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Table 2 Mean differences compared with odds ratios

From: Interpreting small treatment differences from quality of life data in cancer trials: an alternative measure of treatment benefit and effect size for the EORTC-QLQ-C30

   Odds ratio Mean Difference (MD)
Study QLQ-C30 Odds Ratio Lower 95 % CI Upper 95 % CI P-value Difference Lower 95 % CI Upper 95 % CI P-value
TOPICAL QL 0.99840 0.92173 1.08145 0.4687 0.6433 −1.4409 2.7274 0.5450
(N = 670) PF 1.10396 1.01803 1.19714 0.0168 3.2075 1.2060 5.2090 0.0017
  SF 1.00312 0.90378 1.11339 0.4932 0.9528 −2.0474 3.9529 0.5334
  RF 1.07206 0.96858 1.18660 0.1790 2.2751 −0.8554 5.4055 0.1542
  EF 1.13356 1.02036 1.25931 0.0196 2.3352 −0.2060 4.8763 0.0717
  CF 1.14062 1.03104 1.26184 0.0107 3.6824 1.5497 5.8152 0.0007
  FA 0.97062 0.88076 1.06965 0.5472 0.4928 −2.0393 3.0249 0.7027
  NV 1.03299 0.90587 1.17796 0.6279 2.0823 0.2119 3.9527 0.0291
  PA 0.84858 0.75492 0.95386 0.0060 −4.1552 −6.7318 −1.5786 0.0016
  DY 0.90265 0.83349 0.97755 0.0118 −6.9802 −9.8067 −4.1538 <.0001
  SL 1.06142 0.96736 1.16463 0.2078 −0.5849 −3.4526 2.2829 0.6892
  AP 1.14413 1.04285 1.25524 0.0044 7.7375 4.3808 11.0943 <.0001
  CO 0.94016 0.85740 1.03090 0.1892 −9.3181 −11.9276 −6.7085 <.0001
  DI 1.11676 0.99977 1.24744 0.0505 15.0773 12.5221 17.6324 <.0001
  FI 1.06304 0.94126 1.20057 0.3245 −3.9678 −5.8688 −2.0668 <.0001
SOCCAR QL 1.05911 0.94600 1.18576 0.3186 −0.3363 −3.2927 2.6201 0.8234
(N = 130) PF 1.00632 0.88085 1.14967 0.5260 −0.7855 −3.5393 1.9684 0.5758
  SF 1.07805 0.94331 1.23204 0.2696 −0.1569 −3.8385 3.5246 0.9333
  RF 0.92530 0.81065 1.05617 0.2497 −1.2639 −5.1956 2.6679 0.5283
  EF 0.86964 0.74753 1.01171 0.0704 −0.4552 −3.7208 2.8104 0.7845
  CF 1.21469 1.04469 1.41237 0.0115 2.8249 0.2230 5.4268 0.0334
  FA 1.09003 0.96258 1.23436 0.1740 −3.2001 −6.5586 0.1585 0.0618
  NV 0.96687 0.81577 1.14595 0.4073 1.1136 −1.6169 3.8441 0.4237
  PA 0.93405 0.81386 1.07199 0.3313 −3.3510 −6.7785 0.07654 0.0553
  DY 0.90277 0.81740 0.99707 0.0436 −2.0557 −5.5569 1.4456 0.2495
  SL 1.07573 0.95694 1.20927 0.2211 −0.8873 −4.4778 2.7033 0.6278
  AP 0.94817 0.83543 1.07613 0.4095 −0.2265 −4.0527 3.5997 0.9075
  CO 1.10100 0.95927 1.26368 0.1709 −0.8742 −4.4752 2.7267 0.6339
  DI 0.84506 0.68652 1.04021 0.1121 −0.4002 −2.8583 2.0580 0.7494
  FI 1.10633 0.94859 1.29029 0.1977 1.1951 −2.1001 4.4903 0.4768
Study 10 QL 0.94126 0.84476 1.05135 0.3912 −1.6241 −4.1816 1.8922 0.6124
(N = 241) PF 1.00563 0.89071 1.13537 0.9276 2.8207 −1.9594 7.6007 0.2467
  SF 1.00006 0.88002 1.13647 0.9993 4.0507 −0.9736 9.0750 0.1139
  RF 1.28860 1.08877 1.50121 0.0084 13.0540 0.3211 25.7870 0.0445
  EF 1.07878 0.93850 1.24003 0.2156 −2.8502 −7.4563 1.7558 0.2248
  CF 1.14441 0.96173 1.29133 0.1494 5.6888 2.0359 9.3417 0.0023
  FA 0.87034 0.77408 0.97858 0.0203 −2.0359 −6.1599 2.0882 0.3327
  NV 1.10180 0.94137 1.28957 0.2269 0.7394 −2.9807 4.4594 0.6965
  PA 0.81452 0.70091 0.94655 0.0075 −0.9057 −5.0882 3.2768 0.6708
  DY 0.90282 0.82439 0.98871 0.0275 −6.8389 −11.3035 −2.3743 0.0027
  SL 0.95514 0.85447 1.06767 0.4188 −0.3213 −5.8080 5.1655 0.9085
  AP 1.08583 0.95447 1.23526 0.2104 2.2718 −2.6561 7.1997 0.3657
  CO 0.86569 0.75412 0.99376 0.0405 −2.6788 −7.7010 2.3433 0.2953
  DI 0.92437 0.77487 1.10271 0.3818 −3.4211 −6.4418 −0.4004 0.0265
  FI 1.06566 0.82875 1.27688 0.3624 2.1354 −2.1141 6.5714 0.3252
Study 11 QL 0.95236 0.89286 1.09135 0.5552 −2.3613 −5.1511 2.9822 0.7334
