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Table 4 Main recalibration profiles highlighted by a multiple correspondence analysis performed on the EORTC QLQ-C30

From: Item response theory and factor analysis as a mean to characterize occurrence of response shift in a longitudinal quality of life study in breast cancer patients

Dimension (items) Time points N Percentage of recalibration (number of patients) Recalibration category 1 to category 2 Recalibration category 2 to category 1 Recalibration category 3 to category 4 Recalibration category 4 to category 3 Categories 3 and 4 dispersed
Physical functioning T1 - T2_Ra 100 37% (272) Q1-Q5 Q1-Q5    Q1-Q5
(Q1, Q5) T1 - T3_Rb 139 51% (274) Q1-Q5 Q1-Q5    Q1-Q5
  T3 - T4_Rc 201 76% (266) Q1-Q5 Q1-Q5    Q1-Q5
Role functioning T1 - T2_R 84 31% (272) Q6, Q7 Q6, Q7    Q6, Q7
(Q6-Q7) T1 - T3_R 118 43% (274) Q6, Q7 Q6, Q7 Q6, Q7 Q6, Q7  
  T3 - T4_R 164 63% (261) Q6, Q7 Q6, Q7    Q6, Q7
Emotional functioning T1 - T2_R 180 68% (263) Q21-Q24 Q21-Q24    
(Q21-Q24) T1 - T3_R 208 79% (263) Q21-Q24 Q21-Q24    
  T3 - T4_R 196 77% (255) Q21-Q24 Q21-Q24    Q21-Q24
Cognitive functioning T1 - T2_R 103 39% (266) Q20, Q25     
(Q20, Q25) T1 - T3_R 129 48% (268) Q20, Q25 Q20, Q25 Q20, Q25 Q20, Q25 Q20, Q25
  T3 - T4_R 130 51% (256) Q20, Q25 Q20, Q25 Q20, Q25 Q20, Q25  
Social functioning T1 - T2_R 75 29% (260) Q26, Q27 Q26, Q27    Q26, Q27
(Q26, Q27) T1 - T3_R 101 38% (268) Q26, Q27 Q26, Q27 Q26, Q27 Q26, Q27  
  T3 - T4_R 142 56% (255) Q26, Q27 Q26, Q27 Q26, Q27 Q26, Q27 Q26, Q27
Fatigue T1 - T2_R 141 54% (259) Q10, Q12, Q18 Q10, Q12, Q18    Q10, Q12, Q18
(Q10, Q12, Q18) T1 - T3_R 160 61% (261) Q10, Q12, Q18 Q10, Q12, Q18 Q12 Q10, Q12, Q18 Q10, Q12, Q18
  T3 - T4_R 183 73% (251) Q10, Q12, Q18 Q10, Q12, Q18   Q10, Q12, Q18 Q10, Q12, Q18
Nausea and vomiting T1 - T2_R 37 13% (280) Q14 Q14, Q15    Q14, Q15
(Q14, Q15) T1 - T3_R 65 24% (275) Q14 Q14   Q14  
  T3 - T4_R 98 37% (265) Q14 Q14    
Pain T1 - T2_R 96 36% (267) Q9 Q9    Q9, Q19
(Q9, Q19) T1 - T3_R 124 46% (268) Q9, Q19 Q9, Q19    Q9, Q19
  T3 - T4_R 148 58% (253) Q9, Q19 Q9, Q19   Q9, Q19  
Insomnia T1 - T2_R 115 42% (277) Q11 Q11   Q11  
(Q8) T1 - T3_R 135 49% (274) Q11 Q11 Q11 Q11  
  T3 - T4_R 147 55% (266) Q11 Q11 Q11 Q11  
Dyspnea T1 - T2_R 50 18% (280) Q8 Q8   Q8  
(Q11) T1 - T3_R 55 20% (279) Q8 Q8 Q8 Q8  
  T3 - T4_R 94 35% (269) Q8 Q8 Q8 Q8  
Appetite loss T1 - T2_R 61 22% (280) Q13 Q13   Q13  
(Q13) T1 - T3_R 85 30% (280) Q13 Q13   Q13  
  T3 - T4_R 90 34% (267) Q13 Q13   Q13  
Constipation T1 - T2_R 71 26% (276) Q16 Q16 Q16 Q16  
(Q16) T1 - T3_R 89 32% (277) Q16 Q16 Q16 Q16  
  T3 - T4_R 93 35% (264) Q16 Q16 Q16 Q16  
Diarrhea T1 - T2_R 39 14% (278) Q17 Q17    
(Q17) T1 - T3_R 64 23% (277) Q17 Q17    
  T3 - T4_R 61 24% (263) Q17 Q17   Q17  
Financial difficulties T1 - T2_R 22 8% (264) Q28 Q28    
(Q28) T1 - T3_R 33 12% (269) Q28 Q28   Q28  
  T3 - T4_R 47 18% (264) Q28 Q28   Q28  
  1. Only patients with a recalibration of 5-point at least between a pre-test and a then-test measure are incorporated in these analyses. Items with observed recalibration are listed.
  2. aT1 → T2_R: comparison of baseline HRQoL assessment and retrospective measure performed after surgery.
  3. bT1 → T3_R: comparison of baseline HRQoL assessment and retrospective measure performed three months later.
  4. cT3 → T4_R: comparison of HRQoL assessment at three months and retrospective measure performed three months later.
  5. As example, 100 patients presented a significant recalibration of physical functioning among the 272 patients with all the five items of the dimension answered at both measurement time. The graph representing the response categories highlight some recalibration profile:
  6. - patients who had chosen response category 1 at the prospective measurement time for all the 5 items and who had chosen response category 2 to the same items at the retrospective measurement time.
  7. - patients who had chosen response category 2 at the prospective measurement time for all the 5 items and who had chosen response category 1 to the same items at the retrospective measurement time.
  8. - no recalibration profile is highlighted for response categories 3 and 4 and few patients had chosen these categories of response (these response categories are dispersed).