Figure 1

Flow diagram of 28 symptom domains in questionnaire and criteria for determining frequent and responsive symptom domains. Sixteen symptom domains were included from commonly used indices of ulcerative colitis disease activity (Truelove and Witts, St. Mark's Index, CAI, SCCAI, UCSS, Mayo, and UCDAI), and twelve novel symptom domains were included from previously conducted focus group input [15]. The questionnaire required ratings of the three criteria listed on a 100 mm Visual Analogue Scale for each of the 28 symptom domains. Symptom domains were determined to be either frequent and responsive or infrequent or unresponsive for evaluation of disease activity based on significance of the sign test.