Longitudinal quality of life analysis in a phenylketonuria cohort provided sapropterin dihydrochloride

Table 3 Baseline age-adjusted correlations of PKU-QOL scores

	Impact	Worries	Satisfaction	Support	Generally	Total score
Age (years)	-.37*	-.35*	-.48**	NS	-.55**	-.58***
Age (years)	(−.63, -.04)	(−.61, -.02)	(−.70, -.17)	NS	(−.75, -.26)	(−.77, -.30)
Plasma Phe (μmoles/L)	NS	NS	NS	NS	NS	NS
Plasma Tyrosine (μmoles/L)	NS	-.39*	NS	NS	NS	NS
Plasma Tyrosine (μmoles/L)	NS	(.07, .64)	NS	NS	NS	NS
Phe tolerance (mg/day)	NS	NS	NS	NS	NS	NS
MF protein Rx (g/day)	NS	NS	NS	NS	NS	NS
Physical activity	NS	NS	NS	NS	.41*	NS
Physical activity	NS	NS	NS	NS	(.08, .66)	NS
Psych/Behavior diagnosis‡	NS	NS	-.38*	NS	NS	NS
			(−.63, -.05)

Pearson coefficient (95% CI).
*P < .05, **P < .01, ***P < .001.
CI = Confidence Interval, Rx = Prescription, MF = Medical food.
NS = Not statistically significant.
‡: Psychological and behavior diagnosis dummy coded in SPSS: 1 = no diagnosis, 2 = ADHD diagnosis, 3 = psychiatric diagnosis (Bipolar, Depression, Anxiety).

ISSN: 1477-7525