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  1. Patient-reported outcome (PROs) measures are being used more frequently in investigational studies of treatments for moderate to severe plaque psoriasis. The objective of this study was to examine the relation...

    Authors: Richard Shikiar, Mary Kaye Willian, Martin M Okun, Christine S Thompson and Dennis A Revicki

    Citation: Health and Quality of Life Outcomes 2006 4:71

    Content type: Research

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  2. Patient reported outcomes provide the patient's perspective on the effectiveness of treatment. The draft Food and Drug Administration guidance on patient reported outcomes for labeling and promotional claims r...

    Authors: Dennis A Revicki, David Cella, Ron D Hays, Jeff A Sloan, William R Lenderking and Neil K Aaronson

    Citation: Health and Quality of Life Outcomes 2006 4:70

    Content type: Commentary

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  3. The evaluation and use of patient reported outcome (PRO) measures requires detailed understanding of the meaning of the outcome of interest. The Food and Drug Administration (FDA) recently presented its draft ...

    Authors: Jan L Brożek, Gordon H Guyatt and Holger J Schünemann

    Citation: Health and Quality of Life Outcomes 2006 4:69

    Content type: Commentary

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  4. Our objective was to test a brief, symptom index for advanced renal cell carcinoma, a disease affecting over 38,000 Americans each year and often diagnosed in late stages.

    Authors: David T Eton, David Cella, Jennifer Bacik and Robert J Motzer

    Citation: Health and Quality of Life Outcomes 2006 4:68

    Content type: Research

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  5. The purpose of this review was to: (1) locate all exercise treatment studies of fibromyalgia (FM) patients from 1988 through 2005, (2) present in tabular format the key details of each study and (3) to provide...

    Authors: Kim Dupree Jones, Dianne Adams, Kerri Winters-Stone and Carol S Burckhardt

    Citation: Health and Quality of Life Outcomes 2006 4:67

    Content type: Review

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  6. Measuring health-related quality of life (HRQOL) is important in arthritis and the SF-36v2 is the current state-of-the-art. It is only emerging how well the Centers for Disease Control and Prevention (CDC) HRQ...

    Authors: Thelma Mielenz, Elizabeth Jackson, Shannon Currey, Robert DeVellis and Leigh F Callahan

    Citation: Health and Quality of Life Outcomes 2006 4:66

    Content type: Research

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  7. A recently published article by the Scientific Advisory Committee of the Medical Outcomes Trust presents guidelines for selecting and evaluating health status and health-related quality of life measures used i...

    Authors: Mark J Atkinson and Richard D Lennox

    Citation: Health and Quality of Life Outcomes 2006 4:65

    Content type: Commentary

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  8. This proof of concept (POC) study was designed to evaluate the use of an Internet-based bulletin board technology to aid parallel cross-cultural development of thematic content for a new set of patient-reporte...

    Authors: Mark J Atkinson, Jan Lohs, Ilka Kuhagen, Julie Kaufman and Shamsu Bhaidani

    Citation: Health and Quality of Life Outcomes 2006 4:64

    Content type: Research

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  9. Most studies on health-related quality of life (HRQOL) in children with cancer focussed on survivors. Only few studies have evaluated patients during ongoing oncological treatment. The aim of this study was a ...

    Authors: Markus A Landolt, Margarete Vollrath, Felix K Niggli, Hanspeter E Gnehm and Felix H Sennhauser

    Citation: Health and Quality of Life Outcomes 2006 4:63

    Content type: Research

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  10. This article deals with the problem of interpreting health-related quality of life (HRQL) outcomes in clinical trials. First, we will briefly describe how dichotomization and item response theory can facilitat...

    Authors: Holger J Schünemann, Elie A Akl and Gordon H Guyatt

    Citation: Health and Quality of Life Outcomes 2006 4:62

    Content type: Commentary

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  11. Health-Related Quality of Life (HRQOL) studies concerning children and adolescents are a growing field of research. The Pediatric Quality of Life Inventory (PedsQL™) is considered as a promising HRQOL instrume...

    Authors: Trude Reinfjell, Trond H Diseth, Marijke Veenstra and Arne Vikan

    Citation: Health and Quality of Life Outcomes 2006 4:61

    Content type: Research

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  12. We evaluated how well physicians' global estimates of disease severity correspond to more specific physician-rated disease variables as well as patients' self-rated health and other patient variables.

    Authors: Kurt Kroenke, Kathleen W Wyrwich, William M Tierney, Ajit N Babu and Fredric D Wolinsky

    Citation: Health and Quality of Life Outcomes 2006 4:60

    Content type: Research

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  13. The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbid...

