Table 1 Methodological problems of Quality of Life (QOL) evaluation in the elderly
• Higher proportion of illiteracy as compared to younger patients |
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• Presence of cognitive disorders with difficulty to understand QOL questionnaires |
• Presence of comorbidities potentially confusing the real impact of cancer and treatment on QOL |
• Use of QOL instruments needs validation in elderly patients |
• Analysis of QOL data from subgroups of elderly patients enrolled in clinical trials without upper age limit suffer from selection bias. |