Table 6 Responsiveness (MSSS-88, NRS)
MSSS-88 Subscale | Patients treated with cannabinoid oromucosal spray (n = 24) | Patients not treated with cannabinoid oromucosal spray (n = 42) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | n | Baseline | Follow-Up | Change baseline to Follow-up | n | Baseline | Follow-Up | Change baseline to Follow-up | ||||
|  |  | M ± SD | M ± SD | Mean Difference (SD) | p- value+ | Cohen d |  | M ± SD | M ± SD | Mean Difference (SD) | p- value+ | Cohen d |
Muscle Stiffness | 22 | 76.55 ± 17.58 | 70.74 ± 14.25 | -5.81 (15.08) | 0.0852 | 0.39 | 42 | 48.74 ± 24.60 | 48.45 ± 19.88 | -0.28 (16.92) | 0.9143 | 0.02 |
Pain and Discomfort | 21 | 56.97 ± 27.25 | 46.80 ± 22.74 | -10.16 (19.97) | 0.0302 | 0.51 | 42 | 34.87 ± 24.36 | 35.98 ± 20.84 | 1.11 (17.80) | 0.6873 | 0.06 |
Muscle Spasms | 23 | 56.48 ± 18.21 | 41.69 ± 14.04 | -14.79 (22.45) | 0.0045 | 0.66 | 41 | 32.20 ± 21.47 | 29.97 ± 17.11 | -2.23 (17.49) | 0.4189 | 0.13 |
Activities of Daily Living | 24 | 67.30 ± 26.55 | 66.49 ± 26.15 | -0.80 (12.65) | 0.7581 | 0.06 | 38 | 34.99 ± 30.53 | 34.94 ± 26.98 | -0.06 (17.05) | 0.9840 | 0.00 |
Walking | 15 | 72.44 ± 21.10 | 68.67 ± 21.63 | -3.78 (20.47) | 0.4864 | 0.18 | 38 | 60.10 ± 27.02) | 59.47 ± 28.45 | -0.62 (21.07) | 0.8562 | 0.03 |
Body Movements | 22 | 74.10 ± 22.20 | 66.36 ± 22.23 | -7.74 (17.01) | 0.0446 | 0.46 | 41 | 49.31 ± 28.93 | 45.97 ± 24.53 | -3.33 (20.39) | 0.3014 | 0.16 |
Emotional Health | 22 | 43.50 ± 24.11 | 32.05 ± 23.84 | -11.45 (22.30) | 0.0253 | 0.51 | 42 | 30.43 ± 25.26 | 28.33 ± 24.92 | -2.11 (19.49) | 0.4876 | 0.11 |
Social Functioning | 22 | 49.51 ± 28.48 | 41.72 ± 24.42 | -7.79 (18.97) | 0.0677 | 0.41 | 41 | 30.05 ± 25.27 | 29.81 ± 22.41 | -0.25 (23.15) | 0.9459 | 0.01 |
NRS spasticity | 24 | 6.71 ± 1.55 | 5.96 ± 1.71 | -0.75 (1.26) | 0.0078 | 0.60 | 41 | 3.98 ± 2.25 | 3.71 ± 2.11 | -0.27 (1.64) | 0.3022 | 0.16 |