Table 8 External responsiveness of all PROMs

EQ-5D-3 L

N

6 months

12 months

P value

Difference

SRM

Cohen’s D

 Much Better

6

0.75

0.88

0.009

0.13

4.09

4.07

4.12

0.85

 Better

33

0.67

0.75

0.028

0.08

2.30

2.28

2.31

0.31

 Same

79

0.65

0.63

0.448

−0.02

−0.76

−0.77

−0.76

0.06

 Worse

31

0.55

0.54

0.686

−0.02

−0.41

−0.42

−0.39

0.05

 Much Worse

2

0.69

0.51

0.500

−0.18

−1.00

−1.25

−0.75

0.31

SF-6D

N

6 Months

12 Months

P Value

Difference

SRM

Cohen’s D

 Much Better

6

0.71

0.74

0.592

0.03

0.57

0.53

0.62

0.21

 Better

37

0.69

0.73

0.014

0.05

2.58

2.58

2.59

0.32

 Same

74

0.67

0.69

0.045

0.02

2.04

2.05

2.05

0.15

 Worse

28

0.66

0.67

0.814

0.00

0.23

0.23

0.25

0.04

 Much Worse

2

0.69

0.60

0.205

−0.09

−3.00

−3.04

−2.96

0.41

SF-12 PCS

N

6 Months

12 Months

P Value

Difference

SRM

Cohen’s D

 Much Better

6

35.60

50.40

0.004

14.80

4.95

2.56

7.34

1.36

 Better

36

35.07

41.65

0.000

6.58

4.79

4.34

5.24

0.52

 Same

71

38.32

40.63

0.002

2.13

2.87

2.70

3.05

0.19

 Worse

26

37.45

35.15

0.1517

−2.30

−1.48

−2.08

−0.88

0.18

 Much Worse

2

44.01

31.63

0.366

−12.38

−1.54

−12.66

9.57

1.37

SF-12 MCS

N

6 Months

12 Months

P Value

Difference

SRM

Cohen’s D

 Much Better

6

49.81

49.39

0.897

−0.42

−0.14

−2.59

2.32

0.03

 Better

36

48.15

50.21

0.222

2.06

1.24

−0.70

1.79

0.16

 Same

71

44.53

45.24

0.502

0.72

0.68

0.43

0.92

0.05

 Worse

26

49.29

46.76

0.226

−2.53

−1.24

−2.02

−0.46

0.20

 Much Worse

2

40.00

44.28

0.707

4.28

0.50

−11.46

12.45

0.17

SGRQ Total Score

N

6 Months

12 Months

P Value

Difference

SRM

Cohen’s D

 Much Better

4

20.54

13.64

0.012

−6.91

−5.10

−3.77

−6.43

0.54

 Better

24

26.50

24.14

0.279

−2.37

−1.11

−0.26

−1.96

0.11

 Same

50

30.00

30.53

0.789

0.53

0.27

0.82

−0.28

0.02

 Worse

18

36.84

38.14

0.540

2.30

0.63

2.32

−1.07

0.09

 Much Worse

1

19.37

54.48

N/A

35.11

N/A

N/A

N/A

N/A