Skip to main content

Table 2 Content analysis and confirmatory factor analyses of the individual ThyPRO scales

From: Confirmatory factor analysis of the thyroid-related quality of life questionnaire ThyPRO

Scale and item

Possible misfit from content analysis

Initial unidimensional modela

Item #

Abbreviated item content

Unrelated content

Local dependence

Factor loading

Indication of local dependenceb

Indication of item misfitc

Goiter Symptoms

  

CFI=0.95 RMSEA=0.16(0.15-0.16)

2a

Sense of fullness in neck

  

0.87

MI: LD with 2b

 

2b

Visible swelling on neck

  

0.60

MI and RC: LD with 2a

Low loading

2c

Pressure in throat

  

0.90

RC: LD with 2g

 

2d

Pain in front of neck

 

With 2e

0.71

  

2e

Throat pain felt in ears

*

With 2d

0.60

 

Low loading and low IC

2f

Lump in throat

  

0.85

  

2g

Clear throat often

*

 

0.69

MI: LD with 2l, RC: LD w. 2c

2h

Discomfort swallowing

 

With 2i

0.94

MI: LD with 2i

 

2i

Difficulty swallowing

 

With 2h

0.92

MI: LD with 2h

 

2j

Sense of suffocating

  

0.73

  

2l

Hoarseness

*

 

0.56

MI: LD with 2g

Low loading

Hyperthyroid Symptoms

  

CFI=0.80 RMSEA=0.18(0.17-0.19)

2m

Trembling hands

  

0.60

  

2n

Increased sweating

 

With 2o, 2p, 2q

0.71

MI: LD with 2q

 

2o

Palpitations

 

With 2n, 2p

0.69

  

2p

Shortness of breath

 

With 2n, 2o

0.64

  

2q

Sensitive to heat

 

With 2n

0.70

MI: LD with 2n

 

2s

Increased appetite

  

0.54

  

2t

Loose stools

 

With 2u

0.75

 

Low IC and large neg. RCs

2u

Upset stomach

 

With 2t

0.80

  

Hypothyroid Symptoms

  

CFI=0.98 RMSEA=0.10(0.06-0.14)

2r

Sensitive to cold

  

0.56

  

2ff

Swollen hands or feet

  

0.62

  

2gg

Dry skin

 

With 2hh

0.86

RC: LD with 2hh

 

2hh

Itching skin

 

With 2gg

0.63

RC: LD with 2gg

 

Eye Symptoms

  

CFI=0.94 RMSEA=0.11(0.09-0.11)

2w

Watery eyes

 

With 2y, cc, dd

0.62

MI and RC: LD with 2x

 

2x

Bags under the eyes

  

0.59

MI and RC: LD with 2w

 

2y

Grittiness in eyes

 

With 2w, 2cc, 2dd

0.74

  

2z

Reduced sight

*

 

0.68

  

2aa

Pressure in eyes

 

With 2cc

0.87

MI: LD with 2cc

 

2bb

Double vision

*

 

0.70

  

2cc

Pain in eyes

 

With 2w, y, dd, aa

0.86

MI: LD with 2aa

 

2dd

Sensitive to light

 

With 2w, y, cc

0.70

  

Tiredness

  

CFI=0.99 RMSEA=0.28(0.26-0.28)

3a

Been tired

  

0.90

MI: LD with 3b

 

3b

Been exhausted

  

0.93

MI: LD with 3a

 

3c

Difficult get motivated

  

0.89

  

3d

Felt worn out

  

0.91

  

4a

Full of life

 

With 4b, 4c

0.93

MI and RC: LD with 4b, 4c

 

4b

Energetic

 

With 4a, 4c

0.98

MI and RC: LD with 4a, 4c

 

4c

Able to cope with life

 

With 4a, 4b

0.95

MI and RC: LD with 4a, 4b

 

Cognitive Complaints

  

CFI=0.99 RMSEA=0.13(0.11-0.15)

5a

Problems remembering

 

With 5c

0.87

RC: LD with 5d

 

5b

Slow or unclear thinking

 