    Authors: Samir K Ballas, Franca B Barton, Myron A Waclawiw, Paul Swerdlow, James R Eckman, Charles H Pegelow, Mabel Koshy, Bruce A Barton and Duane R Bonds

    Citation: Health and Quality of Life Outcomes 2006 4:59

    Content type: Research

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  14. In situations where children are unable or unwilling to respond for themselves, measurement of quality of life (QOL) is often obtained by parent proxy-report. However the relationship between child self and pa...

    Authors: Joanne Cremeens, Christine Eiser and Mark Blades

    Citation: Health and Quality of Life Outcomes 2006 4:58

    Content type: Research

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  15. Single item questions about self ratings of overall health status are widely used in both military and civilian surveys. Limited information is available to date that examines what relationships exist between ...

    Authors: Christopher K Haddock, Walker SC Poston, Sara A Pyle, Robert C Klesges, Mark W Vander Weg, Alan Peterson and Margaret Debon

    Citation: Health and Quality of Life Outcomes 2006 4:57

    Content type: Research

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  16. The objective was to study whether a Kiswahili version of the OIDP (Oral Impacts on Daily Performance) inventory was valid and reliable for use in a population of older adults in urban and rural areas of Tanza...

    Authors: IA Kida, AN Åstrøm, GV Strand, JR Masalu and G Tsakos

    Citation: Health and Quality of Life Outcomes 2006 4:56

    Content type: Research

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  17. To analyse the cross-diagnostic validity of the Functional Independence Measure (FIM™) motor items in patients with spinal cord injury, stroke and traumatic brain injury and the comparability of summed scores ...

    Authors: Å Lundgren-Nilsson, A Tennant, G Grimby and KS Sunnerhagen

    Citation: Health and Quality of Life Outcomes 2006 4:55

    Content type: Research

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  18. Changes in scores on health status questionnaires are difficult to interpret. Several methods to determine minimally important changes (MICs) have been proposed which can broadly be divided in distribution-bas...

    Authors: Henrica C de Vet, Caroline B Terwee, Raymond W Ostelo, Heleen Beckerman, Dirk L Knol and Lex M Bouter

    Citation: Health and Quality of Life Outcomes 2006 4:54

    Content type: Commentary

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  19. If the SF-36 summary scores are used as health status measures for the purpose of measuring health inequality it is relevant to be informed about the sources of the inequality in order to be able to target the...

    Authors: Jens Gundgaard and Jørgen Lauridsen

    Citation: Health and Quality of Life Outcomes 2006 4:53

    Content type: Research

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  20. We constructed a concise multidimensional care burden scale that reflects circumstances unique to Japan, with a focus on intractable neurological diseases. We surveyed 646 family caregivers of patients with in...

    Authors: Mitsunori Miyashita, Aki Yamaguchi, Mami Kayama, Yugo Narita, Norikazu Kawada, Miki Akiyama, Akiko Hagiwara, Yoshimi Suzukamo and Shunichi Fukuhara

    Citation: Health and Quality of Life Outcomes 2006 4:52

    Content type: Research

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  21. The Asthma Symptom Utility Index (ASUI) is a preference-based outcome measure used in US clinical trials and cost-effectiveness studies for asthma. This study evaluated ASUI preference weights in Europe to det...

    Authors: Emuella M Flood, Erwin De Cock, Ann-Christin Mörk and Dennis A Revicki

    Citation: Health and Quality of Life Outcomes 2006 4:51

    Content type: Research

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  22. This research was conducted to confirm the validity and reliability and to assess the responsiveness and clinical meaningfulness of the OnyCOE-t, a questionnaire specifically designed to measure patient-reported...

    Authors: Lori P Potter, Susan D Mathias, Monika Raut, Farid Kianifard and Amir Tavakkol

    Citation: Health and Quality of Life Outcomes 2006 4:50

    Content type: Research

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  23. Many studies have demonstrated that health related quality of life (HRQoL) improves, on average, after coronary artery bypass graft surgery (CABGS). However, this average improvement may not be realized for al...

    Authors: Michael R Le Grande, Peter C Elliott, Barbara M Murphy, Marian UC Worcester, Rosemary O Higgins, Christine S Ernest and Alan J Goble

    Citation: Health and Quality of Life Outcomes 2006 4:49

    Content type: Research

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  24. About 20% of schoolchildren and adolescents in Sweden suffer from perceived food hypersensitivity (e.g. allergy or intolerance). Our knowledge of how child food hypersensitivity affects parents HRQL and what a...

    Authors: Birgitta Marklund, Staffan Ahlstedt and Gun Nordström

    Citation: Health and Quality of Life Outcomes 2006 4:48

    Content type: Research

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  25. Information on health related quality of life (HR-QOL) can be integrated with other classical health status indicators and be used to assist policy makers in resource allocation decisions. For this reason inst...

