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Table 5 Observed and adjusted changes of the QLQ–BR23 questionnaire after three and six months

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

 

After 3 months

After 6 months

 

Between T0 and T1

Between T1 and T2

QLQ-BR23

 

Observed changes

Adjusted changes

 

Observed changes

Adjusted changes

(post-test - pre-test)

(post-test - then-test)

(post-test - pre-test)

(post-test - then-test)

 

N

Mean (SD)

95% CI

Mean (SD)

95% CI

N

Mean (SD)

95% CI

Mean (SD)

95% CI

Body image

232

    

232

    

 Little worse

70

−20.44 (27.41)

(−26, −15)

−15.40 (25.02)

(−20, −10)

47

0.41 (16.58)

(−4, 4)

−10.76 (22.82)

(−16, −5)

 No change

41

−7.32 (15.16)

(−11, −3)

−4.07 (15.60)

(−8, 0)

46

2.72 (10.1)

(0, 5)

−0.91 (12.82)

(−4, 2)

 Little better

49

−14.91 (24.41)

(−21, −9)

−4.93 (18.31)

(−9, −1)

65

1.28 (22.93)

(−3, 6)

−1.45 (20.88)

(−6, 3)

Sexual functioning

198

    

198

    

 Little worse

56

6.85 (20.79)

(2, 11)

7.44 (21.06)

(3, 12)

56

−0.44 (12.55)

(−4, 3)

10.53 (17.93)

(6, 15)

 No change

34

3.92 (22.87)

(−3, 11)

5.88 (22.80)

(−1, 13)

34

2.03 (16.33)

(−2, 6)

2.44 (16.48)

(−2, 7)

 Little better

43

1.94 (15.94)

(−2, 6)

0 (10.91)

(−3, 3)

43

−0.89 (18.1)

(−5, 3)

0 (17.70)

(−4, 4)

Sexual enjoyment

74

    

74

    

 Little worse

23

14.49 (19.66)

(7, 22)

11.59 (19.09)

(5, 18)

23

12.50 (29.5)

(0, 25)

14.58 (20.97)

(5, 24)

 No change

16

10.42 (33.82)

(−4, 25)

4.17 (29.50)

(−9, 17)

16

1.45 (21.27)

(−6, 9)

2.90 (28.27)

(−7, 13)

 Little better

11

12.12 (22.47)

(0, 24)

9.09 (21.56)

(−3, 21)

11

−2.08 (22.67)

(−12, 8)

0 (21.08)

(−9, 9)

Future perspectives

236

    

236

    

 Little worse

68

7.35 (32.5)

(1, 14)

−8.82 (30.81)

(−15, −3)

68

3.47 (30.16)

(−4, 11)

−0.69 (24.30)

(−7, 5)

 No change

43

20.93 (32.55)

(13, 29)

7.75 (26.06)

(1, 14)

43

0 (23.57)

(−6, 6)

4.76 (30.43)

(−3, 12)

 Little better

48

10.42 (30.1)

(3, 18)

3.47 (24.06)

(−2, 9)

48

1.06 (25.38)

(−4, 6)

8.47 (23.92)

(3, 13)

Systemic therapy side effects

252

    

252

    

 Little worse

72

18.83 (21.51)

(15, 23)

19.79 (18.60)

(16, 23)

72

−3.49 (18.26)

(−8, 1)

10.27 (18.90)

(6, 15)

 No change

45

4.41 (15.02)

(1, 8)

3.84 (14.03)

(0, 7)

45

0.23 (10.2)

(−2, 3)

2.45 (7.89)

(1, 4)

 Little better

54

6.02 (13.64)

(3, 9)

6.02 (12.35)

(3, 9)

54

−4.19 (15.12)

(−7, −1)

3.94 (19.39)

(0, 8)

Breast symptoms

212

    

212

    

 Little worse

57

14.08 (27.69)

(8, 2)

18.08 (22.21)

(13, 23)

57

−4.31 (16.81)

(−8, 0)

6.44 (18.26)

(2, 11)

 No change

36

10.34 (20.43)

(5, 16)

9.72 (21.59)

(4, 16)

36

−3.57 (13.35)

(−7, 0)

3.77 (14.28)

(0, 7)

 Little better

53

16.61 (21.1)

(12, 21)

7.13 (18.87)

(3, 11)

53

−2.21 (20.17)

(−7, 2)

3.63 (20.65)

(−1, 8)

Arm symptoms

235

    

235

    

 Little worse

67

7.88 (17.6)

(4, 11)

8.54 (19.28)

(5, 12)

67

0.58 (18.27)

(−4, 5)

10.76 (19.53)

(6, 15)

 No change

41

3.39 (13.54)

(0, 7)

4.74 (14.14)

(1, 8)

41

1.89 (13.82)

(−1, 5)

5.89 (14.65)

(2, 9)

 Little better

55

4.55 (17.51)

(1, 8)

1.41 (13.83)

(−2, 5)

55

0.69 (13.98)

(−2, 4)

0.69 (16.93)

(−3, 4)

  1. Observed changes Post-test – Pre-test; adjusted changes: Post-test – Then-test
  2. SD standard deviation, CI confidence interval
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Health and Quality of Life Outcomes

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