With 5f

0.94

  

5c

Difficulty finding words

 

With 5a

0.85

  

5d

Been confused

*

 

0.85

RC: LD with 5a

 

5e

Difficulty learning

  

0.92

MI: LD with 5f

 

5f

Difficulty concentrating

 

With 5b

0.91

MI: LD with 5e

 

Anxiety

  

CFI=0.97 RMSEA=0.16(0.14-0.18)

6a

Nervous

  

0.90

MI: LD with 6b

 

6b

Afraid or anxious

  

0.90

MI: LD with 6a

 

6c

Felt tension

  

0.88

  

6d

Afraid being seriously ill

*

 

0.70

 

Low loading, neg. RC's

6e

Uneasy

 

With 6f

0.92

MI: LD with 6f

 

6f

Restless

 

With 6e

0.80

MI: LD with 6e

 

Depressivity

  

CFI=0.96 RMSEA=0.24(0.23-0.26)

7a

Sad

  

0.95

  

7b

Depressed

 

With 7c

0.92

  

7c

Discouraged

 

With 7b

0.94

  

7e

Crying easily

*

 

0.79

MI: LD with 7f

 

7f

Unhappy

 

With 7g

0.92

MI: LD with 7e

 

7g

Happy

 

With 7i, 7f

0.76

MI: LD with 7i

 

7i

Self-confident

*

With 7g

0.74

MI: LD with 7g

 

Emotional Susceptibility

  

CFI=0.92 RMSEA=0.24(0.23-0.25)

8a

Difficulty coping

  

0.80

  

8b

Not like yourself

  

0.80

  

8c

Easily stressed

  

0.81

MI: LD with 8i

 

8d

Mood swings

  

0.88

  

8e

Irritable

 

With 8g

0.89

 

Large neg. RC

8f

Frustrated

  

0.91

 

MI: LD with many other items

8g

Angry

 

With 8e

0.80

 

MI: LD with many other items

8h

Felt in control

 

With 8i

0.87

 

MI: LD with many, large neg. RC's

8i

Felt in balance

 

With 8h

0.91

MI: LD with 8i, 8c

 

Impaired Social Life

  

CFI=0.99 RMSEA=0.08(0.05-0.13)

10a

Difficult with people

  

0.90

  

10b

A burden to people

  

0.89

  

10c

Conflicts with people

  

0.80

  

10e

Others lack understanding

*

 

0.71

 

Low loading, neg. RC's

Impaired Daily Life

  

CFI=0.99 RMSEA=0.10(0.08-0.12)

11a

Difficult manage life

  

0.94

  

11b

Limit leisure activities

 

With 11f

0.95

MI: LD with 11f

 

11c

Difficult participate in life

  

0.96

  

11d

Difficult getting around

*

 

0.84

MI: LD with 11e

 

11e

Everything takes longer

*

 

0.85

MI: LD with 11d

 

11f

Difficulty managing job

 

With 11b

0.88

MI: LD with 11b

 

Cosmetic Concern

  

CFI=0.98 RMSEA=0.10(0.08-0.12)

13a

Disease affect appearance

 

With 13b

0.83

MI: LD with 13b

 

13b

Unsatisfied appearance

 

With 13a

0.98

MI: LD with 13a

 

13c

Camouflage visible signs

  

0.79

  

13d

Other people looking

  

0.83

  

13e

Influence on clothes worn

  

0.79

  

13g

Felt too fat

*

 

0.65

 

Low loading

  1. aCFI: Comparative fit index, RMSEA: Root mean square error of approximation with 90% confidence interval.
  2. bMI: Modification indices, LD: local dependence, RC: model residual correlation.
  3. cIC: Model inter-item correlation.
  4. Left part of the table presents the results of the initial content analyses. The results of the initial unidimensional confirmatory factor analyses are presented in the right part of the table: overall goodness-of-fit, factor loadings as well as the indices of possible local dependency and item misfit which lead to remodeling in next steps of the analyses.
Back to article page

Health and Quality of Life Outcomes

ISSN: 1477-7525

Contact us