Table 1 Summary of key issues and corresponding HQLO references

Development & interpretation of HRQoL outcomes

Bakas T et al., 2012 [2]; Johnston BC et al., 2013 [8]

Pediatric HRQoL measurement

Irwin DE et al., 2012 [10]; Rajmil L et al., 2013 [19]

Incorporation of HRQoL in economic evaluations

Jones C et al., 2012 [22]; Kim SH et al., 2012 [26]; Dakin H, 2013 [27]; Wilke S et al., 2012 [31]

Methodological issues and innovations in HRQoL measures

Measurement equivalence

Lix M et al., 2012 [42];

Selection bias

Hutchings A et al., 2012 [54]; Coste J et al., 2013 [55]

Evaluating change in health status

Wilson R et al., 2012 [58]; Turner N et al., 2013 [60]; Kuspinar A et al., 2013 [61]; Khadka J et al., 2012 [61]; Krabbe J et al., 2012 [63]