    Authors: Elena Savoia, Maria Pia Fantini, Pier Paolo Pandolfi, Laura Dallolio and Natalina Collina

    Citation: Health and Quality of Life Outcomes 2006 4:47

    Content type: Research

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  26. Patient-reported quality of life is strongly affected by some dermatologic conditions. We developed a Japanese version of the Dermatology Life Quality Index (DLQI-J) and used psychometric methods to examine it...

    Authors: Natsuko Takahashi, Yoshimi Suzukamo, Motonobu Nakamura, Yoshiki Miyachi, Joseph Green, Yukihiro Ohya, Andrew Y Finlay and Shunichi Fukuhara

    Citation: Health and Quality of Life Outcomes 2006 4:46

    Content type: Research

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  27. The management of Barrett's esophagus (BE), particularly high grade dysplasia (HGD), is an area of much debate and controversy. Surgical esophagectomy, intensive endoscopic surveillance and mucosal ablative te...

    Authors: Chin Hur, Eve Wittenberg, Norman S Nishioka and G Scott Gazelle

    Citation: Health and Quality of Life Outcomes 2006 4:45

    Content type: Research

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  28. Cultural norms indicate that obesity reflects increased wealth and prosperity. Yet obesity is linked to serious medical illnesses. The purpose of this study was to determine if Ghanaian women would change thei...

    Authors: Rosemary B Duda, Naana Afua Jumah, Allan G Hill, Joseph Seffah and Richard Biritwum

    Citation: Health and Quality of Life Outcomes 2006 4:44

    Content type: Research

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  29. Despite a growing literature on the efficacy of behavioral weight loss interventions, we still know relatively little about the long terms effects they have on HRQL. Therefore, we conducted a study to investig...

    Authors: Bryan Blissmer, Deborah Riebe, Gabriela Dye, Laurie Ruggiero, Geoffrey Greene and Marjorie Caldwell

    Citation: Health and Quality of Life Outcomes 2006 4:43

    Content type: Research

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  30. The Osteoporosis Patient Satisfaction Questionnaire (OPSAT-Q) is a new measure of patient satisfaction with bisphosphonate treatment for osteoporosis. The objective of this study was to evaluate the psychometr...

    Authors: Emuella M Flood, Kathleen M Beusterien, Hannah Green, Richard Shikiar, Robert W Baran, Mayur M Amonkar and David Cella

    Citation: Health and Quality of Life Outcomes 2006 4:42

    Content type: Research

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  31. Telesurveillance is a technologically based modality that allows the surveillance of patients in the natural setting, mainly home. It is based on communication technologies to relay information between a patie...

    Authors: Claude Vincent, Daniel Reinharz, Isabelle Deaudelin, Mathieu Garceau and Lise R Talbot

    Citation: Health and Quality of Life Outcomes 2006 4:41

    Content type: Research

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  32. Health Related Quality of Life (HRQoL) studies on children with chronic illness such as thalassaemia are limited. We conducted the first study to investigate if children with thalassaemia have a lower quality ...

    Authors: Adriana Ismail, Michael J Campbell, Hishamshah Mohd Ibrahim and Georgina L Jones

    Citation: Health and Quality of Life Outcomes 2006 4:39

    Content type: Research

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  33. To evaluate the psychometric properties of the Child-OIDP for use among children in the UK and report on the prevalence of oral impacts in a sample of schoolchildren in Westminster.

    Authors: Huda Yusuf, Sudaduang Gherunpong, Aubrey Sheiham and Georgios Tsakos

    Citation: Health and Quality of Life Outcomes 2006 4:38

    Content type: Research

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  34. Physical activity is associated with health-related quality of life (HRQL) in clinical populations, but less is known whether this relationship exists in older men and women who are healthy. Thus, this study d...

    Authors: Luke S Acree, Jessica Longfors, Anette S Fjeldstad, Cecilie Fjeldstad, Bob Schank, Kevin J Nickel, Polly S Montgomery and Andrew W Gardner

    Citation: Health and Quality of Life Outcomes 2006 4:37

    Content type: Research

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  35. The aim of this study was to develop and conduct preliminary validation of the Perceived Impact of Problem Profile (PIPP). Based on the biopsychosocial model of health and functioning, the PIPP was intended as...

    Authors: Julie F Pallant, RoseAnne Misajon, Elizabeth Bennett and Lenore Manderson

    Citation: Health and Quality of Life Outcomes 2006 4:36

    Content type: Research

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  36. Psoriasis is one of the prevalent skin conditions in the United States. This chronic condition has a significant negative impact on patients' quality of life. Psoriasis has been linked to the depression and su...

