Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary

Table 3 Association of At-Goal A1C and Patient Reported Outcomes

Characteristic	N	Patients At Goal	Patients Not At Goal	p-value^&
Self-reported hypoglycemic episodes
Patients with Hypoglycemic Symptoms (%)	114	27.5%	27.7%	0.968
Patients without Hypoglycemic Symptoms (%)	299	72.5%	72.3%
Symptom Severity
None (%)	299	72.5%	72.4%	0.663
†Mild resulting into no or little interruption in activities (%)	76	19.7%	18.0%
†Moderate resulting into interruption in daily activities (%)	28	7.8%	6.4%
*†Severe requiring some kind of medical or non-medical assistance (%)	10	0%	3.2%
EQ VAS Score (mean ± std)	414	77.0 ± 16.5	76.7 ± 15.5	0.854
Adherence & Barriers to Adherence
Always taking EXACTLY as prescribed (%)	221	62.1%	50.7%	0.049
Never UNSURE about instructions (%)	323	80.6%	77.7%	0.534
Never UNABLE to follow plans (%)	313	82.5%	73.8%	0.072
Never BOTHERED by side effects (%)	266	73.8%	61.5%	0.024
Never PROBLEMS getting Rx filled (%)	379	95.2%	91.5%	0.230
Satisfaction with Treatment
Effectiveness (mean ± std)	406	71.1 ± 16.3	65.9 ± 15.0	0.003
Side Effects (mean ± std)	410	92.7 ± 14.9	90.1 ± 17.0	0.174
Convenience (mean ± std)	412	67.3 ± 20.6	67.3 ± 17.8	0.986
Global Satisfaction (mean ± std)	113	75.5 ± 15.4	70.8 ± 16.3	0.012

% are based on column.
^‡ Based on the Chi-square test of the null hypothesis of no association between patient reported experience of hypoglycemia and treatment adherence and barriers to adherence.
^&Based on the Wald test of the null joint hypothesis of no association of the severity symptoms with adequate glycemic control (i.e. all coefficients are equal to zero).
^¶ Based on the t-test of the null hypothesis of no association between patient reported experience of hypoglycemia and specified characteristics * Reference category
^† {Mild: Little or no interruption of activities, and didn't feel the need of assistance to manage symptoms, Moderate: Some interruption of activities, but didn't feel the need of assistance to manage symptoms, Severe: The severe symptoms group is a consolidation of the 'severe' and 'very severe' symptoms that were respectively defined as: Felt that you needed assistance of others to manage symptoms (for example, to bring you food or drink), and needed medical attention (for example, called an ambulance, visited an emergency room or hospital, or saw a doctor or nurse)}.

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