All patients
| |
Mean (SE)
|
64.89 (2.63)
|
54.90 (2.64)
|
72.55 (2.58)
|
51.63 (2.98)
|
43.32 (3.10)
|
66.48 (2.58)
|
71.36 (2.14)
|
-
|
60.62 (2.01)
|
-
|
Treated patients
| |
Mean (SE)
|
65.16 (2.88)
|
57.69 (2.80)
|
73.41 (2.79)
|
52.01 (3.17)
|
46.66 (3.40)
|
66.52 (2.73)
|
71.05 (2.27)
|
81.08 (1.63)
|
61.66 (2.21)
|
64.07 (2.06)
|
Sociodemographic factors
|
Male gender
|
+8.18 (7.43)
|
+13.56 (7.36)
|
+2.01 (7.33)
|
-9.81 (8.41)
|
+9.77 (8.71)
|
+4.18 (7.32)
|
+3.09 (6.05)
|
+7.36 (4.86)
|
+4.29 (5.67)
|
+4.50 (6.18)
|
Transmission (ref: heterosexual/unknown)
|
IDU
|
+11.61 (11.65)
|
+14.29 (11.65)
|
-0.89 (11.49)
|
+2.28 (13.14)
|
+27.39 (13.43)*
|
+1.64 (11.49)
|
+1.29 (9.48)
|
+3.46 (6.77)
|
+8.51 (8.89)
|
+7.60 (8.57)
|
MSM
|
+3.51 (5.49)
|
+3.17 (5.49)
|
-2.28 (5.42)
|
-8.60 (6.19)
|
+8.41 (6.36)
|
+2.56 (5.42)
|
-3.01 (4.47)
|
+4.34 (3.46)
|
+0.82 (4.21)
|
+2.20 (4.41)
|
Caucasian race
|
+11.38 (6.33)
|
+18.93 (6.16)†
|
+4.84 (6.29)
|
-2.75 (7.29)
|
+5.98 (7.52)
|
+10.87 (6.22)
|
+4.29 (5.20)
|
+11.34 (4.04)†
|
+7.52 (4.84)
|
+9.16 (5.23)
|
Age >45 years
|
+9.04 (5.22)
|
+12.21 (5.16)*
|
+8.24 (5.13)
|
+12.32 (5.87)*
|
+11.00 (6.13)
|
+5.18 (5.17)
|
+6.27 (4.25)
|
+9.25 (3.12)†
|
+9.02 (3.95)*
|
+9.23 (4.02)*
|
Living alone
|
-0.33 (5.42)
|
-2.15 (5.42)
|
-11.91 (5.18)*
|
-16.74 (5.91)†
|
-6.87 (6.36)
|
-2.18 (5.32)
|
-6.44 (4.35)
|
+2.82 (3.38)
|
-7.05 (4.1)
|
-4.23 (4.29)
|
Diagnosed <2 years
|
-0.98 (7.27)
|
-22.96 (6.91)†
|
-2.65 (7.13)
|
-3.79 (8.24)
|
-18.98 (8.32)*
|
+4.54 (7.13)
|
+6.54 (5.86)
|
-7.04 (5.61)
|
-5.34 (5.52)
|
-3.04 (7.12)
|
Unemployed or
|
-23.14 (6.54)‡
|
-5.95 (6.92)
|
-20.63 (6.49)†
|
-16.88 (7.69)*
|
-2.01 (8.14)
|
-25.92 (6.3)‡
|
-27.45 (4.91)‡
|
-10.32 (4.07)*
|
-17.32 (4.99)‡
|
-16.34 (5.01)†
|
sickness benefits
| | | | | | | | | | |
Post-secondary
|
+8.44 (5.44)
|
+3.18 (5.5)
|
-0.4 (5.4)
|
-0.8 (6.24)
|
-0.65 (6.47)
|
+3.03 (5.39)
|
+8.22 (4.39)
|
-0.92 (3.42)
|
+3.2 (4.19)
|
+2.17 (4.31)
|
education
| | | | | | | | | | |
Substance use over previous 2 weeks
|
Tobacco
|
+1.1 (5.4)
|
+1.49 (5.4)
|
-8.65 (5.22)
|
+6.95 (6.08)
|
+1.75 (6.37)
|
