Table 2 Univariate and multivariate Cox analyses
Univariate analysis | Multivariate analysis | Multivariate analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Model not including QoL | Full model, including QoL | |||||||||
Variable | Class | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P |
Age | ≤65 | 1 | ||||||||
>65 | 1.42 | 1.06 – 1.89 | 0.0178 | |||||||
Gender | Male | 1 | ||||||||
Female | 1.06 | 0.79 – 1.42 | 0.6945 | |||||||
PS | 0 | 1 | 1 | 1 | ||||||
1-2 | 1.84 | 1.38 – 2.46 | <0.0001 | 1.98 | 1.44 – 2.73 | <0.0001 | 1.87 | 1.35 – 2.59 | 0.0002 | |
Number of sites | 1 | 1 | 1 | 1 | ||||||
>1 | 1.47 | 1.10 – 1.97 | 0.0094 | 1.48 | 1.08 – 2.05 | 0.0160 | 1.48 | 1.07 – 2.04 | 0.0176 | |
Liver involvement | No | 1 | ||||||||
Yes | 1.14 | 0.795 – 1.65 | 0.4699 | |||||||
Metastases | Synchronous | 1 | ||||||||
Metachronous | 0.89 | 0.61 – 1.29 | 0.5403 | |||||||
Adjuvant chemotherapy | No | 1 | ||||||||
Yes | 0.95 | 0.76 – 1.19 | 0.68 | |||||||
LDH | ≤1xULN | 1 | 1 | 1 | ||||||
>1xULN | 2.04 | 1.48 – 2.80 | <0.0001 | 1.93 | 1.39 – 2.68 | <0.0001 | 1.83 | 1.31 – 2.55 | 0.0004 | |
APL | ≤1xULN | 1 | ||||||||
>1xULN | 1.60 | 1.20 – 2.14 | 0.0016 | |||||||
CEA | ≤1xULN | 1 | ||||||||
>1xULN | 1.48 | 1.01 – 2.18 | 0.0444 | |||||||
EuroQoL | ||||||||||
Mobility | 1 | 1 | 1 | |||||||
2-3 | 1.90 | 1.33 – 2.71 | 0.0004 | 1.66 | 1.12 – 2.48 | 0.0117 | ||||
Self-care | 1 | 1 | ||||||||
2-3 | 1.52 | 0.88 – 2.62 | 0.1322 | |||||||
Usual activities | 1 | 1 | ||||||||
2-3 | 1.20 | 0.88 – 1.64 | 0.2553 | |||||||
Pain/discomfort | 1 | 1 | ||||||||
2-3 | 1.39 | 1.04 – 1.86 | 0.0239 | |||||||
Anxiety/depression | 1 | 1 | ||||||||
2-3 | 1.45 | 1.09 – 1.93 | 0.0116 | |||||||
VAS score | 1.001 | 0.996 – 1.005 | 0.7975 | |||||||
Harrell’s C index | 0.65 [0.61 – 0.69] | 0.67 [0.63 – 0.71] | ||||||||
0.65* | 0.66* | |||||||||
Schemper statistic | 9.32% | 10.42% | ||||||||