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Table 2 CML treatment restrictions, negative medication experiences, and overall disease burden, according to current CML treatment

From: Chronic myeloid leukemia (CML): association of treatment satisfaction, negative medication experience and treatment restrictions with health outcomes, from the patient’s perspective

  Imatinib Dasatinib Nilotinib Imatinib vs. Dasatinib Imatinib vs. Nilotinib Dasatinib vs. Nilotinib
  (N=208) (N=38) (N=49)    
  N % N % N % p-value p-value p-value
Treatment Restrictions          
Dietary Restrictions          
 While fasting 5 2.40% 0 0.00% 42 85.71% 0.33 <.01 <.01
 With food 146 70.19% 14 36.84% 2 4.08% <.01 <.01 <.01
 Without certain foods 88 42.31% 16 42.11% 36 73.47% 0.98 <.01 <.01
 With water 131 62.98% 15 39.47% 32 65.31% <.01 0.76 0.02
 Dissolve tablets in water and drink immediately 3 1.44% 0 0.00% 1 2.04% 0.46 0.76 0.38
 Without other non-CML medications 22 10.58% 2 5.26% 9 18.37% 0.31 0.13 0.07
Dosing Requirements          
 Once each day 105 50.48% 17 44.74% 3 6.12% 0.52 <.01 <.01
 Twice each day 15 7.21% 5 13.16% 32 65.31% 0.22 <.01 <.01
 Two or more pills at one time 26 12.50% 3 7.89% 24 48.98% 0.42 <.01 <.01
 At specific times of the day 101 48.56% 19 50.00% 31 63.27% 0.87 0.06 0.22
 At specific hours apart 32 15.38% 7 18.42% 38 77.55% 0.64 <.01 <.01
  Mean SD Mean SD Mean SD p-value p-value p-value
Treatment Restriction Score −0.06 0.69 −0.31 0.77 0.61 0.68 0.06 <.01 <.01
No. Treatment Doses (times per day) 1.20 0.50 1.32 0.62 1.88 0.39 0.27 <.01 <.01
Negative Medication Experience          
 Experienced Score 0.06 0.90 −0.10 0.98 0.07 0.91 0.35 0.96 0.42
 Bothersome Score 0.02 0.70 0.10 0.62 0.07 0.74 0.47 0.66 0.83
 Impact Score 0.02 0.66 0.10 0.57 0.11 0.65 0.45 0.38 0.93
No. Non-CML Medications per day 2.02 2.67 2.47 4.07 2.27 2.77 0.52 0.58 0.79
Time since CML diagnosis (years) 4.85 4.31 5.32 4.47 3.69 4.14 0.55 0.09 0.09
Time on Current CML Treatment (years) 4.60 2.98 2.07 1.69 1.55 1.35 <.01 <.01 0.12
No. Comorbidities 1.17 2.13 1.97 3.19 1.59 2.71 0.14 0.32 0.56
  1. Note: CML=Chronic Myeloid Leukemia, No.=Number of, SD=Standard Deviation.