Table 2 General anxiety, depression (HADS), physical health (PCS), and heart-focused anxiety (CAQ-avoidance, -attention and -fear) scores of individuals with familial Long QT syndrome (LQTS) as compared to individuals with familial Hypertrophic cardiomyopathy (HCM).
Patient-reported outcomes | Familial LQTS | n | Familial HCM | n | p-value | |
|---|---|---|---|---|---|---|
HADS- | Total sample | 5.0 (4.1) | 87 | 4.7 (3.8) | 38 | 0.74 |
Anxiety (0-21) | At genetic risk | 5.1 (3.9) | 75 | 4.0 (3.5) | 18 | 0.29 |
With clinical diagnosis | 4.3 (5.2) | 12 | 5.3 (4.1) | 20 | 0.54 | |
HADS- | Total sample | 3.0 (4.0) | 87 | 3.3 (2.9) | 38 | 0.65 |
Depression (0-21) | At genetic risk | 3.1 (3.9) | 75 | 2.8 (3.1) | 18 | 0.76 |
With clinical diagnosis | 2.6 (4.8) | 12 | 3.9 (2.9) | 20 | 0.35 | |
SF36- | Total sample | 52.0 (7.1) | 84 | 47.1 (10.5) | 36 | 0.01 |
Physical health | At genetic risk | 52.2 (7.1) | 72 | 52.8 (7.6) | 17 | 0.75 |
Summary (0-100) | With clinical diagnosis | 51.0 (8.6) | 12 | 42.1 (10.2) | 19 | 0.02 |
CAQ- | Total sample | 0.7 (0.7) | 87 | 1.4 (0.9) | 38 | <0.01 |
Avoidance (0-4) | At genetic risk | 0.8 (0.7) | 75 | 1.1 (0.7) | 18 | 0.06 |
With clinical diagnosis | 0.6 (0.4) | 12 | 1.7 (1.0) | 20 | <0.01 | |
CAQ- | Total sample | 0.6 (0.6) | 88 | 1.1 (0.8) | 38 | 0.01 |
Attention (0-4) | At genetic risk | 0.6 (0.5) | 76 | 0.8 (0.7) | 18 | 0.11 |
With clinical diagnosis | 0.8 (0.9) | 12 | 1.3 (0.8) | 20 | 0.13 | |
CAQ- | Total sample | 1.0 (0.8) | 87 | 1.5 (0.7) | 38 | <0.01 |
Fear (0-4) | At genetic risk | 1.0 (0.7) | 75 | 1.4 (0.7) | 18 | 0.05 |
With clinical diagnosis | 1.3 (1.0) | 12 | 1.7 (0.8) | 20 | 0.34 |