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Table 5 Sensitivity analysis of utility estimates by GOLD 2013 classification

From: Generic utilities in chronic obstructive pulmonary disease patients stratified according to different staging systems

 

Base case

Sensitivity analyses

CAT and mMRC

CAT

mMRC

p-value3

GOLD 20132

A

   

0.058

N (%)

28 (8.1%)

33 (9.5%)

68 (19.7%)

Mean (SD)

0.96 (0.07)

0.94 (0.10)

0.91 (0.09)

Median (IQR)

1.00 (0.09)

1.00 (0.09)

0.91 (0.16)

B

   

0.04

N (%)

66 (19.1%)

61 (17.6%)

26 (7.5%)

Mean (SD)

0.80 (0.22)

0.80 (0.23)

0.68 (0.30)

Median (IQR)

0.87 (0.13)

0.87 (0.13)

0.78 (0.35)

C

   

0.2

N (%)

30 (8.7%)

41 (11.8%)

87 (25.1%)

Mean (SD)

0.88 (0.25)

0.86 (0.24)

0.84 (0.22)

Median (IQR)

1.00 (0.16)

0.91 (0.18)

0.89 (0.22)

D

   

0.1

N (%)

222 (64.2%)

211 (61.0%)

165 (47.7%)

Mean (SD)

0.66 (0.31)

0.65 (0.31)

0.61 (0.32)

Median (IQR)

0.74 (0.29)

0.74 (0.31)

0.71 (0.31)

 

p value1

<0.001

<0.001

<0.001

 
  1. 1Kruskal-Wallis test and Mann-Whitney U test for post-hoc comparisons (Bonferroni-adjusted).
  2. Base case and sensitivity analysis (CAT): all pairwise comparisons were significant except between A and C; Sensitivity analysis (mMRC): all pairwise comparisons were significant except between A and C, and between B and D.
  3. 2A: low risk, few symptoms; B: low risk, many symptoms; C: high risk, few symptoms; D: high risk, many symptoms.
  4. 3Comparison of utilities according to classification by CAT or mMRC. Mann-Whitney U test (without alpha-adjustment).
  5. SD = standard deviation, IQR = interquartile range, CAT = COPD Assessment Test, mMRC = modified Medical Research Council.
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Health and Quality of Life Outcomes

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