Odds ratio | Mean Difference (MD) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Study | QLQ-C30 | Odds Ratio | Lower 95 % CI | Upper 95 % CI | P-value | Difference | Lower 95 % CI | Upper 95 % CI | P-value |
TOPICAL | QL | 0.99840 | 0.92173 | 1.08145 | 0.4687 | 0.6433 | −1.4409 | 2.7274 | 0.5450 |
(N = 670) | PF | 1.10396 | 1.01803 | 1.19714 | 0.0168 | 3.2075 | 1.2060 | 5.2090 | 0.0017 |
SF | 1.00312 | 0.90378 | 1.11339 | 0.4932 | 0.9528 | −2.0474 | 3.9529 | 0.5334 | |
RF | 1.07206 | 0.96858 | 1.18660 | 0.1790 | 2.2751 | −0.8554 | 5.4055 | 0.1542 | |
EF | 1.13356 | 1.02036 | 1.25931 | 0.0196 | 2.3352 | −0.2060 | 4.8763 | 0.0717 | |
CF | 1.14062 | 1.03104 | 1.26184 | 0.0107 | 3.6824 | 1.5497 | 5.8152 | 0.0007 | |
FA | 0.97062 | 0.88076 | 1.06965 | 0.5472 | 0.4928 | −2.0393 | 3.0249 | 0.7027 | |
NV | 1.03299 | 0.90587 | 1.17796 | 0.6279 | 2.0823 | 0.2119 | 3.9527 | 0.0291 | |
PA | 0.84858 | 0.75492 | 0.95386 | 0.0060 | −4.1552 | −6.7318 | −1.5786 | 0.0016 | |
DY | 0.90265 | 0.83349 | 0.97755 | 0.0118 | −6.9802 | −9.8067 | −4.1538 | <.0001 | |
SL | 1.06142 | 0.96736 | 1.16463 | 0.2078 | −0.5849 | −3.4526 | 2.2829 | 0.6892 | |
AP | 1.14413 | 1.04285 | 1.25524 | 0.0044 | 7.7375 | 4.3808 | 11.0943 | <.0001 | |
CO | 0.94016 | 0.85740 | 1.03090 | 0.1892 | −9.3181 | −11.9276 | −6.7085 | <.0001 | |
DI | 1.11676 | 0.99977 | 1.24744 | 0.0505 | 15.0773 | 12.5221 | 17.6324 | <.0001 | |
FI | 1.06304 | 0.94126 | 1.20057 | 0.3245 | −3.9678 | −5.8688 | −2.0668 | <.0001 | |
SOCCAR | QL | 1.05911 | 0.94600 | 1.18576 | 0.3186 | −0.3363 | −3.2927 | 2.6201 | 0.8234 |
(N = 130) | PF | 1.00632 | 0.88085 | 1.14967 | 0.5260 | −0.7855 | −3.5393 | 1.9684 | 0.5758 |
SF | 1.07805 | 0.94331 | 1.23204 | 0.2696 | −0.1569 | −3.8385 | 3.5246 | 0.9333 | |
RF | 0.92530 | 0.81065 | 1.05617 | 0.2497 | −1.2639 | −5.1956 | 2.6679 | 0.5283 | |
EF | 0.86964 | 0.74753 | 1.01171 | 0.0704 | −0.4552 | −3.7208 | 2.8104 | 0.7845 | |
CF | 1.21469 | 1.04469 | 1.41237 | 0.0115 | 2.8249 | 0.2230 | 5.4268 | 0.0334 | |
FA | 1.09003 | 0.96258 | 1.23436 | 0.1740 | −3.2001 | −6.5586 | 0.1585 | 0.0618 | |
NV | 0.96687 | 0.81577 | 1.14595 | 0.4073 | 1.1136 | −1.6169 | 3.8441 | 0.4237 | |
PA | 0.93405 | 0.81386 | 1.07199 | 0.3313 | −3.3510 | −6.7785 | 0.07654 | 0.0553 | |
DY | 0.90277 | 0.81740 | 0.99707 | 0.0436 | −2.0557 | −5.5569 | 1.4456 | 0.2495 | |
SL | 1.07573 | 0.95694 | 1.20927 | 0.2211 | −0.8873 | −4.4778 | 2.7033 | 0.6278 | |
AP | 0.94817 | 0.83543 | 1.07613 | 0.4095 | −0.2265 | −4.0527 | 3.5997 | 0.9075 | |
CO | 1.10100 | 0.95927 | 1.26368 | 0.1709 | −0.8742 | −4.4752 | 2.7267 | 0.6339 | |
