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Table 4 Minimal Clinically Important Difference

From: The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis

Average Difference Between Adjacent PRO Scores

Scale

12.5% Difference in nail clearing*

25% Difference in nail clearing*

≥ 5 mm new nail growth

Symptom Frequency

6.48

9.12

17.28

Symptom Bothersomeness

5.95

5.84

11.83

Physical Activities Problems

7.54

8.32

17.69

Appearance Problems

8.04

8.69

18.51

Overall Problem

11.19

11.77

25.32

Stigma

5.44

5.21

9.41

Treatment Satisfaction

7.42

9.11

16.37

Overall

7.30

8.45

16.63

  1. * Based on comparisons that are significant at the .05 level
  2. Based on comparisons that are significant at the .0001 level