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Table 5 Parent Proxy-Report: Means and Standard Deviations for the PedsQL™ 4.0 Generic Core Scales by Disease Category.

From: Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales

   Total Score Physical Health Psychosocial Health Emotional Functioning Social Functioning School Functioning
  n Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)
Asthma        
Mild Intermittenta 206 86.90 (13.23) 88.80 (14.37) 85.86 (15.63) 85.60 (17.84) 88.43 (17.26) 83.02 (20.97)
Mild Persistentb 68 76.77 (16.23) 76.15 (21.40) 77.11 (16.74) 74.54 (20.58) 82.23 (18.71) 75.00 (22.76)
Moderate to Severe Persistent c 63 69.88 (16.82) 64.76 (21.93) 72.65 (18.10) 69.84 (22.30) 76.85 (24.80) 71.39 (23.34)
Differences   a > b, c***; b > c* a > b, c***; b > c** a > b, c*** a > b, c*** a > c*** a > b*; a > c**
Cancer        
Acute Lymphoblastic Leukemiaa 170 71.29 (18.11) 71.20 (22.54) 71.35 (17.90) 67.57 (19.97) 77.00 (20.40) 68.03 (22.51)
Brain Tumor b 249 66.21 (19.22) 65.17 (25.24) 67.01 (18.89) 67.34 (21.11) 68.43 (23.92) 65.12 (23.53)
Newly Diagnosed On-Treatment¤ 180 66.95 (19.85) 65.00 (26.26) 68.19 (18.25) 63.26 (20.70) 75.58 (20.08) 63.61 (24.03)
Long-Term Survivor Off-Treatment > 12 months§ 94 73.64 (18.72) 74.80 (24.08) 72.95 (18.07) 72.93 (19.94) 76.28 (21.71) 68.87 (23.08)
Differences   a > b**;§ > ¤** a > b*; § > ¤** a > b*; § > ¤* § > ¤*** a > b*** _____
Cardiac        
Disease Severity Group 1 a 82 88.06 (12.04) 93.03 (10.39) 84.98 (14.63) 81.05 (19.23) 91.38 (14.19) 80.86 (17.88)
Disease Severity Group 2 b 143 80.50 (15.13) 84.32 (18.39) 78.28 (15.58) 75.78 (20.12) 84.55 (18.73) 72.68 (19.54)
Disease Severity Group 3 c 93 78.62 (16.21) 81.86 (18.63) 76.92 (17.57) 74.50 (20.97) 81.66 (20.40) 72.46 (20.36)
Disease Severity Group 4 d 108 73.42 (18.11) 75.37 (21.35) 72.41 (18.49) 70.10 (21.29) 76.17 (22.09) 68.68 (23.22)
Differences   a > b**; a > c, d***; b > d** b > d**; a > b**; a > c, d*** a > b*; a > c**; a > d***; b > d* a > d** a > c**; b > d**; a > d*** a > b*; a > d**
Cerebral Palsy        
Hemiplegiaa 49 57.67 (20.00) 55.72 (25.78) 58.94 (19.45) 62.19 (21.71) 55.92 (24.02) 57.26 (22.56)
Diplegiab 67 54.03 (15.87) 47.02 (22.15) 58.01 (15.97) 63.31 (19.32) 53.88 (20.29) 56.39 (20.40)
Paraplegiac 73 44.78 (15.30) 31.88 (27.19) 52.00 (14.80) 61.31 (17.61) 48.29 (20.62) 45.24 (19.65)
Differences   a > c***; b > c** a > c***; b > c** _____ _____ _____ a, b > c**
Diabetes        
Type 1 a 226 77.31 (14.12) 82.38 (17.82) 74.53 (15.17) 69.11 (18.64) 82.33 (18.78) 71.87 (19.11)
Type 2 b 78 74.71 (14.01) 81.06 (15.64) 71.28 (15.77) 69.47 (18.26) 77.21 (20.70) 67.42 (20.14)
Differences   _____ _____ _____ _____ a > b* _____
End Stage Renal Disease        
Transplanta 45 75.57 (17.75) 78.38 (24.65) 74.14 (17.50) 75.67 (18.36) 78.56 (22.20) 66.06 (18.53)
