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Table 3 Responsiveness of MusiQoL and SF-36 in the 417 non-worsened patients

From: Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study

 

Baseline

Month 6

   

Month 12

   

Month 18

   

Month 24

   

MusiQoL

M (SD)

M (SD)

D M6-BL

ES

p W/NW

M (SD)

D M12-BL

ES

p W/NW

M (SD)

D M18-BL

ES

p W/NW

M (SD)

D M24-BL

ES

p W/NW

ADL

62.8 (24.7)

64.7 (25.7)

1.97**

0.08

0.065

65.2 (24.6)

2.61***

0.11

0.109

65.0 (26.1)

2.09***

0.08

0.035

63.4 (26.4)

0.91

0.04

0.017

PWB

62.3 (23.8)

63.7 (24.7)

1.63

0.07

0.187

65.8 (23.7)

3.63***

0.15

0.410

65.6 (25.2)

3.21***

0.13

0.029

66.9 (25.0)

4.76***

0.20

0.145

SPT

69.4 (22.3)

70.2 (22.3)

0.83

0.04

0.196

71.2 (21.0)

1.58

0.07

0.140

71.1 (23.0)

1.70

0.08

0.694

69.8 (23.2)

1.45

0.01

0.441

RFr

59.1 (29.0)

58.1 (27.8)

−0.19

−0.01

0.601

58.6 (28.5)

−0.19

−0.01

0.937

58.1 (28.1)

−0.74

−0.03

0.301

58.8 (27.9)

−0.20

−0.01

0.754

RFa

72.5 (27.7)

71.5 (28.2)

−0.33

−0.01

0.136

69.9 (28.6)

−2.26

−0.08

0.362

69.6 (28.8)

−2.97*

−0.11

0.792

70.0 (29.7)

−2.29

−0.08

0.803

SSL

63.6 (29.7)

62.9 (29.9)

−0.39

−0.01

0.383

62.4 (30.7)

−1.12

−0.04

0.237

62.4 (30.3)

−1.91

−0.06

0.010

63.2 (30.6)

−0.03

−0.00

0.043

COP

62.1 (29.6)

64.8 (28.7)

3.12**

0.10

0.149

65.3 (29.1)

3.49**

0.12

0.370

65.6 (28.7)

3.65**

0.12

0.879

65.5 (28.2)

3.20*

0.11

0.467

REJ

82.6 (23.9)

84.2 (23.5)

1.88*

0.08

0.242

84.2 (22.8)

1.68

0.07

0.172

81.9 (24.4)

−0.76

−0.03

0.749

82.3 (23.4)

−0.22

−0.01

0.715

RHCS

85.2 (19.4)

84.7 (19.9)

−0.60

−0.03

0.138

83.5 (20.6)

−1.71

−0.09

0.517

83.5 (19.6)

−2.13*

−0.11

0.603

83.0 (18.8)

−2.18*

−0.11

0.219

Index

68.5 (14.8)

69.3 (15.0)

0.90

0.06

0.160

69.4 (15.4)

0.75

0.05

0.365

69.1 (16.4)

0.27

0.02

0.014

69.4 (15.6)

0.34

0.02

0.068

SF-36v2

M (SD)

M (SD)

D M6-BL

ES

p W/NW

M (SD)

D M12-BL

ES

p W/NW

M (SD)

D M18-BL

ES

p W/NW

M (SD)

D M24-BL

ES

p W/NW

PF

65.2 (27.7)

65.5 (27.4)

0.11

0.00

0.472

65.9 (28.0)

0.83

0.03

0.086

66.8 (29.0)

1.11

0.04

<10-3

65.4 (29.5)

0.30

0.01

<10-3

RP

60.2 (29.6)

62.0 (28.5)

1.63

0.06

0.733

63.1 (28.7)

3.08*

0.10

0.233

63.2 (28.8)

2.77*

0.09

0.016

63.1 (28.6)

3.06*

0.10

0.001

BP

66.8 (27.2)

66.9 (27.6)

0.08

0.00

0.628

67.5 (25.5)

0.36

0.01

0.866

68.2 (26.7)

1.12

0.04

0.139

67.0 (26.5)

0.28

0.01

0.044

GH

54.7 (22.4)

54.6 (22.4)

−0.02

−0.01

0.766

54.9 (22.0)

0.10

0.00

0.107

53.1 (23.0)

−1.35

−0.06

0.646

52.7 (23.7)

−2.03*

−0.09

0.859

Vi

48.8 (22.3)

49.3 (23.0)

0.72

0.03

0.667

50.0 (22.4)

1.22

0.05

0.779

50.4 (22.8)

1.54

0.07

0.681

48.7 (23.2)

0.09

0.00

0.965

SF

69.0 (26.6)

71.0 (27.0)

2.12

0.08

0.330

70.4 (27.2)

1.29

0.05

0.531

70.6 (26.2)

1.71

0.06

0.356

70.3 (26.3)

1.33

0.05

0.117

RE

56.1 (13.7)

56.0 (12.7)

−0.08

−0.00

0.392

56.5 (12.0)

0.27

0.02

0.251

56.2 (11.5)

−0.06

−0.00

0.466

56.2 (12.3)

0.04

0.00

0.124

MH

63.9 (20.5)

64.4 (21.3)

0.65

0.03

0.853

65.3 (19.5)

1.25

0.06

0.383

64.2 (20.6)

0.29

0.01

0.132

64.4 (20.7)

0.41

0.02

0.069

PCS

44.1 (10.0)

44.2 (10.1)

0.11

0.01

0.702

44.4 (10.1)

0.41

0.04

0.349

44.6 (10.5)

0.54

0.05

0.003

44.1 (10.5)

0.05

0.01

<10-3

MCS

43.8 (8.9)

44.2 (9.0)

0.38

0.04

0.260

44.3 (8.8)

0.48

0.05

0.773

44.0 (9.0)

0.04

0.00

0.973

44.0 (9.2)

0.20

0.02

0.700

  1. MusiQoL Multiple Sclerosis Quality of Life questionnaire.
  2. ADL activity of daily living, PWB psychological well-being, SPT symptoms, RFr relationships with friends, RFa relationships with family, SSL sentimental and sexual life, COP coping, REJ rejection, RHCS relationships with health care system.
  3. SF-36v2 Short Form 36 version 2.
  4. PF physical functioning, RP role physical, BP bodily pain, GH general health, Vi vitality, SF social functioning, RE role-emotional, MH mental health, PCS physical component summary, MCS mental component summary;
  5. M (SD), mean (standard deviation).
  6. DMi-BL: difference mean between the score of the evaluation time and the baseline score (a positive difference indicates a QoL improvement and a negative difference indicates a QoL deterioration), *p < =0.05, **p < =0.01, ***p < =0.001.
  7. ES, effect size; bold values indicate effect sizes > = 0.20.
  8. pW/NW, p-value of the comparison of standardized variation (final value minus the initial value divided by the initial value) between worsened and non-worsened individuals; italic values indicate p-value <0.05.
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Health and Quality of Life Outcomes

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