Improving multimorbidity measurement using individualized disease-specific quality of life impact assessments: predictive validity of a new comorbidity index

McEntee, Mindy L.; Gandek, Barbara; Ware, John E.

doi:10.1186/s12955-022-02016-7

Table 4 Estimates of unique effects of chronic conditions on MCS and PCS used in MCC weighting, developmental sample (N = 5490)

From: Improving multimorbidity measurement using individualized disease-specific quality of life impact assessments: predictive validity of a new comorbidity index

Chronic condition^a	N	MCS			PCS
Chronic condition^a	N	b	SE	t	b	SE	t
Hypertension	3185	−0.27	0.25	−1.05	−1.40	0.26	−5.40***
Myocardial infarction	123	−0.76	0.77	−0.99	−2.43	0.78	−3.10**
Angina	433	0.05	0.44	0.11	−1.36	0.45	−3.04**
CHF	477	−1.24	0.42	−2.96***	−3.67	0.43	−8.59***
Diabetes	2231	−0.64	0.26	−2.45*	−1.17	0.27	−4.40***
Stroke	285	−0.95	0.53	−1.77	−2.59	0.54	−4.78***
Cancer	629	−0.95	0.37	−2.60***	−0.60	0.37	−1.63
Asthma	1700	−0.77	0.28	−2.80**	−0.51	0.28	−1.80
COPD	634	−0.94	0.37	−2.52*	−4.27	0.38	11.36***
CKD	387	−0.14	0.46	−0.31	−1.82	0.46	−3.94***
RA	909	−0.97	0.32	−3.00**	−4.35	0.33	−13.26***
OA	2107	−0.24	0.28	−0.84	−4.90	0.29	−17.08***
Osteoporosis	623	−0.08	0.38	−0.20	−1.13	0.39	−2.93**
Ulcer	753	−0.99	0.35	−2.85**	−0.94	0.35	−2.67*
Liver disease	169	−0.78	0.67	−1.16	−0.88	0.68	−1.29
Irritable bowel syndrome	694	−1.57	0.36	−4.35***	−0.36	0.37	−0.98
Obesity	1900	−0.77	0.26	−2.93**	−1.76	0.26	−6.63***
HIV or AIDS	27	−0.17	1.63	−0.11	−0.10	1.65	−0.06
Anemia	897	−0.29	0.33	−0.91	−0.64	0.33	−1.95
Depression	1058	−7.82	0.31	−25.09***	−0.08	0.32	−0.26
Chronic fatigue syndrome	235	−3.55	0.61	−5.81***	−3.25	0.62	−5.25***
Fibromyalgia	390	−1.67	0.49	−3.40**	−3.43	0.50	−6.87***
Migraine headaches	1013	−0.58	0.31	−1.84	−0.63	0.32	−1.97*
Prostate disease	616	0.01	0.41	0.03	−0.47	0.42	−1.12
Erectile dysfunction	684	−0.87	0.40	−2.20*	−1.00	0.40	−2.48*
Hypothyroidism	919	0.18	0.32	0.57	0.00	0.32	−0.01
Allergies, chronic	1836	−0.24	0.27	−0.89	−0.10	0.27	−0.37
Allergies, seasonal	2739	0.19	0.24	0.76	0.92	0.25	3.70***
Chronic back problem	1840	−1.63	0.27	−6.17***	−4.15	0.27	−15.47***
Vision trouble	814	−2.64	0.33	−7.89***	−2.15	0.34	−6.33***
Hearing, trouble	1124	−0.43	0.30	−1.46	−0.80	0.30	−2.66***
Osteoporosis	812	−0.84	0.32	−2.59*	−0.92	0.33	−2.80**
Limited use arm/leg	697	−1.12	0.62	−1.82	−6.55	0.63	−10.42
Foot/ankle joint problem	1099	−1.74	0.55	−3.16**	−1.42	0.56	−2.54*
Hip/knee joint problem	2225	−0.15	0.42	−0.35	−2.49	0.42	−5.87***
Constant (Intercept)		51.93	0.44		53.46	0.40

MCS Short Form-8 Mental Component Score, PCS Short Form-8 Physical Component Score. ^aConditions common to 35-item and Charlson checklists are in italics. ***p < 0.001; **p < 0.01; *p < 0.05. Each regression model adjusted for main effects of age, gender, education, and race/ethnicity

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