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Table 2 Percentage of patients with treatment success for heartburn by overall treatment effect group

From: Responsiveness of measures of heartburn improvement in non-erosive reflux disease

  Treatment success definition  
  Worse
(n = 35)
Unchanged
(n = 181)
Somewhat better
(n = 83)
A good deal better
(n = 247)
A great deal better
(n = 314)
A very great deal better
(n = 780)
All
(n = 1640)
GSRS score at 4 weeks
0 (no HB) 5.7 13.3 21.7 32.0 57.6 87.8 60.3
≤ 1 (minor HB) 17.1 35.4 55.4 66.4 84.1 97.2 79.4
≤ 2 (mild HB) 37.1 59.7 86.7 88.3 95.2 99.0 90.4
Inv-assessed severity
0 (no HB) 8.6 14.4 20.5 34.8 61.1 87.4 61.3
≤ 1 (mild HB) 34.3 61.3 85.5 86.6 95.5 98.7 90.1
Inv-assessed frequency
≤ 1 day with HB 8.6 17.1 31.3 44.9 71.0 92.2 67.9
≤ 2 days with HB 8.6 24.9 43.4 56.7 80.3 96.2 74.8
≤ 3 days with HB 17.1 30.4 55.4 70.9 86.9 98.2 80.5
No. of score units improved in GSRS
≥ 1 31.4 60.8 83.1 85.4 91.7 99.0 89.1
≥ 2 28.6 33.7 59.0 70.0 82.8 97.1 79.9
≥ 3 20.0 21.0 39.8 47.0 69.7 92.4 69.1
≥ 50% improvement in GSRS 25.7 25.4 49.4 62.3 78.0 96.8 76.2
≥ 1 grade (Inv) improvement 45.7 68.5 89.2 91.1 96.5 99.0 92.3
Improvement in Inv-assessed frequency
≥ 1 day 42.9 48.1 68.7 85.0 92.0 99.4 87.4
≥ 2 days 28.6 39.2 57.8 77.3 90.1 98.8 83.8
≥ 3 days 17.1 28.7 50.6 66.8 85.0 97.7 78.9
  1. GSRS = Gastrointestinal Symptom Rating Scale; HB = heartburn; Inv = investigator.