The reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a trial population

Table 6 Changes in RLSQoL overall life impact scores from baseline to week 12: effect sizes and a comparison between CGI-I levels 1–7 (TREAT RLS 2)

	n	Baseline mean	Baseline SD (total)	Week 12 mean	Mean change	Effect size	Kruskal-Wallis test (p value)
Very much improved	74	63.78	18.83	92.15	28.47	1.51	0.0001
Much improved	43	59.19	18.83	77.94	18.75	1.00
Minimally improved	45	66.72	18.83	76.94	10.22	0.54
No change	37	65.48	18.83	71.39	5.91	0.31
Minimally worse	6	60.83	18.83	70.83	10.00	0.53
Very much worse	1	80.00	18.83	85.00	5.00

p < 0.0001 for comparisons of the change in RLSQoL overall life impact scores among CGI-I groups in TREAT RLS 2 (Kruskall-Wallis test). There were no patients included in the CGI-I 'much worse' category. The 'very much worse' group consisted of a single patient and therefore further statistical tests were not performed for this group. Effect sizes were calculated by dividing the change in mean score (from baseline to week 12) by the standard deviation of the mean score at baseline.
RLSQoL = RLS Quality of Life questionnaire. CGI-I = Clinical Global Impression 'Improvement'.

ISSN: 1477-7525