Development of the Adult PedsQL™ Neurofibromatosis Type 1 Module: Initial Feasibility, Reliability and Validity

Table 3 Comparison of mean subscale scores among 3 groups of NF1 participants based on self-reported health status

Subscale	Excellent - Very good		Good		Fair - Poor		p-value*	Effect size
	N	Mean ± SD	N	Mean ± SD	N	Mean ± SD
Physical Functioning	46	79.66 ± 24.79	46	64.51 ± 25.99	41	43.29 ± 23.61	<.0001	.51
Emotional Functioning^#	47	60.64 ± 21.86	46	52.17 ± 26.32	41	40.37 ± 23.25	.001	.33
Social Functioning^#	47	72.34 ± 26.57	46	59.78 ± 28.86	41	49.09 ± 21.17	<.0001	.35
Cognitive Functioning^#	47	58.40 ± 26.66	46	54.02 ± 24.35	41	43.75 ± 22.25	.020	.24
Communication^#	46	74.28 ± 26.11	43	65.50 ± 26.39	38	57.24 ± 27.75	.016	.25
Worry	46	51.38 ± 24.77	43	44.77 ± 24.65	38	29.71 ± 19.79	<.0001	.36
Perceived Physical Appearance^#	46	46.92 ± 34.26	42	39.48 ± 35.69	38	28.73 ± 27.31	.044	.22
Pain and Hurt	46	74.09 ± 28.45	43	58.53 ± 25.10	38	23.25 ± 22.77	<.0001	.63
Paresthesias	46	73.10 ± 30.61	43	65.41 ± 25.71	38	34.21 ± 23.19	<.0001	.53
Skin Irritation	46	77.83 ± 20.46	43	65.23 ± 22.47	38	50.53 ± 25.14	<.0001	.44
Sensation^#	45	74.03 ± 21.48	42	67.26 ± 22.51	37	58.61 ± 26.82	.015	.26
Movement and Balance	46	87.91 ± 20.04	42	74.26 ± 21.08	37	51.69 ± 30.29	<.0001	.53
Daily Activities	46	95.61 ± 15.45	42	94.49 ± 16.13	36	75.46 ± 22.91	<.0001	.45
Fatigue	46	63.04 ± 27.81	42	58.93 ± 24.72	36	28.94 ± 19.05	<.0001	.52
Treatment Anxiety	46	82.79 ± 23.33	42	77.78 ± 23.47	36	62.50 ± 27.78	.001	.32
Total Score	47	74.37 ± 14.03	46	64.63 ± 15.64	41	48.37 ± 13.60	<.0001	.59

* p-values based on one-way ANOVA. Higher values equal better health-related quality of life. Effect sizes are designated as small (0.20), medium (0.50) and large (0.80). SD, standard deviation. ^# Except for these, Fair-Poor health status group was different from other two groups with p < .05 by Bonferroni test.

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