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Table 4 Regression models for HSUVs

From: The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression

Variables

Estimated coefficient ± 95% CI

Age-adjusted

No age adjustment

Coefficient (95% CI)

p value

Coefficient (95% CI)

p value

Age

-0.001 (-0.004, 0.002)

0.502

-

-

Health state reference: stable state (n = 32)

 Progressed state (n = 10)

-0.052 (-0.097, -0.007)

0.027

-0.055 (-0.102, -0.008)

0.021

 Advanced state (n = 8)

-0.143 (-0.264, -0.022)

0.02

-0.146 (-0.267, -0.024)

0.055

Instrument reference: EQ-5D-3L instrument (n = 43)

 EQ-5D-5L (n = 7)

0.176 (0.115, 0.237)

 < 0.001

0.176 (0.120, 0.233)

0.025

Treatment reference: surgery alone (n = 3)

 Surgery adjuvant chemotherapy (n = 20)

0.205 (0.133, 0.277)

 < 0.001

0.209 (0.144, 0.274)

0.029

 Surgery adjuvant radiotherapy (n = 2)

0.200 (0.141, 0.259)

 < 0.001

0.204 (0.157, 0.252)

0.021

 Surgery adjuvant endocrine therapy (n = 5)

0.085 (0.036, 0.135)

0.003

0.085 (0.040, 0.131)

0.020

 Surgery without specified adjuvant (n = 19)

0.107 (0.069, 0.144)

 < 0.001

0.114 (0.084, 0.144)

0.013

 Unspecified treatment (n = 1)

0.148 (0.081, 0.215)

<0.001

0.136 (0.072, 0.200)

0.029

Valuation time reference: less than one year (n = 19)

 Over 1 year (n = 31)

0.045 (0.006, 0.083)

0.027

0.050 (0.012, 0.088)

0.017

 Constant

0.696 (0.485, 0.908)

 < 0.001

0.639 (0.575, 0.703)

 0.029

 Observations

50

50

 R-squared

0.691

0.686