Self-reported health-related quality of life in persons with HIV infection: results from a multi-site interview project

Table 3 Adjusted health-related quality of life measures, stratified by CD4 count (N = 3772)

Disability Measure	CD4 <200 (n = 1950) (reference)		CD4 200–499 (n = 812)		CD4 ≥ 500 (n = 259)		CD4 Unknown (n = 751)
	mean	95% CL	mean	95% CL	mean	95% CL	mean	95% CL
Overall Health	45.5	42.7–48.2	56.8^a	53.7–59.9	64.7^b,c	60.3–69.0	49.4	46.2–52.7
Pain	61.8	58.6–65.0	67.6	64.0–71.2	71.6^c	66.6–76.6	64.8	61.0–68.5
Physical Functioning	56.6	53.4–59.7	70.7^a	67.2–74.2	78.1^c	73.2–83.1	67.0	63.3–70.7
Role Functioning	41.3	37.0–45.6	61.9^a	57.0–66.7	74.9^b,c	68.0–81.7	58.3	53.2–63.4
Social Functioning	61.8	58.7–64.9	75.3^a	71.8–78.8	84.3^b,c	79.4–89.1	70.5	66.9–74.2
Mental Health	57.1	54.8–59.3	59.1	56.5–61.6	61.1	57.5–64.6	58.7	56.0–61.3
Energy/Fatigue	45.4	43.0–47.7	53.3^a	50.6–55.9	58.8^c	55.0–62.5	49.8	47.0–52.6
Cognitive Functioning	71.0	68.6–73.4	74.2	71.5–76.9	76.4	72.7–80.2	78.0	75.2–80.8

least-squares means analysis; Tukey-Kramer adjustment for multiple comparisons; significance level P<0.05;
^* includes 318 persons who never had a CD4 test
^a significant pairwise difference: CD4 < 200 vs. CD4 200–499;
^b significant pairwise difference: CD4 200–499 vs. CD4 ≥ 500;
^c significant pairwise difference: CD4 < 200 vs. CD4 ≥ 500;
CL= confidence limit
factors in model: age, education, sex, race/ethnicity, HIV risk, health insurance status, income time known HIV+, current antiretroviral status, type of recruitment

ISSN: 1477-7525