Table 2 Mean Improvement in PROs Corresponding to a 2-Point Improvement in Pain for Patients and Preselected Subgroups
MEAN (95% CI) IMPROVEMENT IN PRO THAT CORRESPONDED TO A 2-POINT IMPROVEMENT IN PAIN | ||||||
|---|---|---|---|---|---|---|
GROUP | MOS-SS DISTURBANCE | MOS-SS 9-ITEM SLEEP PROBLEMS INDEX | SLEEP INTERFERENCE (NRS) | HADS ANXIETY | HADS DEPRESSION | PII |
All patients (N = 254) | -11.87 (-14.83, -8.91) | -7.59 (-9.91, -5.27) | -1.64 (-1.86, -1.43) | -1.52 (-1.97, -1.07) | -1.23 (-1.58,-0.88) | -1.48 (-1.72, -1.25) |
Subgroups | ||||||
30% responders (n = 82)* | -11.57 (-19.17, -3.98) | -7.41 (-13.31, -1.50) | -1.54 (-2.05, -1.03) | -1.57 (-2.61, -0.53) | -1.39 (-2.13,-0.65) | -1.68 (-2.22, -1.14) |
50% responders (n = 48)* | -13.12 (-25.04, -1.19) | -8.37 (-18.07,1.32) | -1.70 (-2.70,-0.70) | -2.04 (-3.88, -0.21) | -1.25 (-2.50,0) | -2.21 (-3.13,-1.28) |
Pregabalin- treated patients (n = 127) | -15.79 (-19.76, -11.83) | -9.85 (-13.14, -6.57) | -1.67 (-1.96, -1.38) | -1.64 (-2.25,-1.03) | -1.56 (-2.00,-1.12) | -1.71 (-2.05,-1.38) |
Placebo-treated patients (n = 127) | -7.09 (-11.51,-2.68) | -4.93 (-8.22, -1.65) | -1.62 (-1.95, -1.29) | -1.41 (-2.09, -0.74) | -0.83 (-1.39,-0.27) | -1.18 (-1.51,-0.85) |
Age ≤ 51 y (n = 127) | -8.12 (-12.35, -3.89) | -5.16 (-8.41, -1.91) | -1.59 (-1.89, -1.30) | -1.17 (-1.83, -0.51) | -0.75 (-1.28, -0.22) | -1.47 (-1.79, -1.15) |
Age > 51 y (n = 124) | -15.64 (-19.74, -11.54) | -10.17 (-13.48, -6.86) | -1.69 (-2.01, -1.38) | -1.87 (-2.48, -1.27) | -1.71 (-2.16, -1.26) | -1.50 (-1.85, -1.15) |