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Table 3 Description of economic evaluations included in the review

From: Health-related quality of life in individuals with genital herpes: a systematic review

Lead author Evaluation aims Year Country QALYs Perspective Population Health States included for HSUVs Sensitivity analysis Source for HSUVs
Baker [17] Determine whether serologic testing for herpes simplex virus type 2 (HSV-2) in pregnant women and their partners is cost-effective 2004 USA Yes Societal Pregnant women Neonatal herpes infection (mild, moderate, severe, normal or no permanent impairment) One-way and multiway [22]
Caviness [18] Determine the clinical effectiveness and cost-effectiveness of testing for and empirically treating HSV infection in neonates with fever aged from birth to 28 days 2008 USA Yes Societal Febrile neonates Neonatal herpes infection (normal, mild, moderate, severe, death) One-way, probabilistic sensitivity analysis using Monte Carlo simulation [22]
Chatroux [4] Estimate whether serotyping women with a history of genital HSV and an outbreak during the third trimester of pregnancy is cost-effective compared with no serotyping 2021 USA Yes Societal Pregnant women Neonatal HSV infection (mild, moderate, severe, death)
From neonatal and maternal perspective
One-way, probabilistic sensitivity analysis using a Monte Carlo simulation [22]
Little [19] Addresses whether it would be clinically beneficial and cost-effective to offer prophylactic acyclovir to women with a history of HSV but no recurrence during pregnancy 2005 USA Yes Health care Pregnant women Neonatal HSV infection (neonatal perspective: moderate disability, severe disability) (maternal perspective: caesarean delivery, having an impaired child, losing a child) One-way, probabilistic sensitivity analysis using a Monte Carlo simulation [23,24,25]
Smith [20] Investigate the effect of including treatment of disease stigma on the cost-effectiveness of genital herpes treatment 2000 USA Yes Societal Adults with genital herpes Genital herpes Multiple sensitivity analyses Not stated
Tuite [16] Assess the effectiveness and cost-effectiveness of identifying pregnant women at risk of de novo HSV acquisition as a means of preventing vertical HSV transmission 2011 Canada Yes Unclear Pregnant women Neonatal HSV infection (normal/mild, moderate, severe, death) One-way, multi-way, probabilistic sensitivity analysis [26]
Thung [21] Determine the cost-effectiveness of routine antenatal screening for herpes simplex virus 1 and 2 in women without a known history of genital herpes 2005 USA Yes Health care Pregnant women Neonatal HSV infection (normal, mild, moderate, severe) One-way [27]
  1. HSUV health-state utility values; HSV Herpes simplex virus; QALY quality-adjusted life year