The Anti-Clot Treatment Scale (ACTS) in clinical trials: cross-cultural validation in venous thromboembolism patients

Table 3 ACTS Burdens and Benefits scales - EINSTEIN DVT dataset (all countries): data quality, scaling assumptions, targeting, reliability (N=1336)

	Data quality	Scaling assumptions					Targeting		Reliability
	Item missing data (%)^a	Possible range (midpoint)	Actual score range	Mean score	SD	CITC	Floor/ceiling effects (%)^b	Skewness	Cronbach’s alpha	Test-retest^c	Mean IIC^d	Range IIC
Burden items
Q1 Bleeding/vigorous activities	1	1–5	1–5	4.26	1.03	0.50	3/57	−1.41	-	-	-	-
Q2 Bleeding/usual activities	1	1–5	1–5	4.47	0.86	0.50	1/65	−1.79	-	-	-	-
Q3 Bruising	0	1–5	1–5	4.39	0.87	0.45	1/58	−1.49	-	-	-	-
Q4 Avoid other medicines	0	1–5	1–5	4.54	0.80	0.39	1/69	−1.84	-	-	-	-
Q5 Limit eat/drink	0	1–5	1–5	4.55	0.78	0.46	1/69	−1.87	-	-	-	-
Q6 Hassle/daily	0	1–5	1–5	4.41	0.78	0.60	0/56	−1.22	-	-	-	-
Q7 Hassle/occasional	1	1–5	1–5	4.02	0.98	0.57	2/38	−0.85	-	-	-	-
Q8 Difficult to follow your ACT	0	1–5	1–5	4.71	0.58	0.52	0/77	−2.19	-	-	-	-
Q9 Time-consuming ACT	0	1–5	1–5	4.52	0.69	0.43	0/62	−1.40	-	-	-	-
Q10 Worry about ACT	1	1–5	1–5	4.07	0.91	0.56	1/37	−0.84	-	-	-	-
Q11 Frustrating ACT	0	1–5	1–5	4.45	0.87	0.61	1/64	−1.76	-	-	-	-
Q12 Burden of ACT	1	1–5	1–5	4.49	0.75	0.65	0/62	−1.52	-	-	-	-
ACTS Burdens scale	4	12–60 (36)	23–60	52.9	6.1	-	0/11	−1.08	0.85	0.97	0.32	0.13–0.66
Benefit items
Q14 Confident in ACT	1	1–5	1–5	3.77	0.91	0.71	3/19	−0.88	-	-	-	-
Q15 Reassured by ACT	1	1–5	1–5	3.71	0.87	0.80	3/15	−0.84	-	-	-	-
Q16 Satisfied with ACT	0	1–5	1–5	3.79	0.90	0.69	3/19	−0.92	-	-	-	-
ACTS Benefits scale	1	3–15 (9)	3–15	11.3	2.4	-	1/10	−0.80	0.86	0.86	0.67	0.59–0.73

^aLess than 0.5% missing data rounded to 0. ^bCalculated as the percentage of people scoring either 12 (floor) or 60 (ceiling) on the ACTS Burdens scale or 3 (floor) or 15 (ceiling) on the ACTS Benefits scale. ^cTest-retest between two administrations at 12 weeks. ^dRepresenting homogeneity.
ACT anticoagulation treatment, ACTS Anti-Clot Treatment Scale, CITC corrected item-total correlation, IIC item-item correlation, SD standard deviation, - analyses not conducted owing to lack of data.

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