Skip to main content

Table 3 Responsiveness of MusiQoL and SF-36 in the 417 non-worsened patients

From: Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study

  Baseline Month 6     Month 12     Month 18     Month 24    
MusiQoL M (SD) M (SD) D M6-BL ES p W/NW M (SD) D M12-BL ES p W/NW M (SD) D M18-BL ES p W/NW M (SD) D M24-BL ES p W/NW
ADL 62.8 (24.7) 64.7 (25.7) 1.97** 0.08 0.065 65.2 (24.6) 2.61*** 0.11 0.109 65.0 (26.1) 2.09*** 0.08 0.035 63.4 (26.4) 0.91 0.04 0.017
PWB 62.3 (23.8) 63.7 (24.7) 1.63 0.07 0.187 65.8 (23.7) 3.63*** 0.15 0.410 65.6 (25.2) 3.21*** 0.13 0.029 66.9 (25.0) 4.76*** 0.20 0.145
SPT 69.4 (22.3) 70.2 (22.3) 0.83 0.04 0.196 71.2 (21.0) 1.58 0.07 0.140 71.1 (23.0) 1.70 0.08 0.694 69.8 (23.2) 1.45 0.01 0.441
RFr 59.1 (29.0) 58.1 (27.8) −0.19 −0.01 0.601 58.6 (28.5) −0.19 −0.01 0.937 58.1 (28.1) −0.74 −0.03 0.301 58.8 (27.9) −0.20 −0.01 0.754
RFa 72.5 (27.7) 71.5 (28.2) −0.33 −0.01 0.136 69.9 (28.6) −2.26 −0.08 0.362 69.6 (28.8) −2.97* −0.11 0.792 70.0 (29.7) −2.29 −0.08 0.803
SSL 63.6 (29.7) 62.9 (29.9) −0.39 −0.01 0.383 62.4 (30.7) −1.12 −0.04 0.237 62.4 (30.3) −1.91 −0.06 0.010 63.2 (30.6) −0.03 −0.00 0.043
COP 62.1 (29.6) 64.8 (28.7) 3.12** 0.10 0.149 65.3 (29.1) 3.49** 0.12 0.370 65.6 (28.7) 3.65** 0.12 0.879 65.5 (28.2) 3.20* 0.11 0.467
REJ 82.6 (23.9) 84.2 (23.5) 1.88* 0.08 0.242 84.2 (22.8) 1.68 0.07 0.172 81.9 (24.4) −0.76 −0.03 0.749 82.3 (23.4) −0.22 −0.01 0.715
RHCS 85.2 (19.4) 84.7 (19.9) −0.60 −0.03 0.138 83.5 (20.6) −1.71 −0.09 0.517 83.5 (19.6) −2.13* −0.11 0.603 83.0 (18.8) −2.18* −0.11 0.219
Index 68.5 (14.8) 69.3 (15.0) 0.90 0.06 0.160 69.4 (15.4) 0.75 0.05 0.365 69.1 (16.4) 0.27 0.02 0.014 69.4 (15.6) 0.34 0.02 0.068
SF-36v2 M (SD) M (SD) D M6-BL ES p W/NW M (SD) D M12-BL ES p W/NW M (SD) D M18-BL ES p W/NW M (SD) D M24-BL ES p W/NW
PF 65.2 (27.7) 65.5 (27.4) 0.11 0.00 0.472 65.9 (28.0) 0.83 0.03 0.086 66.8 (29.0) 1.11 0.04 <10-3 65.4 (29.5) 0.30 0.01 <10-3
RP 60.2 (29.6) 62.0 (28.5) 1.63 0.06 0.733 63.1 (28.7) 3.08* 0.10 0.233 63.2 (28.8) 2.77* 0.09 0.016 63.1 (28.6) 3.06* 0.10 0.001
BP 66.8 (27.2) 66.9 (27.6) 0.08 0.00 0.628 67.5 (25.5) 0.36 0.01 0.866 68.2 (26.7) 1.12 0.04 0.139 67.0 (26.5) 0.28 0.01 0.044
GH 54.7 (22.4) 54.6 (22.4) −0.02 −0.01 0.766 54.9 (22.0) 0.10 0.00 0.107 53.1 (23.0) −1.35 −0.06 0.646 52.7 (23.7) −2.03* −0.09 0.859
Vi 48.8 (22.3) 49.3 (23.0) 0.72 0.03 0.667 50.0 (22.4) 1.22 0.05 0.779 50.4 (22.8) 1.54 0.07 0.681 48.7 (23.2) 0.09 0.00 0.965
SF 69.0 (26.6) 71.0 (27.0) 2.12 0.08 0.330 70.4 (27.2) 1.29 0.05 0.531 70.6 (26.2) 1.71 0.06 0.356 70.3 (26.3) 1.33 0.05 0.117
RE 56.1 (13.7) 56.0 (12.7) −0.08 −0.00 0.392 56.5 (12.0) 0.27 0.02 0.251 56.2 (11.5) −0.06 −0.00 0.466 56.2 (12.3) 0.04 0.00 0.124
MH 63.9 (20.5) 64.4 (21.3) 0.65 0.03 0.853 65.3 (19.5) 1.25 0.06 0.383 64.2 (20.6) 0.29 0.01 0.132 64.4 (20.7) 0.41 0.02 0.069
PCS 44.1 (10.0) 44.2 (10.1) 0.11 0.01 0.702 44.4 (10.1) 0.41 0.04 0.349 44.6 (10.5) 0.54 0.05 0.003 44.1 (10.5) 0.05 0.01 <10-3
MCS 43.8 (8.9) 44.2 (9.0) 0.38 0.04 0.260 44.3 (8.8) 0.48 0.05 0.773 44.0 (9.0) 0.04 0.00 0.973 44.0 (9.2) 0.20 0.02 0.700
  1. MusiQoL Multiple Sclerosis Quality of Life questionnaire.
  2. ADL activity of daily living, PWB psychological well-being, SPT symptoms, RFr relationships with friends, RFa relationships with family, SSL sentimental and sexual life, COP coping, REJ rejection, RHCS relationships with health care system.
  3. SF-36v2 Short Form 36 version 2.
  4. PF physical functioning, RP role physical, BP bodily pain, GH general health, Vi vitality, SF social functioning, RE role-emotional, MH mental health, PCS physical component summary, MCS mental component summary;
  5. M (SD), mean (standard deviation).
  6. DMi-BL: difference mean between the score of the evaluation time and the baseline score (a positive difference indicates a QoL improvement and a negative difference indicates a QoL deterioration), *p < =0.05, **p < =0.01, ***p < =0.001.
  7. ES, effect size; bold values indicate effect sizes > = 0.20.
  8. pW/NW, p-value of the comparison of standardized variation (final value minus the initial value divided by the initial value) between worsened and non-worsened individuals; italic values indicate p-value <0.05.