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Table 4 Minimal Clinically Important Difference

From: The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis

Average Difference Between Adjacent PRO Scores
Scale 12.5% Difference in nail clearing* 25% Difference in nail clearing* ≥ 5 mm new nail growth
Symptom Frequency 6.48 9.12 17.28
Symptom Bothersomeness 5.95 5.84 11.83
Physical Activities Problems 7.54 8.32 17.69
Appearance Problems 8.04 8.69 18.51
Overall Problem 11.19 11.77 25.32
Stigma 5.44 5.21 9.41
Treatment Satisfaction 7.42 9.11 16.37
Overall 7.30 8.45 16.63
  1. * Based on comparisons that are significant at the .05 level
  2. Based on comparisons that are significant at the .0001 level