(N = 422) PF 0.93089 0.84991 1.01958 0.1229 −2.7725 −6.0805 0.5356 0.1003
  SF 0.96121 0.87398 1.05714 0.4147 −3.3172 −6.9318 0.2974 0.0720
  RF 1.08853 0.94125 1.23477 0.3324 −7.1287 −14.3603 0.1028 0.0533
  EF 0.97549 0.88043 1.08081 0.6350 −4.8538 −8.0029 −1.7047 0.0026
  CF 0.95256 0.85588 1.06016 0.3731 −0.6141 −3.1705 1.9422 0.6374
  FA 1.10834 1.00731 1.21950 0.0349 3.3375 0.2209 6.4541 0.0359
  NV 1.29384 1.15215 1.42351 <0.0001 5.4863 3.3832 7.5895 <.0001
  PA 1.00011 0.89283 1.12028 0.9985 0.9084 −1.9043 3.7210 0.5264
  DY 1.04262 0.96229 1.12965 0.3073 −1.6110 −5.1973 1.9754 0.3783
  SL 1.02938 0.94433 1.12209 0.5102 −4.0055 −7.6480 −0.3629 0.0312
  AP 1.04393 0.94403 1.15440 0.4019 4.6020 0.7884 8.4157 0.0181
  CO 1.06104 0.95671 1.17675 0.1117 2.6096 −0.7817 6.0008 0.1314
  DI 1.13002 0.95487 1.33729 0.1547 0.9181 −0.9858 2.8219 0.3442
  FI 1.08816 0.92995 1.22408 0.4498 1.9684 −2.0451 5.6714 0.5022
Study 12 QL 0.96311 0.89103 1.04421 0.5034 −0.8545 −2.8925 1.19985 0.3214
(N = 724) PF 1.00156 0.93624 1.07143 0.9639 −0.01443 −2.9124 2.8835 0.9922
  SF 0.93058 0.87602 0.98855 0.0196 0.2535 −2.2932 2.8002 0.8453
  RF 0.94478 0.89925 0.99755 0.0536 −6.3209 −11.8670 −0.7747 0.0255
  EF 0.96366 0.90173 1.02985 0.2747 −4.0689 −6.3917 −1.7461 0.0006
  CF 0.96082 0.89968 1.02612 0.1334 −1.2498 −3.1386 0.6391 0.1946
  FA 0.99963 0.94240 1.06033 0.4901 −0.6901 −2.8719 1.4917 0.5352
  NV 0.95818 0.88480 1.03765 0.2933 5.4863 3.3832 7.5895 <.0001
  PA 0.96961 0.89701 1.04809 0.4370 0.9084 −1.9043 3.7210 0.5264
  DY 1.03922 0.98989 1.09102 0.1210 3.9991 1.3876 6.6105 0.0027
  SL 0.90162 0.84630 0.96055 0.0014 −15.5470 −18.0563 −13.0378 <.0001
  AP 1.06787 0.99510 1.14597 0.0682 −2.2811 −4.6592 0.09705 0.0601
  CO 1.16848 1.09944 1.24186 <.0001 2.6096 −0.7817 6.0008 0.1314
  DI 1.05255 0.95709 1.15754 0.2909 −2.3379 −3.8004 −0.8754 0.0017
  FI 1.01842 0.92606 1.12000 0.7064 1.6197 −2.5375 5.7768 0.4445
Study 14 QL 0.96684 0.91236 1.05549 0.2123 −1.3897 −3.2450 0.9808 0.0983
(N = 722) PF 0.95134 0.89346 1.01298 0.1193 −1.7843 −3.6934 0.1248 0.0670
  SF 1.01050 0.94612 1.07926 0.7557 0.8731 −1.1044 2.8507 0.3867
  RF 0.92540 0.89452 0.99358 0.0412 −6.0800 −10.1493 −2.0107 0.0034
  EF 0.89881 0.83696 0.96523 0.0034 −1.9677 −3.5103 −0.4251 0.0124
  CF 1.04520 0.96868 1.12776 0.2543 −0.07931 −1.4565 1.2978 0.9101
  FA 1.03864 0.97432 1.10720 0.2450 1.1338 −0.5280 2.7955 0.1811
  NV 0.92440 0.84363 1.01291 0.0920 −1.7769 −3.0100 −0.5437 0.0048
  PA 1.07278 0.98702 1.16600 0.0984 −0.5521 −2.2252 1.1210 0.5176
  DY 1.02074 0.96756 1.07683 0.4520 1.3292 −0.5879 3.2464 0.1741
  SL 0.96340 0.89862 1.03286 0.2937 −8.0830 −10.1365 −6.0295 <.0001
  AP 0.98802 0.91442 1.06755 0.7602 −3.8491 −5.8767 −1.8216 0.0002
  CO 1.07744 1.00746 1.15228 0.0295 10.9195 8.8799 12.9590 <.0001
  DI 1.05388 0.95077 1.16817 0.3177 −1.6529 −2.8431 −0.4628 0.0065
  FI 0.99605 0.89553 1.10785 0.9418 2.3020 −2.4081 7.0122 0.3375
  1. Key: 5 functional scales: PF physical function, RF role function, EF emotional function, CF cognitive function, and SF social functioning; 9 ‘symptom’ scales: FA fatigue, NV nausea & vomiting, PA pain, DY dyspnoea, IN insomnia, AL appetite loss, CO constipation, DI diarrhoea, FI financial problems; and QL a global health status score
  2. Positive differences on the functional scale are improvements in quality of life with the experimental arm
  3. Positive differences on the symptom scale suggests a worsening in quality of life with the experimental arm