DI | 0.84506 | 0.68652 | 1.04021 | 0.1121 | −0.4002 | −2.8583 | 2.0580 | 0.7494 | |
FI | 1.10633 | 0.94859 | 1.29029 | 0.1977 | 1.1951 | −2.1001 | 4.4903 | 0.4768 | |
Study 10 | QL | 0.94126 | 0.84476 | 1.05135 | 0.3912 | −1.6241 | −4.1816 | 1.8922 | 0.6124 |
(N = 241) | PF | 1.00563 | 0.89071 | 1.13537 | 0.9276 | 2.8207 | −1.9594 | 7.6007 | 0.2467 |
SF | 1.00006 | 0.88002 | 1.13647 | 0.9993 | 4.0507 | −0.9736 | 9.0750 | 0.1139 | |
RF | 1.28860 | 1.08877 | 1.50121 | 0.0084 | 13.0540 | 0.3211 | 25.7870 | 0.0445 | |
EF | 1.07878 | 0.93850 | 1.24003 | 0.2156 | −2.8502 | −7.4563 | 1.7558 | 0.2248 | |
CF | 1.14441 | 0.96173 | 1.29133 | 0.1494 | 5.6888 | 2.0359 | 9.3417 | 0.0023 | |
FA | 0.87034 | 0.77408 | 0.97858 | 0.0203 | −2.0359 | −6.1599 | 2.0882 | 0.3327 | |
NV | 1.10180 | 0.94137 | 1.28957 | 0.2269 | 0.7394 | −2.9807 | 4.4594 | 0.6965 | |
PA | 0.81452 | 0.70091 | 0.94655 | 0.0075 | −0.9057 | −5.0882 | 3.2768 | 0.6708 | |
DY | 0.90282 | 0.82439 | 0.98871 | 0.0275 | −6.8389 | −11.3035 | −2.3743 | 0.0027 | |
SL | 0.95514 | 0.85447 | 1.06767 | 0.4188 | −0.3213 | −5.8080 | 5.1655 | 0.9085 | |
AP | 1.08583 | 0.95447 | 1.23526 | 0.2104 | 2.2718 | −2.6561 | 7.1997 | 0.3657 | |
CO | 0.86569 | 0.75412 | 0.99376 | 0.0405 | −2.6788 | −7.7010 | 2.3433 | 0.2953 | |
DI | 0.92437 | 0.77487 | 1.10271 | 0.3818 | −3.4211 | −6.4418 | −0.4004 | 0.0265 | |
FI | 1.06566 | 0.82875 | 1.27688 | 0.3624 | 2.1354 | −2.1141 | 6.5714 | 0.3252 | |
Study 11 | QL | 0.95236 | 0.89286 | 1.09135 | 0.5552 | −2.3613 | −5.1511 | 2.9822 | 0.7334 |
(N = 422) | PF | 0.93089 | 0.84991 | 1.01958 | 0.1229 | −2.7725 | −6.0805 | 0.5356 | 0.1003 |
SF | 0.96121 | 0.87398 | 1.05714 | 0.4147 | −3.3172 | −6.9318 | 0.2974 | 0.0720 | |
RF | 1.08853 | 0.94125 | 1.23477 | 0.3324 | −7.1287 | −14.3603 | 0.1028 | 0.0533 | |
EF | 0.97549 | 0.88043 | 1.08081 | 0.6350 | −4.8538 | −8.0029 | −1.7047 | 0.0026 | |
CF | 0.95256 | 0.85588 | 1.06016 | 0.3731 | −0.6141 | −3.1705 | 1.9422 | 0.6374 | |
FA | 1.10834 | 1.00731 | 1.21950 | 0.0349 | 3.3375 | 0.2209 | 6.4541 | 0.0359 | |
NV | 1.29384 | 1.15215 | 1.42351 | <0.0001 | 5.4863 | 3.3832 | 7.5895 | <.0001 | |
PA | 1.00011 | 0.89283 | 1.12028 | 0.9985 | 0.9084 | −1.9043 | 3.7210 | 0.5264 | |
DY | 1.04262 | 0.96229 | 1.12965 | 0.3073 | −1.6110 | −5.1973 | 1.9754 | 0.3783 | |
SL | 1.02938 | 0.94433 | 1.12209 | 0.5102 | −4.0055 | −7.6480 | −0.3629 | 0.0312 | |
AP | 1.04393 | 0.94403 | 1.15440 | 0.4019 | 4.6020 | 0.7884 | 8.4157 | 0.0181 | |
CO | 1.06104 | 0.95671 | 1.17675 | 0.1117 | 2.6096 | −0.7817 | 6.0008 | 0.1314 | |
DI | 1.13002 | 0.95487 | 1.33729 | 0.1547 | 0.9181 | −0.9858 | 2.8219 | 0.3442 | |
