Table 5 Hypotheses for PROMIS-29 construct validity

Physical function

SF-12 PF

SF-12 PCS

All other dissimilar constructs of legacy measures (n = 8)

Females will have lower physical function scores than males;

Patients ages > 65 will have lower physical function scores than patients ages < 50;

Patients with type A AD will have lower physical function scores than type B AD patients;

Patients with CCI ≥ 3 will have lower physical function scores than patients with CCI < 2

76%

Anxiety

GAD-2

SF-12 MCS

All other dissimilar constructs of legacy measures (n = 8)

Females will have higher anxiety scores than males;

Patients with type A AD will have higher anxiety scores than Type B AD patients

82%

Depression

PHQ-2

SF-12 MCS

All other dissimilar constructs of legacy measures (n = 8)

Females will have higher depression scores than males;

73%

Fatigue

SF-12 vitality

All other dissimilar constructs of legacy measures (n = 8)

Females will have higher fatigue scores than males;

82%

SSS-8 tiredness

Patients with CCI ≥ 3 will have higher fatigue scores than patients with CCI < 2

Sleep disturbance

SSS-8 sleep

All other dissimilar constructs of legacy measures (n = 9)

Females will have higher sleep disturbance scores than males

91%

Social roles

SF-12 SF

All other dissimilar constructs of legacy measures (n = 9)

Females will have lower social roles scores than males;

Patients ages > 65 will have lower social roles scores than patients ages < 50;

Patients with type A AD will have lower social roles scores than type B AD patients;

Patients with CCI ≥ 3 will have lower social roles scores than patients with CCI < 2

86%

Pain interference

SSS-8 pain

All other dissimilar constructs of legacy measures (n = 9)

Females will have higher pain interference scores than males

91%