Peritoneal Dialysisb 19 68.07 (15.02) 68.40 (20.01) 67.97 (14.79) 62.11 (17.90) 73.42 (17.95) 69.30 (16.21)
Hemodialysisc 31 61.94 (17.70) 62.52 (23.45) 61.69 (17.23) 62.74 (19.79) 66.13 (19.27) 56.21 (25.62)
Differences   a > c** a > c* a > c** a > b, c* a > c* _____
Gastrointestinal Conditions        
Irritable Bowel Syndromea 122 74.82 (14.27) 78.68 (15.83) 72.72 (15.30) 66.19 (19.61) 82.54 (17.34) 69.35 (20.48)
Functional Abdominal Painb 82 73.65 (12.23) 77.70 (15.41) 71.49 (12.87) 65.49 (16.59) 79.94 (15.20) 68.93 (17.99)
Organic Disordersc 82 68.75 (16.97) 70.31 (18.82) 67.95 (18.03) 63.41 (21.30) 77.33 (21.29) 63.13 (20.96)
Differences   a > c* a > c* _____ _____ _____ _____
Obesity        
Severely Obesea 105 63.30 (19.20) 63.60 (24.00) 63.10 (18.60) 60.90 (21.70) 67.20 (26.10) 61.40 (21.50)
Obeseb 63 75.00 (14.50) 76.30 (17.60) 73.90 (15.30) 72.60 (17.80) 73.50 (17.30) 76.60 (17.00)
Overweightc 294 80.00 (13.60) 82.60 (17.20) 76.10 (14.40) 74.90 (15.80) 82.30 (16.10) 78.40 (17.10)
Differences   b, c > a***; c > b** c > b**; c > a***; b > a** b, c > a*** c > a***; b > a** c > a***; c > b** b, c > a***
Psychiatric Disorders        
Attention-Deficit and Disruptive Behavior Disordersa 107 65.80 (13.50) 80.30 (16.20) 58.00 (15.40) 54.90 (18.70) 59.10 (22.50) 59.80 (17.80)
Anxiety Disordersb 57 66.00 (14.20) 80.30 (17.60) 58.20 (15.10) 46.80 (16.70) 66.30 (25.70) 62.00 (17.80)
Mood Disorders c 29 65.70 (11.70) 79.20 (17.80) 58.60 (12.30) 49.10 (16.90) 66.20 (18.40) 60.60 (16.70)
Pervasive Developmental Disorders d 28 61.50 (13.10) 76.30 (22.00) 53.70 (12.40) 53.70 (14.00) 47.20 (20.20) 61.40 (15.80)
Differences   _____ _____ _____ a > b** _____ _____
Rheumatology        
Systemic Lupus Erythematosusa 18 75.25 (17.69) 70.16 (25.35) 78.00 (15.67) 72.50 (21.71) 83.61 (16.79) 78.53 (17.30)
Spondyloarthritisb 33 73.63 (18.20) 70.08 (27.65) 75.49 (15.31) 75.00 (17.94) 81.09 (19.17) 70.61 (18.91)
Juvenile Rheumatoid Arthritisc 124 73.48 (18.95) 70.07 (24.07) 75.36 (18.13) 74.58 (19.89) 76.73 (20.89) 74.66 (22.50)
Fibromyalgiad 57 52.07 (15.17) 43.37 (19.01) 56.70 (16.41) 48.95 (19.47) 67.02 (19.70) 53.77 (20.55)
Differences   a, b, c > d*** a, b, c > d*** a, b, c > d*** a, b, c > d*** a, b, c > d* a, b > d**; c > d***
  1. Note: *p < .05, **p < .01, ***p < .001 based on Tukey post-hoc analysis when more than 2 disease categories are being compared and independent samples t-test when 2 disease categories are being compared. Contrasts for cancer disease categories are for Acute Lymphoblastic Leukemiaa versus Brain Tumorband Newly Diagnosed On-Treatment ¤ versus Long Term Survivor Off-Treatment > 12 months §. Asthma contrasts are based on the PedsQL™ 4.0 SF15, a shorted version of the 23-item PedsQL™ 4.0 Generic Core Scales.