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Table 2 Mean Improvement in PROs Corresponding to a 2-Point Improvement in Pain for Patients and Preselected Subgroups

From: Relationships between changes in pain severity and other patient-reported outcomes: an analysis in patients with posttraumatic peripheral neuropathic pain

  MEAN (95% CI) IMPROVEMENT IN PRO THAT CORRESPONDED TO A 2-POINT IMPROVEMENT IN PAIN
GROUP MOS-SS DISTURBANCE MOS-SS 9-ITEM SLEEP PROBLEMS INDEX SLEEP INTERFERENCE (NRS) HADS ANXIETY HADS DEPRESSION PII
All patients
(N = 254)
-11.87
(-14.83, -8.91)
-7.59
(-9.91, -5.27)
-1.64
(-1.86, -1.43)
-1.52
(-1.97, -1.07)
-1.23
(-1.58,-0.88)
-1.48
(-1.72, -1.25)
Subgroups       
30% responders
(n = 82)*
-11.57
(-19.17, -3.98)
-7.41
(-13.31, -1.50)
-1.54
(-2.05, -1.03)
-1.57
(-2.61, -0.53)
-1.39
(-2.13,-0.65)
-1.68
(-2.22, -1.14)
50% responders
(n = 48)*
-13.12
(-25.04, -1.19)
-8.37
(-18.07,1.32)
-1.70
(-2.70,-0.70)
-2.04
(-3.88, -0.21)
-1.25
(-2.50,0)
-2.21
(-3.13,-1.28)
Pregabalin-
treated patients
(n = 127)
-15.79
(-19.76, -11.83)
-9.85
(-13.14, -6.57)
-1.67
(-1.96, -1.38)
-1.64
(-2.25,-1.03)
-1.56
(-2.00,-1.12)
-1.71
(-2.05,-1.38)
Placebo-treated
patients (n = 127)
-7.09
(-11.51,-2.68)
-4.93
(-8.22, -1.65)
-1.62
(-1.95, -1.29)
-1.41
(-2.09, -0.74)
-0.83
(-1.39,-0.27)
-1.18
(-1.51,-0.85)
Age ≤ 51 y
(n = 127)
-8.12
(-12.35, -3.89)
-5.16
(-8.41, -1.91)
-1.59
(-1.89, -1.30)
-1.17
(-1.83, -0.51)
-0.75
(-1.28, -0.22)
-1.47
(-1.79, -1.15)
Age > 51 y
(n = 124)
-15.64
(-19.74, -11.54)
-10.17
(-13.48, -6.86)
-1.69
(-2.01, -1.38)
-1.87
(-2.48, -1.27)
-1.71
(-2.16, -1.26)
-1.50
(-1.85, -1.15)
  1. Mean Improvement = decrease; CI, confidence interval; HADS, Hospital Anxiety and Depression Scale; MOS-SS, Medical Outcomes Study-Sleep Scale; NRS, numeric rating scale; PII, Pain Interference Index; PROs, patient-reported outcomes.
  2. *30% and 50% responders are those patients who achieved at least a 30% and 50% reduction in pain, respectively, in the clinical trial on which this analysis was based.