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Table 3 Assessment of coverage of HAE symptoms by the HAE PRO

From: Development and content validity testing of a patient-reported outcomes questionnaire for the assessment of hereditary angioedema in observational studies

Symptoms assessed by HAE PRO and mentioned by patients

Additional symptoms mentioned by patients (n = 43)

Abdominal pain (n = 30)

Stomach/bowel swelling (n = 13)

Skin swelling (n = 28)

Spasms/cramping (n = 8)

Vomiting (n = 15)

Tiredness (n = 8)

Nausea (n = 11)

Stomach ache (n = 6)

Diarrhoea (n = 13)

Difficulty breathing (n = 5)

Skin pain (n = 11)

Sore skin (n = 4)

Erythema (skin redness) (n = 8)

Constipation (n = 3)

Skin irritation (n = 5)

Tingling (n = 3)

Voice change (n = 4)

Tight skin (n = 3)

Difficulty swallowing (n = 3)

Red rings (n = 2)

 

Itching (n = 2)

 

Burning (n = 2)

 

Discomfort (n = 2)

 

Passing out/drop in blood pressure (n = 2)

 

Tight esophagus (n = 2)

 

Throat pain (n = 2)