Table 1 Demographic and clinical data of the studied subjects (n = 48)
Feature | Patients assigned to therapy with omeprazole first (n = 23) | Patients assigned to therapy with the placebo first (n = 25) |
|---|---|---|
Age (years) | 58.3 (55.3-61.2) | 61.2 (58.1-62.2) |
Gender (males, n, %) | 19 (83%) | 18 (72%) |
Number of angina-like symptoms per week (median and range) | 10 (6-35) | 12 (6-30) |
Number of patients with angina-like symptom severity graded according to CCS classification | Class II-19 (83%) Class III-4 (17%) | Class II-17 (68%) Class III-8 (32%) |
Dyslipidemia | 21 (91%) | 24 (96%) |
Concentration of total cholesterol (mg/dl) | 198.3 (177-220) | 197.9 (182.2-213.5) |
Concentration of LDL cholesterol (mg/dl) | 118.5 (95.6-141.4) | 113.1 (103.2-123.0) |
Concentration of HDL cholesterol (mg/dl) | 52.6 (46.6-58.6) | 50.6 (42.5-58.6) |
Concentration of triglycerides (mg/dl) | 175.8 (125.6-225.9) | 176.9 (125-229) |
Hypertension | 14 (61%) | 11 (44%) |
Diabetes mellitus | 5 (22%) | 9 (36%) |
Smoking | 7 (30%) | 5 (20%) |
History of myocardial infarction | 13 (57%) | 17 (68%) |
History of PCI | 6 (26%) | 11 (44%) |
History of CABG | 3 (13%) | 4 (16%) |
Ejection fraction in echocardiography (%) | 54.5 (47.2-61.7) | 53.8 ± 8.4 |
Aspirin administration | 23 (100%) | 25 (100%) |
Beta-blocker administration | 19 (88%) | 25 (100%) |
Calcium-blocker administration | 7 (30%) | 6 (24%) |
ACEI administration | 20 (87%) | 19 (76%) |
Number of nitroglycerin tablets taken per week (median and range) | 3 (0-20) | 3 (0-15) |
Long-acting nitrate administration | 7 (30%) | 15 (60%)* |
Statin administration | 21 (94%) | 24 (96%) |
BMI (kg/m2) | 28.4 (26.8-30.0) | 28.1 (26.6-29.7) |
WHR | 0.94 (0.91-0.97) | 0.92 (0.89-0.92) |