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Table 1 Characteristics and results of the study population in subgroups

From: Validation of the Clinical COPD questionnaire in Italian language

  Healthy subjects Mild-moderate COPD-class I-II Severe COPD-class III Very severe COPD-class IV
N 55 40 55 25
Males (%) 62.0 85.0 63.6 72.0
Age (yr) 70abcd (41–82) 72abcd (58–84) 71abcd (41–86) 71abcd (42–86)
LTOT (%) 0.0 0.0 32.7 72.0
HMV (%) 0.0 0.0 7.2 8.0
BMI (kg/m2) 25.7abcd (18.0–30.0) 26.7abcd (18.6–37.8) 25.1abcd (16.4–36.4) 26.6abcd (16.2–34.6)
FEV1/FVC (%) 79.2 (70.4–94.5) 59.7 (40.4–68.2) 44.2 (27.9–66.2) 35.1 (21.1–57.3)
FEV1 (% predicted) 108.0 (69–132) 69.5 (51.4–117.1) 40.7 (30.2–49.8) 26.4 (16.4–29.7)
MRC functional dyspnoea 0.6 ± 3.4 (0–1) 1.1 ± 0.8 (0–2) 1.6 ± 0.7 (0–4) 2.3 ± 0.9 (0–4)
CCQ symptom 0.5 (0.0–4.0) 1.3b (0.0–4.0) 1.5b (0.3–5.8) 2.5 (0.3–3.8)
CCQ functional state 0.5a (0.0–5.3) 1.0a (0.0–3.5) 1.5 (0.0–5.3) 3.0 (0.3–5.0)
CCQ mental state 0.0 (0.0–4.5) 0.0 (0.0–5.0) 1.0c (0.0–6.0) 1.5c (0.0–6.0)
CCQ total 0.4 (0.0–3.8) 0.9 (0.0–3.5) 1.4 (0.3–5.2) 2.6 (0.4–4.3)
  1. CCQ = Clinical COPD Questionnaire; range 0–6; 0 indicating best possible control and 6 indicating worst clinical control. LTOT = long term oxygen therapy. HMV = home assisted mechanical ventilation during night. BMI = body mass index. FVC = forced vital capacity. FEV1 = forced expired volume in one second. MRC = Medical Research Council. Healthy: normal spirometry, no chronic symptoms (cough, sputum production and/or dyspnoea). COPD classification by post-bronchodilator spirometry according to GOLD guidelines: mild-moderate FEV1/FVC <= 0.70 and FEV1 >= 50% predicted, severe FEV1/FVC <= 0.70 and FEV1 >= 30% predicted, very-severe FEV1/FVC <= 0.70 and FEV1 < 30% predicted. Medians not sharing a common superscript (a,b,c,d) are significantly different at p < 0.05 after Mann-Wittney U test.
  2. MRC data are reported as mean value with standard deviation and range.