|  |  | Baseline |  | Follow-up |  | ES | SRM | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | 95%-CI | Mean | 95%-CI | |||||||||||
SF-36 | Score | (mean, sd) | 51.7 | 23.3 | Â | 75.9 | 17.2 | Â | 1.04 | 0.83 | 1.24 | 1.20 | 0.96 | 1.43 |
Physical functioning | Norm | (mean, sd) | 68.9 | 22.5 | Â | 68.7 | 22.8 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.75 | − 1.09 | − 0.40 | 0.35 | 0.02 | 0.69 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 41.0 | 30.4 | Â | 65.7 | 25.6 | Â | 0.81 | 0.59 | 1.04 | 0.85 | 0.62 | 1.09 |
Role physical | Norm | (mean, sd) | 64.4 | 20.4 | Â | 64.2 | 20.9 | Â | Â | Â | Â | Â | Â | Â |
 | SMD |  | − 0.90 | − 1.25 | − 0.56 | 0.06 | − 0.27 | 0.39 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 59.6 | 29.3 | Â | 79.0 | 23.1 | Â | 0.66 | 0.47 | 0.86 | 0.80 | 0.57 | 1.04 |
Bodily pain | Norm | (mean, sd) | 52.3 | 12.3 | Â | 52.1 | 12.5 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | 0.32 | − 0.01 | 0.65 | 1.43 | 1.07 | 1.80 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 62.1 | 19.8 | Â | 72.8 | 17.1 | Â | 0.54 | 0.33 | 0.75 | 0.61 | 0.38 | 0.85 |
General health | Norm | (mean, sd) | 53.4 | 9.1 | Â | 53.4 | 9.1 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | 0.57 | 0.23 | 0.90 | 1.41 | 1.04 | 1.78 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 54.7 | 20.6 | Â | 70.5 | 18.9 | Â | 0.76 | 0.55 | 0.97 | 0.86 | 0.63 | 1.10 |
Vitality | Norm | (mean, sd) | 54.7 | 10.2 | Â | 54.6 | 10.2 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, sd) | 0.00 | − 0.33 | 0.33 | 1.04 | 0.69 | 1.39 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 71.8 | 29.5 | Â | 86.3 | 22.6 | Â | 0.49 | 0.28 | 0.71 | 0.55 | 0.31 | 0.78 |
Social functioning | Norm | (mean, sd) | 81.3 | 7.3 | Â | 81.2 | 7.3 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.44 | − 0.77 | − 0.11 | 0.30 | − 0.03 | 0.63 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 71.8 | 29.9 | Â | 81.7 | 23.3 | Â | 0.33 | 0.11 | 0.55 | 0.36 | 0.12 | 0.60 |
Role emotional | Norm | (mean, sd) | 81.9 | 9.1 | Â | 81.9 | 9.1 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.45 | − 0.79 | − 0.12 | − 0.01 | − 0.34 | 0.32 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 76.1 | 17.5 | Â | 83.2 | 16.7 | Â | 0.40 | 0.19 | 0.61 | 0.45 | 0.21 | 0.69 |
Mental health | Norm | (mean, sd) | 70.1 | 7.4 | Â | 70.0 | 7.4 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | 0.45 | 0.12 | 0.78 | 1.01 | 0.66 | 1.37 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 37.3 | 11.0 | Â | 47.3 | 7.5 | Â | 0.91 | 0.71 | 1.12 | 1.05 | 0.81 | 1.28 |
Physical CS | Norm | (mean, sd) | 40.4 | 7.6 | Â | 40.3 | 7.7 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.33 | − 0.66 | 0.01 | 0.91 | 0.57 | 1.26 |  |  |  |  |  |  |
SF-36 | Score | (mean, sd) | 50.9 | 12.3 | Â | 54.0 | 10.3 | Â | 0.25 | 0.07 | 0.44 | 0.32 | 0.08 | 0.56 |
Mental CS | Norm | (mean, sd) | 51.1 | 2.9 | Â | 51.1 | 2.9 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.02 | − 0.35 | 0.31 | 0.38 | 0.05 | 0.71 |  |  |  |  |  |  |
SCL-90R | Score | (mean, sd) | 87.7 | 14.9 | Â | 93.0 | 12.7 | Â | 0.35 | 0.23 | 0.47 | 0.68 | 0.44 | 0.92 |
Depression | Norm | (mean, sd) | 89.8 | 3.5 | Â | 89.8 | 3.5 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.20 | − 0.53 | 0.13 | 0.33 | 0.00 | 0.66 |  |  |  |  |  |  |
SCL-90R | Score | (mean, sd) | 92.8 | 9.6 | Â | 96.3 | 7.9 | Â | 0.36 | 0.19 | 0.54 | 0.49 | 0.26 | 0.73 |
Anxiety | Norm | (mean, sd) | 93.6 | 2.4 | Â | 93.6 | 2.4 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.12 | − 0.45 | 0.21 | 0.45 | 0.12 | 0.79 |  |  |  |  |  |  |
SCL-90R | Score | (mean, sd) | 95.0 | 8.2 | Â | 96.0 | 7.7 | Â | 0.12 | 0.00 | 0.25 | 0.23 | -0.01 | 0.47 |
Phobic anxiety | Norm | (mean, sd) | 96.8 | 1.2 | Â | 96.8 | 1.2 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.31 | − 0.64 | 0.02 | − 0.15 | − 0.48 | 0.18 |  |  |  |  |  |  |
SCL-90R | Score | (mean, sd) | 94.0 | 9.1 | Â | 96.1 | 7.0 | Â | 0.23 | 0.08 | 0.39 | 0.35 | 0.12 | 0.59 |
Interpersonal sensitivity | Norm | (mean, sd) | 91.1 | 2.2 | Â | 91.0 | 2.2 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | 0.44 | 0.11 | 0.78 | 0.98 | 0.63 | 1.32 |  |  |  |  |  |  |
SCL-90R | Score | (mean, sd) | 86.2 | 12.3 | Â | 91.8 | 8.2 | Â | 0.45 | 0.29 | 0.61 | 0.67 | 0.44 | 0.91 |
Somatization | Norm | (mean, sd) | 88.5 | 3.3 | Â | 88.5 | 3.3 | Â | Â | Â | Â | Â | Â | Â |
 | SMD | (mean, 95%-CI) | − 0.26 | − 0.59 | 0.07 | 0.51 | 0.18 | 0.85 |  |  |  |  |  |  |
CSQ Catastrophizing | Score | (mean, sd) | 83.6 | 16.8 | Â | 91.3 | 13.0 | Â | 0.46 | 0.26 | 0.65 | 0.56 | 0.32 | 0.79 |
CSQ Control pain | Score | (mean, sd) | 55.1 | 28.2 | Â | 68.2 | 30.2 | Â | 0.47 | 0.23 | 0.71 | 0.46 | 0.22 | 0.69 |
CSQ Decrease pain | Score | (mean, sd) | 54.4 | 26.8 | Â | 68.5 | 24.7 | Â | 0.53 | 0.27 | 0.78 | 0.48 | 0.24 | 0.72 |
6MWD | meters | (mean, sd) | 361.8 | 125.5 | Â | 479.8 | 118.5 | Â | 0.94 | 0.75 | 1.13 | 1.19 | 0.95 | 1.43 |