-4.62 (5.28)
|
-7.68 (4.31)
|
-0.81 (3.31)
|
-1.69 (4.13)
|
-1.09 (4.2)
|
Alcohol
|
-3.29 (7.46)
|
+10.37 (7.41)
|
-0.06 (7.33)
|
+0.04 (8.47)
|
-0.96 (8.76)
|
+4.12 (7.32)
|
+1.92 (6.06)
|
+3.18 (4.44)
|
+1.88 (5.69)
|
+3.57 (5.6)
|
Variance explained by sociodemographic factors
|
(proportion)
|
18.01%
|
22.49%
|
19.64%
|
20.7%
|
18.74%
|
20.69%
|
32.63%
|
20.6%
|
22.61%
|
21.22%
|
Treatment factors
|
On ART
|
+1.82 (7.47)
|
+18.94 (7.24)*
|
+5.92 (7.31)
|
+2.57 (8.47)
|
+22.49 (8.46)†
|
+0.27 (7.33)
|
-2.08 (6.06)
|
-
|
+7.00 (5.65)
|
-
|
Current ART (ref: NNRTI)
|
none
|
- 3.79 (7.96)
|
-19.27 (7.74)*
|
-7.50 (7.80)
|
-6.44 (8.98)
|
-15.00 (8.80)
|
-2.09 (7.82)
|
-2.99 (6.30)
|
-
|
-7.95 (6.04)
|
-
|
PI
|
-4.16 (5.75)
|
-0.70 (5.59)
|
-3.35 (5.63)
|
-8.23 (6.48)
|
+15.71 (6.37)*
|
-3.86 (5.65)
|
-10.76 (4.55)*
|
-9.93 (3.10)†
|
-1.99 (4.37)
|
-2.97 (4.13)
|
Time on HAART
|
+0.23 (0.5)
|
+1.38 (0.47)†
|
-0.07 (0.49)
|
-0.04 (0.56)
|
+1.44 (0.57)*
|
-0 (0.48)
|
-0.12 (0.4)
|
+0.36 (0.28)
|
+0.43 (0.38)
|
+0.42 (0.36)
|
(per year) ^
| | | | | | | | | | |
ART pill burden
|
-2.78 (2)
|
-0.68 (1.96)
|
-2.06 (1.94)
|
-3.74 (2.18)
|
+3.06 (2.36)
|
-2.12 (1.9)
|
-3.06 (1.55)
|
-3.36 (1.08)†
|
-1.56 (1.54)
|
-1.78 (1.43)
|
(per tablet/day) ^
| | | | | | | | | | |
ART non-adherent^
|
-2.48 (7.16)
|
+2.13 (6.96)
|
-3.26 (6.93)
|
-7.21 (7.84)
|
-2.8 (8.4)
|
-1.57 (6.79)
|
-6.58 (5.58)
|
-9.22 (3.91)*
|
-2.95 (5.46)
|
-3.72 (5.07)
|
On non-ART
|
-8.00 (5.41)
|
-2.57 (5.47)
|
-6.05 (5.34)
|
-6.45 (6.17)
|
+8.08 (6.38)
|
-11.07 (5.26)*
|
-12.39 (4.26)†
|
-1.19 (3.34)
|
-5.35 (4.14)
|
-4.61 (4.18)
|
medication
| | | | | | | | | | |
Variance explained by treatment factors
|
(proportion)
|
8.33%
|
20.27%
|
4.02%
|
5.39%
|
17.01%
|
6.51%
|
14.28%
|
26.55%
|
10.18%
|
10.18%
|
Biological factors
| | | | | | | | | | |
Body mass index
| | | | | | | | | | |
(per unit)
|
-0.01 (0.58)
|
-0.35 (0.58)
|
-0.29 (0.57)
|
+0.20 (0.66)
|
+0.02 (0.68)
|
+0.08 (0.57)
|
-0.18 (0.47)
|
+0.16 (0.35)
|
-0.07 (0.44)
|
-0.01 (0.44)
|
CD4 count (per 100
| | | | | | | | | | |
T cells)
|
+0.25 (0.82)
|
+1.50 (0.81)
|
+0.30 (0.81)
|
