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Table 5 Changes in RLSQoL overall life impact scores from baseline to week 12: effect sizes and a comparison between CGI-I levels 1–7 (TREAT RLS 1)

From: The reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a trial population

  n Baseline mean Baseline SD (total) Week 12 mean Mean change Effect size Kruskal-Wallis test (p value)
Very much improved 68 64.33 18.25 91.95 27.62 1.51 0.0001
Much improved 59 62.41 18.25 83.47 21.06 1.15  
Minimally improved 36 57.84 18.25 71.38 13.54 0.74  
No change 51 58.65 18.25 65.41 6.76 0.37  
Minimally worse 5 76.13 18.25 82.61 6.48 0.36  
Much worse 9 58.33 18.25 57.53 -0.8 -0.04  
  1. p < 0.0001 for comparisons of the change in RLSQoL overall life impact scores among CGI-I groups in TREAT RLS 1 (Kruskall-Wallis test). There were no patients included in the CGI-I 'very much worse' category. Effect sizeswere calculated by dividing the change in mean score (from baseline to week 12) by the standard deviation of the mean score at baseline. RLSQoL = RLS Quality of Life questionnaire. CGI-I = Clinical Global Impression 'Improvement'.