Table 1 National Cancer Institute common terminology criteria for grading selected dermatologic adverse events*
Grade | Dry Skin | Nail changes | Pruritus/Itching | Rash/Desquamation | Rash: Acne/Acneiform |
|---|---|---|---|---|---|
1 | Asymptomatic | Discoloration, ridging, pitting | Mild or localized | Macular or papular eruption, or erythema without associated symptoms | Intervention not indicated |
2 | Symptomatic, not interfering with activities of daily living (AOL) | Partial or complete loss of nail(s); pain in nails | Intense or widespread | Macular or papular eruption, or erythema with pruritus or other associated symptoms; localized desquamation or other lesions covering < 50% body surface area (BSA) | Intervention indicated |
3 | Interfering with ADL | Interfering with ADL | Intense or widespread and interfering with ADL | Severe, generalized erythroderma, or macular, papular or vesicular eruption; desquamation covering > 50% BSA | Associated with pain, disfigurement, ulceration, or desquamation |
4 | - | - | - | Generalized, exfoliative, ulcerative, or bullous dermatitis | - |
5 | - | - | - | Death | Death |