
 

rs

(p-value)

0.042 (0.673)

   

0.447 (0.008)

 

Transfersb

 Much better

3

89.3 (14.1)

−2.67 (9.61)

−0.19

12

65.1 (26.3)

24.6 (29.2)

0.94

 Moderately better

3

90.7 (8.74)

−3.56 (3.36)

−0.41

3

42.2 (5.39)

33.8 (7.81)

6.27

 A little better

5

94.7 (4.62)

−8.80 (9.96)

−1.90

4

50.3 (30.6)

1.33 (39.0)

0.04

 No change

88

82.2 (21.3)

−0.87 (9.31)

−0.04

11

61.9 (26.9)

6.30 (14.4)

0.10

 A little worse

3

70.7 (7.42)

−18.2 (23.3)

−2.45

2

59.3 (27.3)

3.33 (10.4)

0.12

 Moderately worse

2

38.7 (17.0)

−1.33 (11.3)

−0.08

1

58.7

−4.0

-

 Much worse

1

22.7 (−)

14.7 (−)

-

-

-

-

-

 

K-W test p-value

0.304

   

0.133

 
 

Linear trend p-value

(departures from linear trend)

0.655 (0.026)

   

0.030 (0.740)

 
 

rs

(p-value)

0.028 (0.777)

   

0.426 (0.013)

 
  1. Data are shown for patients with data at each two assessments
  2. aCohen’s d effect size = mean change / baseline SD
  3. b N = 33 (recent fracture)