Table 3 Description of economic evaluations included in the review
From: Health-related quality of life in individuals with genital herpes: a systematic review
Lead author | Evaluation aims | Year | Country | QALYs | Perspective | Population | Health States included for HSUVs | Sensitivity analysis | Source for HSUVs |
|---|---|---|---|---|---|---|---|---|---|
Baker [17] | Determine whether serologic testing for herpes simplex virus type 2 (HSV-2) in pregnant women and their partners is cost-effective | 2004 | USA | Yes | Societal | Pregnant women | Neonatal herpes infection (mild, moderate, severe, normal or no permanent impairment) | One-way and multiway | [22] |
Caviness [18] | Determine the clinical effectiveness and cost-effectiveness of testing for and empirically treating HSV infection in neonates with fever aged from birth to 28Â days | 2008 | USA | Yes | Societal | Febrile neonates | Neonatal herpes infection (normal, mild, moderate, severe, death) | One-way, probabilistic sensitivity analysis using Monte Carlo simulation | [22] |
Chatroux [4] | Estimate whether serotyping women with a history of genital HSV and an outbreak during the third trimester of pregnancy is cost-effective compared with no serotyping | 2021 | USA | Yes | Societal | Pregnant women | Neonatal HSV infection (mild, moderate, severe, death) From neonatal and maternal perspective | One-way, probabilistic sensitivity analysis using a Monte Carlo simulation | [22] |
Little [19] | Addresses whether it would be clinically beneficial and cost-effective to offer prophylactic acyclovir to women with a history of HSV but no recurrence during pregnancy | 2005 | USA | Yes | Health care | Pregnant women | Neonatal HSV infection (neonatal perspective: moderate disability, severe disability) (maternal perspective: caesarean delivery, having an impaired child, losing a child) | One-way, probabilistic sensitivity analysis using a Monte Carlo simulation | |
Smith [20] | Investigate the effect of including treatment of disease stigma on the cost-effectiveness of genital herpes treatment | 2000 | USA | Yes | Societal | Adults with genital herpes | Genital herpes | Multiple sensitivity analyses | Not stated |
Tuite [16] | Assess the effectiveness and cost-effectiveness of identifying pregnant women at risk of de novo HSV acquisition as a means of preventing vertical HSV transmission | 2011 | Canada | Yes | Unclear | Pregnant women | Neonatal HSV infection (normal/mild, moderate, severe, death) | One-way, multi-way, probabilistic sensitivity analysis | [26] |
Thung [21] | Determine the cost-effectiveness of routine antenatal screening for herpes simplex virus 1 and 2 in women without a known history of genital herpes | 2005 | USA | Yes | Health care | Pregnant women | Neonatal HSV infection (normal, mild, moderate, severe) | One-way | [27] |