FI | 1.08816 | 0.92995 | 1.22408 | 0.4498 | 1.9684 | −2.0451 | 5.6714 | 0.5022 | |
Study 12 | QL | 0.96311 | 0.89103 | 1.04421 | 0.5034 | −0.8545 | −2.8925 | 1.19985 | 0.3214 |
(N = 724) | PF | 1.00156 | 0.93624 | 1.07143 | 0.9639 | −0.01443 | −2.9124 | 2.8835 | 0.9922 |
SF | 0.93058 | 0.87602 | 0.98855 | 0.0196 | 0.2535 | −2.2932 | 2.8002 | 0.8453 | |
RF | 0.94478 | 0.89925 | 0.99755 | 0.0536 | −6.3209 | −11.8670 | −0.7747 | 0.0255 | |
EF | 0.96366 | 0.90173 | 1.02985 | 0.2747 | −4.0689 | −6.3917 | −1.7461 | 0.0006 | |
CF | 0.96082 | 0.89968 | 1.02612 | 0.1334 | −1.2498 | −3.1386 | 0.6391 | 0.1946 | |
FA | 0.99963 | 0.94240 | 1.06033 | 0.4901 | −0.6901 | −2.8719 | 1.4917 | 0.5352 | |
NV | 0.95818 | 0.88480 | 1.03765 | 0.2933 | 5.4863 | 3.3832 | 7.5895 | <.0001 | |
PA | 0.96961 | 0.89701 | 1.04809 | 0.4370 | 0.9084 | −1.9043 | 3.7210 | 0.5264 | |
DY | 1.03922 | 0.98989 | 1.09102 | 0.1210 | 3.9991 | 1.3876 | 6.6105 | 0.0027 | |
SL | 0.90162 | 0.84630 | 0.96055 | 0.0014 | −15.5470 | −18.0563 | −13.0378 | <.0001 | |
AP | 1.06787 | 0.99510 | 1.14597 | 0.0682 | −2.2811 | −4.6592 | 0.09705 | 0.0601 | |
CO | 1.16848 | 1.09944 | 1.24186 | <.0001 | 2.6096 | −0.7817 | 6.0008 | 0.1314 | |
DI | 1.05255 | 0.95709 | 1.15754 | 0.2909 | −2.3379 | −3.8004 | −0.8754 | 0.0017 | |
FI | 1.01842 | 0.92606 | 1.12000 | 0.7064 | 1.6197 | −2.5375 | 5.7768 | 0.4445 | |
Study 14 | QL | 0.96684 | 0.91236 | 1.05549 | 0.2123 | −1.3897 | −3.2450 | 0.9808 | 0.0983 |
(N = 722) | PF | 0.95134 | 0.89346 | 1.01298 | 0.1193 | −1.7843 | −3.6934 | 0.1248 | 0.0670 |
SF | 1.01050 | 0.94612 | 1.07926 | 0.7557 | 0.8731 | −1.1044 | 2.8507 | 0.3867 | |
RF | 0.92540 | 0.89452 | 0.99358 | 0.0412 | −6.0800 | −10.1493 | −2.0107 | 0.0034 | |
EF | 0.89881 | 0.83696 | 0.96523 | 0.0034 | −1.9677 | −3.5103 | −0.4251 | 0.0124 | |
CF | 1.04520 | 0.96868 | 1.12776 | 0.2543 | −0.07931 | −1.4565 | 1.2978 | 0.9101 | |
FA | 1.03864 | 0.97432 | 1.10720 | 0.2450 | 1.1338 | −0.5280 | 2.7955 | 0.1811 | |
NV | 0.92440 | 0.84363 | 1.01291 | 0.0920 | −1.7769 | −3.0100 | −0.5437 | 0.0048 | |
PA | 1.07278 | 0.98702 | 1.16600 | 0.0984 | −0.5521 | −2.2252 | 1.1210 | 0.5176 | |
DY | 1.02074 | 0.96756 | 1.07683 | 0.4520 | 1.3292 | −0.5879 | 3.2464 | 0.1741 | |
SL | 0.96340 | 0.89862 | 1.03286 | 0.2937 | −8.0830 | −10.1365 | −6.0295 | <.0001 | |
AP | 0.98802 | 0.91442 | 1.06755 | 0.7602 | −3.8491 | −5.8767 | −1.8216 | 0.0002 | |
CO | 1.07744 | 1.00746 | 1.15228 | 0.0295 | 10.9195 | 8.8799 | 12.9590 | <.0001 | |
DI | 1.05388 | 0.95077 | 1.16817 | 0.3177 | −1.6529 | −2.8431 | −0.4628 | 0.0065 | |
FI | 0.99605 | 0.89553 | 1.10785 | 0.9418 | 2.3020 | −2.4081 | 7.0122 | 0.3375 |