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Table 4 Multivariable pattern mixture models

From: Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study

 

“All Children” Model

“Adolescent only” Model

 

β( SE)

p-value

β( SE)

p-value

Intercept

49.7 (4.1)

<.0001

90.3 (13.5)

<.0001

Time

    

 Baseline (reference)

    

 45 days

-8.5 (2.4)

.0003

-3.2 (3.4)

0.35

 3 months

-8.0 (2.6)

.002

-6.0 (3.7)

0.11

 6 months

-4.8 (2.6)

.07

-3.5 (4.1)

0.39

 12 months

2.0 (4.8)

.68

-0.1 (5.1)

0.98

Baseline timing

-11.8 (2.7)

<.0001

-14.3 (3.4)

<.0001

Time*Baseline timing

    

 Baseline*baseline timing (reference)

    

 45 days*baseline timing

7.5 (3.4)

.03

8.6 (4.7)

0.06

 3 months*baseline timing

6.8 (3.7)

.07

9.7 (4.9)

0.048

 6 months*baseline timing

11.5 (3.7)

.002

11.7 (5.3)

0.03

 12 months*baseline timing

9.6 (5.8)

.10

8.8 (6.3)

0.16

Baseline parental emotional functioning for ½ SD changea

3.8 (0.4)

<.0001

2.2 (0.7)

0.002

Baseline parental emotional functioning*parent rater for ½ SD changea

  

1.7 (0.6)

0.003

Child age

-0.5 (0.2)

.008

-1.7 (0.8)

0.03

Log duration of illness

-1.2 (0.7)

.07

  

Transplant Type

    

 Autologous

4.2 (2.2)

.06

  

 Allogeneic, related

4.7 (2.0)

.02

  

 Allogeneic, unrelated (reference)

    

Early complicationsb

-1.8 (2.7)

.49

-2.0 (3.4)

0.57

Time*early complicationsb

    

 Baseline*early complications (reference)

    

 45 days*early complications

-6.4 (3.4)

.06

-10.1 (4.7)

0.03

 3 months*early complications

2.3 (3.6)

.52

-2.2 (4.9)

0.66

 6 months*early complications

4.1 (3.8)

.27

-3.3 (5.4)

0.54

 12 months*early complications

0.3 (6.2)

.96

-1.2 (6.3)

0.85

Late cGVHDc

7.6 (7.7)

.32

  

Time*Late cGVHDc

    

 Baseline*late cGVHD (reference)

    

 45 days* late cGVHD

-12.5 (9.3)

.18

  

 3 months* late cGVHD

-21.9 (9.7)

.02

  

 6 months* late cGVHD

-20.0 (9.4)

.03

  

 12 months* late cGVHD

-14.3 (10.5)

.17

  

Parent Female

  

-1.5 (4.0)

0.71

Parent Rater

  

-13.3 (4.6)

0.004

Parent female*Parent rater

  

-6.6 (3.2)

0.04

Time*Parent rater

    

 Baseline*parent rater (reference)

    

 45 days*parent rater

  

-4.5 (2.4)

0.054

 3 months*parent rater

  

-3.3 (2.4)

0.18

 6 months*parent rater

  

-1.5 (2.7)

0.57

 12 months*parent rater

  

1.1 (2.9)

0.71

  1. Abbreviations: SE standard error, SD standard deviation, cGVHD chronic graft versus host disease.
  2. a A half standard deviation for the parent emotional functioning is equal to 9.5.
  3. b Early complications refers to at least one of the following within the first 3 months: aGVHD of grade 2 or higher, intermediate or poor toxicity, or localized or systemic infection.
  4. c Late cGVHD refers to limited or extensive cGVHD between 6 and 12 months.