+1.90 (0.91)*
|
+0.22 (0.97)
|
+0.80 (0.80)
|
+0.42 (0.66)
|
+0.88 (0.47)
|
+0.81 (0.62)
|
+0.84 (0.60)
|
Detectable viral
| | | | | | | | | | |
load
|
-9.13 (6.08)
|
-17.09 (5.92)†
|
-10 (5.95)
|
-6.36 (6.94)
|
-13.05 (7.10)
|
-5.94 (6.01)
|
-0.87 (4.99)
|
-10.52 (4.61)*
|
-8.79 (4.6)
|
-10.96 (5.86)
|
Variance explained by biological factors
|
(proportion)
|
2.99%
|
11.15%
|
3.31%
|
4.57%
|
3.47%
|
2.07%
|
2.49%
|
10.00%
|
4.80%
|
5.51%
|
Clinical factors
| | | | | | | | | | |
Depressive
|
-27.84 (5.41)‡
|
-11.26 (5.95)
|
-19.64 (5.63)‡
|
-20.76 (6.51)†
|
+4.91 (7.12)
|
-17.22 (5.69)†
|
-24.26 (4.27)‡
|
-6.49 (3.67)
|
-16.48 (4.29)‡
|
-16.42 (4.29)‡
|
Other comorbidity
|
-10.5 (5.21)*
|
+0.27 (5.32)
|
-3.97 (5.2)
|
-3.95 (6.02)
|
+9.49 (6.2)
|
-7.59 (5.16)
|
-8.61 (4.23)*
|
-3.35 (3.27)
|
-3.35 (4.06)
|
-4.35 (4.14)
|
Symptoms
| | | | | | | | | | |
Sexual dysfunction
|
-26.02 (5.57)‡
|
-22.06 (5.75)‡
|
-6.69 (6.00)
|
-23.14 (6.58)‡
|
-12.38 (7.11)
|
-14.88 (5.85)*
|
-23.6 (4.40)‡
|
-7.86 (3.73)*
|
-18.29 (4.31)‡
|
-16.03 (4.49)‡
|
Gastrointestinal
|
-6.73 (1.53)‡
|
-3.99 (1.63)*
|
-4.2 (1.59)†
|
-5.38 (1.82)†
|
-0.31 (1.97)
|
-5.63 (1.54)‡
|
-8.57 (1.05)‡
|
-3.3 (0.94)‡
|
-4.95 (1.18)‡
|
-5.06 (1.15)‡
|
(per number)
| | | | | | | | | | |
Malaise (per
|
-8.11 (1.58)‡
|
-4.75 (1.71)†
|
-6.44 (1.62)‡
|
-4.28 (1.97)*
|
+0.17 (2.09)
|
-8.29 (1.53)‡
|
-9.18 (1.11)‡
|
-2.21 (1.12)
|
-5.95 (1.22)‡
|
-5.84 (1.3)‡
|
number)
| | | | | | | | | | |
Morphological
|
-4.71 (1.36)‡
|
-2.2 (1.42)
|
-2.75 (1.38)*
|
-5.29 (1.54)‡
|
-1.04 (1.68)
|
-4.81 (1.33)‡
|
-4.97 (1.05)‡
|
-1.76 (0.84)*
|
-3.65 (1.03)‡
|
-3.66 (1.01)‡
|
(per number)
| | | | | | | | | | |
Other (per number)
|
-8.39 (2.5)†
|
-4.6 (2.6)
|
-5.32 (2.53)*
|
-4.34 (2.96)
|
-0.8 (3.15)
|
-11.06 (2.34)‡
|
-9.17 (1.93)‡
|
-2.48 (1.58)
|
-6.71 (1.93)‡
|
-7.01 (1.91)‡
|
Variance explained by clinical factors
|
(proportion)
|
37.25%
|
19.37%
|
19.68%
|
21.82%
|
6.7%
|
29.97%
|
62.04%
|
14.2%
|
31.92%
|
33.31%
|
Variance explained by all factors
|
(proportion)
|
63.64%
|
49.81%
|
37.24%
|
46.31%
|
33.07%
|
41.26%
|
75.36%
|
47.83%
|
53.01%
|
55.4%
|