Table 3 Improvement of Köhne prognostic index

Variable

HR (95% CI)

P value

NRI (95% CI)

Köhne (2 vs. 1)

1.18 [0.96 – 1.47]

=0.1200

Köhne (3 vs. 1)

2.66 [1.84 – 3.85]

<0.0001

Improvement of the Köhne prognostic index with clinical and QoL factors: complete-case analysis

   Köhne (2 vs. 1)

1.11 [0.80 – 1.55]

=0.5114

NRI at 12 months = 0.23 ([0.07; 0.46])

NRI at 24 months = 0.31 ([0.16; 0.44])

Köhne (3 vs. 1)

2.17 [1.25 – 3.75]

=0.0056

NRI at 36 months = 0.27 ([0.02; 0.50])

LDH (>1ULN vs. ≤ 1ULN)

2.09 [1.53 – 2.87]

<0.0001

Mobility (2–3 vs. 1)

1.56 [1.05 – 2.32]

=0.0266

Pain/discomfort (2–3 vs. 1)

1.60 [1.17 – 2.18]

=0.0031

Improvement of the Köhne prognostic index with clinical and QoL factors after multiple imputation

Köhne (2 vs. 1)

1.24 [0.97 – 1.58]

=0.0780

Köhne (3 vs. 1)

2.15 [1.43 – 3.24]

=0.0002

LDH (>1ULN vs. ≤ 1ULN)

1.99 [1.61 – 2.46]

<0.0001

Mobility (2–3 vs. 1)

1.39 [1.06 – 1.83]

=0.0191

Pain/discomfort (2–3 vs. 1)

1.67 [1.20 – 2.31]

=0.0031