    Authors: Monali J Bhosle, Amit Kulkarni, Steven R Feldman and Rajesh Balkrishnan

    Citation: Health and Quality of Life Outcomes 2006 4:35

    Content type: Review

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  37. Sociological and economic risk factors of visual impairment have never been described in France at a national level as the association between the number of ophthalmologists per inhabitant and visual impairmen...

    Authors: Antoine J Lafuma, Antoine P Brézin, Francis L Fagnani, Mounir Mesbah and Gilles H Berdeaux

    Citation: Health and Quality of Life Outcomes 2006 4:34

    Content type: Research

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  38. Modern psychometric methods based on item response theory (IRT) can be used to develop adaptive measures of health-related quality of life (HRQL). Adaptive assessment requires an item bank for each domain of H...

    Authors: Jacek A Kopec, Eric C Sayre, Aileen M Davis, Elizabeth M Badley, Michal Abrahamowicz, Lesley Sherlock, J Ivan Williams, Aslam H Anis and John M Esdaile

    Citation: Health and Quality of Life Outcomes 2006 4:33

    Content type: Research

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  39. The Menopause Rating Scale is a health-related Quality of Life scale developed in the early 1990s and step-by-step validated since then. Recently the MRS scale was validated as outcomes measure for hormone the...

    Authors: Jürgen Dinger, Thomas Zimmermann, Lothar AJ Heinemann and Diana Stoehr

    Citation: Health and Quality of Life Outcomes 2006 4:32

    Content type: Research

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  40. COPD is currently the fourth cause of morbidity and mortality in the developed world. Patients with COPD experience a progressive deterioration and disability, which lead to a worsening in their health-related...

    Authors: Pilar Carrasco Garrido, Javier de Miguel Díez, Javier Rejas Gutiérrez, Antonio Martín Centeno, Elena Gobartt Vázquez, Ángel Gil de Miguel, Marta García Carballo and Rodrigo Jiménez García

    Citation: Health and Quality of Life Outcomes 2006 4:31

    Content type: Research

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  41. In this paper, we report the health related quality of life (HRQOL) data from patients with hepatitis C viral infection (HCV) who were refractory to prior therapy and had re-treatment with a combination of Peg...

    Authors: Abraham Mathew, Laurie P Peiffer, Kathy Rhoades and Thomas J McGarrity

    Citation: Health and Quality of Life Outcomes 2006 4:30

    Content type: Research

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  42. An increasing awareness of the need to address sexual and orgasm experiences as part of life quality and an understanding of the great individual differences between women play roles in women's health and medi...

    Authors: Ansa Ojanlatva, Juha Mäkinen, Hans Helenius, Katariina Korkeila, Jari Sundell and Päivi Rautava

    Citation: Health and Quality of Life Outcomes 2006 4:29

    Content type: Research

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  43. Treating anemia associated with chemotherapy and many cancers is often necessary. However, patient satisfaction with anemia treatment is limited by the lack of validated instruments. We developed and validated...

    Authors: Robert J Nordyke, Chih-Hung Chang, Chiun-Fang Chiou, Joel F Wallace, Bin Yao and Lee S Schwartzberg

    Citation: Health and Quality of Life Outcomes 2006 4:28

    Content type: Research

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  44. Little is known about longitudinal associations among measures of depression, mental and physical health, and quality of life (QOL). We followed 982 clinically depressed persons to determine which measures cha...

    Authors: Paula H Diehr, Ann M Derleth, Stephen P McKenna, Mona L Martin, Donald M Bushnell, Gregory Simon and Donald L Patrick

    Citation: Health and Quality of Life Outcomes 2006 4:27

    Content type: Research

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  45. Attention-Deficit/Hyperactivity Disorder (ADHD) is the most common chronic mental health condition in children and adolescents. The application of health-related quality of life (HRQOL) as a pediatric population ...

    Authors: James W Varni and Tasha M Burwinkle

    Citation: Health and Quality of Life Outcomes 2006 4:26

    Content type: Research

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  46. Assessment of Health Related Quality of Life (HRQL) has become increasingly important and various direct and indirect methods and instruments have been devised to measure it. In direct methods such as Visual A...

    Authors: Amir Adel Rashidi, Aslam H Anis and Carlo A Marra

    Citation: Health and Quality of Life Outcomes 2006 4:25

    Content type: Research

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  47. Patients with moderate to severe malignancy-related pain frequently require the use of opioid pharmacotherapy. Unfortunately, many cancer patients continue to be prescribed subtherapeutic doses of pain medicat...

    Authors: Tracy L Skaer

    Citation: Health and Quality of Life Outcomes 2006 4:24

    Content type: Review

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