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Table 3 PRO instruments identified in trials with NNRTIs

From: Patient reported outcome instruments used in clinical trials of HIV-infected adults on NNRTI-based therapy: a 10-year review

Instrument type and name Study count
Instruments measuring quality of life  
  SF-36 (v2) 2
  SF-12 (v2) 2
  EORTC QLQ-30 1
  Illness Intrusiveness Rating Scale (IIRS) 2
  Istituto Superiore di Sanità Quality of Life (ISSQoL) 1
  Medical Outcomes Study HIV (MOS-HIV) 81
  Functional Assessment of HIV Infection (FAHI) 3
  World Health Organization Quality of Life (WHOQOL)-HIV BREF 1
Instruments measuring symptoms  
General HIV symptoms  
  HIV Symptom Index (HIV-SI) /AIDS Clinical Trials Group Symptom Distress Module (SDM) 32
  Pittsburgh Sleep Quality Index (PSQI) 2
  Epworth Sleep Score (ESS) 2
  Stanford Sleepiness Scale (SSS) 2
  Groningen Sleep Quality Score (GSQS) 2
  Oviedo Sleep Questionnaire (OSQ) 1
Anxiety (only)  
  Hamilton Anxiety Rating Scale (HAM-A) 1
  State-Trait Anxiety Inventory for Adults (STAI) 1
Depression (only)  
  Centers for Epidemiological Studies-Depression (CES-D) 3
  Beck Depression Inventory-2nd edition (BDI-II) 1
  Hamilton Depression Rating Scale (HAM-D) 1
Anxiety and depression (only)  
  Hospital Anxiety and Depression Scale (HADS) 1
Anxiety, depression, and stress  
  Depression Anxiety and Stress Scale-short version (DASS21) 1
Psychiatric symptoms  
  Positive and Negative Syndrome Scale (PANSS) 1
  Positive and Negative Suicide Ideation (PANSI) 1
  Symptom Checklist-90 (SCL-90) - Somatization Subscale 1
  Body Image Impact scale 1
Instruments measuring beliefs about medications  
  Beliefs about Medicines Questionnaire-ART version (BMQ-ART) 2
  HAART Intrusiveness Scale 2
  1. 12 additional studies used modified versions of the MOS-HIV; 22 additional studies used the ACTG Adherence Questionnaire, which contains the HIV-SI/SDM.