Development and content validation of patient-reported outcomes tools for ulcerative colitis and Crohn’s disease in adults with moderate-to-severe disease

Table 5 Symptoms reported by at least four participants in the CD study (N = 12)^a

Symptom^b	Total reported^c	Spontaneous report^d	Probed report^d
Abdominal pain^e	12 (100)	12 (100)	0 (0)
Diarrhea/loose stools^e	11 (92)	10 (91)	1 (9)
Urgent bowel movements^e	10 (83)	5 (50)	5 (50)
Fatigue/tiredness/weakness	7 (58)	7 (100)	0 (0)
Frequent bowel movements^e	7 (58)	6 (86)	1 (14)
Bloody stools^e	7 (58)	4 (57)	3 (43)
Nausea^e	6 (50)	1 (17)	5 (83)
Vomiting^e	5 (42)	2 (40)	3 (60)
Incontinence^e	4 (33)	0 (0)	4 (100)
Constipation	4 (33)	4 (100)	0 (0)
Joint aches/body aches	4 (33)	4 (100)	0 (0)

CD, Crohn’s disease; PRO, patient-reported outcomes
^aSymptoms reported by 1–3 participants: eye problems (n = 3), bloating/gas (n = 3), bruising (n = 2), difficulty eating certain foods (n = 2), general pain (n = 2), lack of appetite (n = 2), chest pain (n = 1), gastroesophageal reflux (n = 1), hemorrhoids (n = 1), and skin issues (n = 1)
^bParticipants reported on current and past symptoms experienced
^cData are number of participants (%); percentage calculated as a proportion of the overall group (N = 12)
^dData are number of participants (%); percentage calculated as a proportion of the ‘total reported’
^eItems in the PRO-CD Diary

ISSN: 1477-7525