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Table 5 Methodological quality assessment

From: Associations between psychological factors and health-related quality of life and global quality of life in patients with ALS: a systematic review

Reference

Year

Internal validity

Control of drop out

External validity

Statistical validity

Proportion

Sample size vs determinants

Multi-collinearity

Confounding bias

Reporting

Total (max 8 points)

Bremer [16]

2004

1

1

1

1

0

0

0

1

5.0

Chio [13]

2004

1

0.5

1

1

0

0

1

1

5.5

Clarke [15]

2001

1

1

1

1

0

0

0

1

5.0

Dal-Bello-Haas [47]

2000

1

0

0.5

1

0

0

0

1

3.5

Ganzini [45]

1999

0

1

0.5

1

1

0

1

1

5.5

Gibbons [37]

2013

1

0

1

1

1

1

1

1

7.0

Goldstein [38]

2002

1

0

1

1

0

0

0

0

3.0

Ilse [10]

2015

1

0

1

1

0

0

0

1

4.0

Krampe [27]

2008

0

0

1

1

0

0

1

1

4.0

Lule [28]

2008

1

0

0.5

1

0

0

1

1

4.5

Matuz [36]

2010

1

0

1

1

0

1

1

1

6.0

Matuz [30]

2015

1

1

1

1

0

0

1

1

6.0

McCabe [19]

2009

1

0

0.5

1

1

0

1

1

5.5

Montel [46]

2012

1

0

1

1

0

0

0

1

4.0

Pagnini [29]

2015

1

0.5

0.5

1

1

0

1

1

6.5

Peric [40]

2010

1

0.5

1

1

0

1

1

1

6.5

Pizzimenti [43]

2013

1

1

1

1

1

1

1

1

8.0

Robbins [31]

2001

1

0.5

0.5

1

1

0

1

1

6.0

Simmons [14]

2000

1

0.5

1

1

0

0

0

1

4.5

Tramtoni [42]

2012

1

0

0.5

1

0

0

1

1

4.5

Vignola [41]

2008

1

0.5

1

1

0

0

1

1

5.5

Winter [44]

2010

1

0.5

0.5

1

0

0

1

1

5.0

  1. Note. 1 = internal validity: use of validated and reliable measures, 2 = control of patient drop-out: including nonresponse analysis and describing executive patients, 3 = external validity: specifying in/exclusion criteria and demographic and disease characteristics (diagnosis, age, gender, site of ALS onset, time since diagnosis, severity), 4 = statistical validity: testing for statistical significance, 5 = adequate sample size in relation to the number of determinants (univariate ratio 20:1 and multivariate ratio 10:1), 6 = control for multicollinearity, 7 = control for potential confounding variables, 8 = clear description of main finding [17]