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Table 3 Association of At-Goal A1C and Patient Reported Outcomes

From: Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary

Characteristic N Patients At Goal Patients Not At Goal p-value&
Self-reported hypoglycemic episodes     
   Patients with Hypoglycemic Symptoms (%) 114 27.5% 27.7% 0.968
   Patients without Hypoglycemic Symptoms (%) 299 72.5% 72.3%  
Symptom Severity     
   None (%) 299 72.5% 72.4% 0.663
   †Mild resulting into no or little interruption in activities (%) 76 19.7% 18.0%  
   †Moderate resulting into interruption in daily activities (%) 28 7.8% 6.4%  
   *†Severe requiring some kind of medical or non-medical assistance (%) 10 0% 3.2%  
EQ VAS Score (mean ± std) 414 77.0 ± 16.5 76.7 ± 15.5 0.854
Adherence & Barriers to Adherence     
   Always taking EXACTLY as prescribed (%) 221 62.1% 50.7% 0.049
   Never UNSURE about instructions (%) 323 80.6% 77.7% 0.534
   Never UNABLE to follow plans (%) 313 82.5% 73.8% 0.072
   Never BOTHERED by side effects (%) 266 73.8% 61.5% 0.024
   Never PROBLEMS getting Rx filled (%) 379 95.2% 91.5% 0.230
Satisfaction with Treatment     
   Effectiveness (mean ± std) 406 71.1 ± 16.3 65.9 ± 15.0 0.003
   Side Effects (mean ± std) 410 92.7 ± 14.9 90.1 ± 17.0 0.174
   Convenience (mean ± std) 412 67.3 ± 20.6 67.3 ± 17.8 0.986
   Global Satisfaction (mean ± std) 113 75.5 ± 15.4 70.8 ± 16.3 0.012
  1. % are based on column.
  2. Based on the Chi-square test of the null hypothesis of no association between patient reported experience of hypoglycemia and treatment adherence and barriers to adherence.
  3. &Based on the Wald test of the null joint hypothesis of no association of the severity symptoms with adequate glycemic control (i.e. all coefficients are equal to zero).
  4. Based on the t-test of the null hypothesis of no association between patient reported experience of hypoglycemia and specified characteristics * Reference category
  5. {Mild: Little or no interruption of activities, and didn't feel the need of assistance to manage symptoms, Moderate: Some interruption of activities, but didn't feel the need of assistance to manage symptoms, Severe: The severe symptoms group is a consolidation of the 'severe' and 'very severe' symptoms that were respectively defined as: Felt that you needed assistance of others to manage symptoms (for example, to bring you food or drink), and needed medical attention (for example, called an ambulance, visited an emergency room or hospital, or saw a doctor or nurse)}.