Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQL™ 4.0 Generic Core Scales: a study on behalf of the pays de Loire pediatric hematology network

Strullu, Marion; Rakotonjanahary, Josué; Tarral, Eliane; Savagner, Christophe; Thomas, Caroline; Méchinaud, Françoise; Reguerre, Yves; Poignant, Sylvaine; Boutet, Arnaud; Bassil, Joachim; Médinger, Dominique; Quemener, Emmanuel; Young, Nancy L; Rachieru, Petronela; Klaassen, Robert J; Pellier, Isabelle

doi:10.1186/1477-7525-11-193

Table 5 Factors associated with Minimal Clinically Important Difference (MCID) between health related quality of life scores at diagnosis and scores at month 6

From: Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQL™ 4.0 Generic Core Scales: a study on behalf of the pays de Loire pediatric hematology network

	Global score			Physical summary score			Psychosocial summary score			Emotional functioning			Social functioning			School functioning
	β	SE	p	β	SE	p	β	SE	p	β	SE	p	β	SE	p	β	SE	p
Gender
Female	0.32	0.54	0.55	0.28	0.54	0.59	−0.06	0.54	0.90	−0.01	0.53	0.97	−0.02	0.59	0.73	−0.54	0.57	0.34
Male	Ref			Ref			Ref			Ref			Ref			Ref
Age
2 - 4 years	0.51	0.63	0.41	0.44	0.59	0.45	1.05	0.71	0.14	0.65	0.59	0.27	−0.24	0.60	0.68	0.92	0.68	0.17
5 - 7 years	−0.02	0.72	0.96	1.28	1.08	0.23	0.74	0.97	0.45	1.28	1.08	0.23	1.08	1.03	0.29	−0.03	1.02	0.97
8 - 12 years	−0.35	0.58	0.54	0.13	0.41	0.75	−0.47	0.45	0.29	0.10	0.40	0.80	−0.34	0.44	0.44	−0.05	0.46	0.99
13 - 18 years	−0.69	0.57	0.22	−0.24	0.49	0.61	−0.44	0.51	0.38	0.66	0.58	0.25	−0.37	0.54	0.49	−1.52	0.83	0.06
Age < =10 years	0.77	0.57	0.18	−0.22	0.54	0.68	−0.28	0.55	0.60	−0.55	0.54	0.30	0.20	0.60	0.73	0.01	0.57	0.98
Preceding viral infection	1.25	0.57	0.03	0.48	0.58	0.4	0.78	0.61	0.20	−0.18	0.56	0.74	−0.96	0.61	0.11	0.82	0.65	0.20
ICIS scores
Score I	Ref			Ref			Ref			Ref			Ref			Ref
Score II	−15.2	109	0.98	14.5	198	0.99	14.4	208	0.99	14.8	203	0.99	15.4	331	0.99	13.52	167	0.99
Score III or IV	−14.9	109	0.98	14.6	198	0.99	14.9	208	0.99	15.01	203	0.99	15.25	331	0.99	14.39	167	0.99
Initial place of treatment
Inpatient	0.15	0.87	0.86	−0.87	0.74	0.23	−0.39	0.74	0.59	0.53	0.77	0.48	−1.45	0.77	0.05	1.49	1.11	0.17
Observation unit	0.22	1.05	0.83	−1.32	1.05	0.21	−0.87	1.05	0.40	0.18	1.01	0.85	−1.83	1.28	0.15	1.16	1.35	0.38
Outpatient	Ref			Ref			Ref			Ref			Ref			Ref
Initial treatment
Corticosteroid	0.81	0.60	0.17	−0.02	0,59	0.96	0.77	0.63	0.22	0.13	0.58	0.81	−0.02	0.66	0.96	1.21	0.72	0.09
IVIG	0.60	0.89	0.49	0.33	0.89	0.71	0.81	0.92	0.37	0.11	0.88	0.89	1.02	0.96	0.28	1.67	1.03	0.10
No treatment	Ref			Ref			Ref			Ref			Ref			Ref
Platelets
Platelets >100000 at month 6	0.67	0.57	0.23	0.12	0.56	0.82	0.20	0.57	0.71	−0.19	0.56	0.72	0.21	0.62	0.73	0.65	0.59	0.27

ref = reference/β coefficients and SEs from logistic regression such that positive β coefficient means that predictor or increasing values of predictor are associated with better quality of life with MCID.

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ISSN: 1477-7525

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