A meta-analysis of four randomized clinical trials to confirm the reliability and responsiveness of the Shortness of Breath with Daily Activities (SOBDA) questionnaire in chronic obstructive pulmonary disease

Table 2 Thresholds calculated using change from baseline to SOBDA prior week score

	TDI^a (Day 168)				SGRQ^b (Day 168)			CAT^c (Day 168)
	No change or worse	Minor improvement	Moderate improvement	Major improvement	No change or worse	Minor improvement	Moderate improvement	No change or worse	Minor improvement	Major improvement
n	1375	1108	635	215	1331	437	1345	510	159	503
Mean change from baseline to SOBDA prior week score (SD)	−0.09 (0.515)	−0.22 (0.530)	−0.30 (0.549)	−0.49 (0.574)	−0.02 (0.493)	−0.17 (0.500)	−0.37 (0.547)	−0.10 (0.506)	−0.16 (0.515)	−0.38 (0.608)

CAT COPD Assessment Test, COPD chronic obstructive pulmonary disease, SD standard deviation, SGRQ St George’s Respiratory Questionnaire, SOBDA Shortness of Breath with Daily Activities, TDI Transitional Dyspnea Index
^aNo change or worse is defined as a score of 0 or less, minor improvement is defined as a score of 1–3, moderate improvement is defined as a score of 4–6 and major improvement is defined as a score of 7–9
^bNo change or worse is defined as a change from baseline of > −4 units, minor improvement is defined as a change from baseline of > −8 to ≤ −4 units and moderate improvement is defined as a change from baseline of ≤ −8 units
^cNo change or worse is defined as a change from baseline of > −2 units, minor improvement is defined as a change from baseline of > −4 to ≤ −2 units, major improvement is defined as a change from baseline of ≤ −4 units; for studies DB2113360 and DB2113374

ISSN: 1477-7525